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Title: Total mercury levels in hair, toenail, and urine among women free from occupational exposure and their relations to renal tubular function

Abstract

To investigate the relations among total mercury levels in hair, toenail, and urine, together with potential effects of methylmercury intake on renal tubular function, we determined their levels, and urinary N-acetyl-{beta}-d-glucosaminidase activity (NAG) and {alpha}{sub 1}-microglobulin (AMG) in 59 women free from occupational exposures, and estimated daily mercury intakes from fish and other seafood using a food frequency questionnaire. Mercury levels (mean+/-SD) in the women were 1.51+/-0.91{mu}g/g in hair, 0.59+/-0.32{mu}g/g in toenail, and 0.86+/-0.66{mu}g/g creatinine in urine; and, there were positive correlations among them (P<0.001). The daily mercury intake of 9.15+/-7.84{mu}g/day was significantly correlated with total mercury levels in hair, toenail, and urine (r=0.551, 0.537, and 0.604, P<0.001). Among the women, the NAG and AMG were positively correlated with both the daily mercury intake and mercury levels in hair, toenail, and urine (P<0.01); and, these relations were almost similar when using multiple regression analysis to adjust for possible confounders such as urinary cadmium (0.47+/-0.28{mu}g/g creatinine) and smoking status. In conclusion, mercury resulting from fish consumption can explain total mercury levels in hair, toenail, and urine to some degree (about 30%), partly through the degradation into the inorganic form, and it may confound the renal tubular effect of other nephrotoxic agents.more » Also, the following equation may be applicable to the population neither with dental amalgam fillings nor with occupational exposures: [hair mercury ({mu}g/g)]=2.44x[toenail mercury ({mu}g/g)].« less

Authors:
 [1];  [2];  [1];  [1];  [1];  [3]
  1. Department of Environmental Health Sciences, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543 (Japan)
  2. Department of Epidemiology, National Institute for Minamata Disease, Minamata 867-0008 (Japan)
  3. Department of Environmental Health Sciences, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543 (Japan). E-mail: winestem@med.akita-u.ac.jp
Publication Date:
OSTI Identifier:
20972063
Resource Type:
Journal Article
Resource Relation:
Journal Name: Environmental Research; Journal Volume: 103; Journal Issue: 2; Other Information: DOI: 10.1016/j.envres.2006.06.009; PII: S0013-9351(06)00145-9; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; CADMIUM; CREATININE; HAIR; INTAKE; KIDNEYS; MERCURY; MERCURY ALLOYS; METHYLMERCURY; OCCUPATIONAL EXPOSURE; SEAFOOD; URINE; WOMEN

Citation Formats

Ohno, Tomoko, Sakamoto, Mineshi, Kurosawa, Tomoko, Dakeishi, Miwako, Iwata, Toyoto, and Murata, Katsuyuki. Total mercury levels in hair, toenail, and urine among women free from occupational exposure and their relations to renal tubular function. United States: N. p., 2007. Web. doi:10.1016/j.envres.2006.06.009.
Ohno, Tomoko, Sakamoto, Mineshi, Kurosawa, Tomoko, Dakeishi, Miwako, Iwata, Toyoto, & Murata, Katsuyuki. Total mercury levels in hair, toenail, and urine among women free from occupational exposure and their relations to renal tubular function. United States. doi:10.1016/j.envres.2006.06.009.
Ohno, Tomoko, Sakamoto, Mineshi, Kurosawa, Tomoko, Dakeishi, Miwako, Iwata, Toyoto, and Murata, Katsuyuki. Thu . "Total mercury levels in hair, toenail, and urine among women free from occupational exposure and their relations to renal tubular function". United States. doi:10.1016/j.envres.2006.06.009.
@article{osti_20972063,
title = {Total mercury levels in hair, toenail, and urine among women free from occupational exposure and their relations to renal tubular function},
author = {Ohno, Tomoko and Sakamoto, Mineshi and Kurosawa, Tomoko and Dakeishi, Miwako and Iwata, Toyoto and Murata, Katsuyuki},
abstractNote = {To investigate the relations among total mercury levels in hair, toenail, and urine, together with potential effects of methylmercury intake on renal tubular function, we determined their levels, and urinary N-acetyl-{beta}-d-glucosaminidase activity (NAG) and {alpha}{sub 1}-microglobulin (AMG) in 59 women free from occupational exposures, and estimated daily mercury intakes from fish and other seafood using a food frequency questionnaire. Mercury levels (mean+/-SD) in the women were 1.51+/-0.91{mu}g/g in hair, 0.59+/-0.32{mu}g/g in toenail, and 0.86+/-0.66{mu}g/g creatinine in urine; and, there were positive correlations among them (P<0.001). The daily mercury intake of 9.15+/-7.84{mu}g/day was significantly correlated with total mercury levels in hair, toenail, and urine (r=0.551, 0.537, and 0.604, P<0.001). Among the women, the NAG and AMG were positively correlated with both the daily mercury intake and mercury levels in hair, toenail, and urine (P<0.01); and, these relations were almost similar when using multiple regression analysis to adjust for possible confounders such as urinary cadmium (0.47+/-0.28{mu}g/g creatinine) and smoking status. In conclusion, mercury resulting from fish consumption can explain total mercury levels in hair, toenail, and urine to some degree (about 30%), partly through the degradation into the inorganic form, and it may confound the renal tubular effect of other nephrotoxic agents. Also, the following equation may be applicable to the population neither with dental amalgam fillings nor with occupational exposures: [hair mercury ({mu}g/g)]=2.44x[toenail mercury ({mu}g/g)].},
doi = {10.1016/j.envres.2006.06.009},
journal = {Environmental Research},
number = 2,
volume = 103,
place = {United States},
year = {Thu Feb 15 00:00:00 EST 2007},
month = {Thu Feb 15 00:00:00 EST 2007}
}