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Title: Kilo-Voltage Cone-Beam Computed Tomography Setup Measurements for Lung Cancer Patients; First Clinical Results and Comparison With Electronic Portal-Imaging Device

Abstract

Purpose: Kilovoltage cone-beam computed tomography (CBCT) has been developed to provide accurate soft-tissue and bony setup information. We evaluated clinical CBCT setup data and compared CBCT measurements with electronic portal imaging device (EPID) images for lung cancer patients. Methods and Materials: The setup error for CBCT scans at the treatment unit relative to the planning CT was measured for 62 patients (524 scans). For 19 of these patients (172 scans) portal images were also made. The mean, systematic setup error ({sigma}), and random setup error ({sigma}) were calculated for the CBCT and the EPID. The differences between CBCT and EPID and the rotational setup error derived from the CBCT were also evaluated. An offline shrinking action level correction protocol, based on the CBCT measurements, was used to reduce systematic setup errors and the impact of this protocol was evaluated. Results: The CBCT setup errors were significantly larger than the EPID setup errors for the cranial-caudal and anterior-posterior directions (p < 0.05). The mean overall setup errors after correction measured with the CBCT were 0.2 mm ({sigma} = 1.6 mm, {sigma} 2.9 mm) in the left-right, -0.8 mm ({sigma} = 1.7 mm, {sigma} = 4.0 mm) in cranial-caudal and 0.0 mmmore » ({sigma} = 1.5 mm, {sigma} = 2.0 mm) in the anterior-posterior direction. Using our correction protocol only 2 patients had mean setup errors larger than 5 mm, without this correction protocol 51% of the patients would have had a setup error larger than 5 mm. Conclusion: Use of CBCT scans provided more accurate information concerning the setup of lung cancer patients than did portal imaging.« less

Authors:
 [1];  [1];  [1];  [1];  [1];  [2]
  1. Department of Radiation Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)
  2. Department of Radiation Oncology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands). E-mail: j.lebesque@nki.nl
Publication Date:
OSTI Identifier:
20951678
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 68; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2007.01.014; PII: S0360-3016(07)00129-0; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BEAMS; CARCINOMAS; COMPARATIVE EVALUATIONS; COMPUTERIZED TOMOGRAPHY; CORRECTIONS; ELECTRIC POTENTIAL; EQUIPMENT; ERRORS; IMAGES; LUNGS; PATIENTS; RADIOTHERAPY

Citation Formats

Borst, Gerben R., Sonke, Jan-Jakob, Betgen, Anja, Remeijer, Peter, Herk, Marcel van, and Lebesque, Joos V.. Kilo-Voltage Cone-Beam Computed Tomography Setup Measurements for Lung Cancer Patients; First Clinical Results and Comparison With Electronic Portal-Imaging Device. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2007.01.014.
Borst, Gerben R., Sonke, Jan-Jakob, Betgen, Anja, Remeijer, Peter, Herk, Marcel van, & Lebesque, Joos V.. Kilo-Voltage Cone-Beam Computed Tomography Setup Measurements for Lung Cancer Patients; First Clinical Results and Comparison With Electronic Portal-Imaging Device. United States. doi:10.1016/j.ijrobp.2007.01.014.
Borst, Gerben R., Sonke, Jan-Jakob, Betgen, Anja, Remeijer, Peter, Herk, Marcel van, and Lebesque, Joos V.. Fri . "Kilo-Voltage Cone-Beam Computed Tomography Setup Measurements for Lung Cancer Patients; First Clinical Results and Comparison With Electronic Portal-Imaging Device". United States. doi:10.1016/j.ijrobp.2007.01.014.
@article{osti_20951678,
title = {Kilo-Voltage Cone-Beam Computed Tomography Setup Measurements for Lung Cancer Patients; First Clinical Results and Comparison With Electronic Portal-Imaging Device},
author = {Borst, Gerben R. and Sonke, Jan-Jakob and Betgen, Anja and Remeijer, Peter and Herk, Marcel van and Lebesque, Joos V.},
abstractNote = {Purpose: Kilovoltage cone-beam computed tomography (CBCT) has been developed to provide accurate soft-tissue and bony setup information. We evaluated clinical CBCT setup data and compared CBCT measurements with electronic portal imaging device (EPID) images for lung cancer patients. Methods and Materials: The setup error for CBCT scans at the treatment unit relative to the planning CT was measured for 62 patients (524 scans). For 19 of these patients (172 scans) portal images were also made. The mean, systematic setup error ({sigma}), and random setup error ({sigma}) were calculated for the CBCT and the EPID. The differences between CBCT and EPID and the rotational setup error derived from the CBCT were also evaluated. An offline shrinking action level correction protocol, based on the CBCT measurements, was used to reduce systematic setup errors and the impact of this protocol was evaluated. Results: The CBCT setup errors were significantly larger than the EPID setup errors for the cranial-caudal and anterior-posterior directions (p < 0.05). The mean overall setup errors after correction measured with the CBCT were 0.2 mm ({sigma} = 1.6 mm, {sigma} 2.9 mm) in the left-right, -0.8 mm ({sigma} = 1.7 mm, {sigma} = 4.0 mm) in cranial-caudal and 0.0 mm ({sigma} = 1.5 mm, {sigma} = 2.0 mm) in the anterior-posterior direction. Using our correction protocol only 2 patients had mean setup errors larger than 5 mm, without this correction protocol 51% of the patients would have had a setup error larger than 5 mm. Conclusion: Use of CBCT scans provided more accurate information concerning the setup of lung cancer patients than did portal imaging.},
doi = {10.1016/j.ijrobp.2007.01.014},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 2,
volume = 68,
place = {United States},
year = {Fri Jun 01 00:00:00 EDT 2007},
month = {Fri Jun 01 00:00:00 EDT 2007}
}