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Title: Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan

Abstract

Background: Cumulative arsenic exposure (CAE) from drinking water has been shown to be associated with hypertension in a dose-response pattern. This study further explored the association between arsenic methylation capability and hypertension risk among residents of arseniasis-hyperendemic areas in Taiwan considering the effect of CAE and other potential confounders. Method: There were 871 subjects (488 women and 383 men) and among them 372 were diagnosed as having hypertension based on a positive history or measured systolic blood pressure {>=} 140 mm Hg and/or diastolic blood pressure {>=} 90 mm Hg. Urinary arsenic species were determined by high-performance liquid chromatography-hydride generator and atomic absorption spectrometry. Primary arsenic methylation index [PMI, defined as monomethylarsonic acid (MMA{sup V}) divided by (As{sup III} + As{sup V})] and secondary arsenic methylation index (SMI, defined as dimethylarsinic acid divided by MMA{sup V}) were used as indicators for arsenic methylation capability. Results: The level of urinary arsenic was still significantly correlated with cumulative arsenic exposure (CAE) calculated from a questionnaire interview (p = 0.02) even after the residents stopped drinking the artesian well water for 2-3 decades. Hypertensive subjects had higher percentages of MMA{sup V} and lower SMI than subjects without hypertension. However, subjects having CAE >more » 0 mg/L-year had higher hypertension risk than those who had CAE = 0 mg/L-year disregard a high or low methylation index. Conclusion: Inefficient arsenic methylation ability may be related with hypertension risk.« less

Authors:
 [1];  [2];  [3];  [3];  [4];  [5];  [6];  [3];  [7]
  1. Graduate Institute of Medical Sciences, School of Medicine, Taipei Medical University, Taipei, Taiwan (China)
  2. National Taiwan University College of Medicine, Taipei, Taiwan (China)
  3. (China)
  4. Department of Public Health, School of Medicine, Taipei Medical University, No. 250 Wu-Hsing Street, Taipei 110, Taiwan (China)
  5. Department of Nuclear Science, National Tsing-Hua University, Hsinchu, Taiwan (China)
  6. Genomic Research Center, Academia Sinica, Taipei, Taiwan (China)
  7. Department of Public Health, School of Medicine, Taipei Medical University, No. 250 Wu-Hsing Street, Taipei 110, Taiwan (China). E-mail: ymhsueh@tmu.edu.tw
Publication Date:
OSTI Identifier:
20976847
Resource Type:
Journal Article
Resource Relation:
Journal Name: Toxicology and Applied Pharmacology; Journal Volume: 218; Journal Issue: 2; Other Information: DOI: 10.1016/j.taap.2006.10.022; PII: S0041-008X(06)00365-6; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ABSORPTION SPECTROSCOPY; ARSENIC; BIOLOGICAL INDICATORS; BLOOD PRESSURE; DRINKING WATER; HEALTH HAZARDS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HYDRIDES; HYPERTENSION; METHYLATION; MITES; TAIWAN

Citation Formats

Huang, Y.-K., Tseng, C.-H., Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Department of Medical Research and Development, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan, Huang, Y.-L., Yang, M.-H., Chen, C.-J., Graduate Institute of Epidemiology, College of Public Health, National Taiwan University Taipei, Taiwan, and Hsueh, Y.-M.. Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan. United States: N. p., 2007. Web. doi:10.1016/j.taap.2006.10.022.
Huang, Y.-K., Tseng, C.-H., Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Department of Medical Research and Development, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan, Huang, Y.-L., Yang, M.-H., Chen, C.-J., Graduate Institute of Epidemiology, College of Public Health, National Taiwan University Taipei, Taiwan, & Hsueh, Y.-M.. Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan. United States. doi:10.1016/j.taap.2006.10.022.
Huang, Y.-K., Tseng, C.-H., Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Department of Medical Research and Development, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan, Huang, Y.-L., Yang, M.-H., Chen, C.-J., Graduate Institute of Epidemiology, College of Public Health, National Taiwan University Taipei, Taiwan, and Hsueh, Y.-M.. Mon . "Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan". United States. doi:10.1016/j.taap.2006.10.022.
@article{osti_20976847,
title = {Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan},
author = {Huang, Y.-K. and Tseng, C.-H. and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan and Department of Medical Research and Development, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan and Huang, Y.-L. and Yang, M.-H. and Chen, C.-J. and Graduate Institute of Epidemiology, College of Public Health, National Taiwan University Taipei, Taiwan and Hsueh, Y.-M.},
abstractNote = {Background: Cumulative arsenic exposure (CAE) from drinking water has been shown to be associated with hypertension in a dose-response pattern. This study further explored the association between arsenic methylation capability and hypertension risk among residents of arseniasis-hyperendemic areas in Taiwan considering the effect of CAE and other potential confounders. Method: There were 871 subjects (488 women and 383 men) and among them 372 were diagnosed as having hypertension based on a positive history or measured systolic blood pressure {>=} 140 mm Hg and/or diastolic blood pressure {>=} 90 mm Hg. Urinary arsenic species were determined by high-performance liquid chromatography-hydride generator and atomic absorption spectrometry. Primary arsenic methylation index [PMI, defined as monomethylarsonic acid (MMA{sup V}) divided by (As{sup III} + As{sup V})] and secondary arsenic methylation index (SMI, defined as dimethylarsinic acid divided by MMA{sup V}) were used as indicators for arsenic methylation capability. Results: The level of urinary arsenic was still significantly correlated with cumulative arsenic exposure (CAE) calculated from a questionnaire interview (p = 0.02) even after the residents stopped drinking the artesian well water for 2-3 decades. Hypertensive subjects had higher percentages of MMA{sup V} and lower SMI than subjects without hypertension. However, subjects having CAE > 0 mg/L-year had higher hypertension risk than those who had CAE = 0 mg/L-year disregard a high or low methylation index. Conclusion: Inefficient arsenic methylation ability may be related with hypertension risk.},
doi = {10.1016/j.taap.2006.10.022},
journal = {Toxicology and Applied Pharmacology},
number = 2,
volume = 218,
place = {United States},
year = {Mon Jan 15 00:00:00 EST 2007},
month = {Mon Jan 15 00:00:00 EST 2007}
}