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Title: Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging in Patients With Carcinoma of the Nasopharynx: Diagnostic Accuracy and Impact on Clinical Management

Abstract

Purpose: To assess the value of {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma as compared with PET and conventional imaging (CI) alone, and to assess the impact of PET/CT on further clinical management. Methods and Materials: Thirty-three patients with nasopharyngeal carcinoma had 45 PET/CT examinations. The study was a retrospective analysis. Changes in patient care resulting from the PET/CT studies were recorded. Results: Positron emission tomography/computed tomography had sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 92%, 90%, 90%, 90%, and 91%, respectively, as compared with 92%, 65%, 76%, 86%, and 80% for PET and 92%, 15%, 60%, 60%, and 60% for CI. Imaging with PET/CT altered further management of 19 patients (57%). Imaging with PET/CT eliminated the need for previously planned diagnostic procedures in 11 patients, induced a change in the planned therapeutic approach in 5 patients, and guided biopsy to a specific metabolically active area inside an edematous region in 3 patients, thus decreasing the chances for tissue sampling errors and avoiding damage to nonmalignant tissue. Conclusions: In cancer of the nasopharynx, the diagnostic performance of PET/CT is better than that of stand-alone PET or CI. Positron emission tomography/computedmore » tomography had a major impact on further clinical management in 57% of patients.« less

Authors:
 [1];  [2];  [3];  [4];  [4];  [5];  [4]
  1. Department of Otolaryngology, Rambam Health Care Campus, Haifa (Israel). E-mail: ariegor@hotmail.com
  2. Department of Otolaryngology, Rambam Health Care Campus, Haifa (Israel)
  3. Department of Diagnostic Imaging, Rambam Health Care Campus, Haifa (Israel)
  4. Department of Nuclear Medicine, Rambam Health Care Campus, Haifa (Israel)
  5. Department of Oncology, Rambam Health Care Campus, Haifa (Israel)
Publication Date:
OSTI Identifier:
20951654
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 68; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2006.12.028; PII: S0360-3016(06)03642-X; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ACCURACY; BIOPSY; CARCINOMAS; DAMAGE; ERRORS; FLUORINE 18; FLUORODEOXYGLUCOSE; PATIENTS; PHARYNX; POSITRON COMPUTED TOMOGRAPHY; RADIOTHERAPY

Citation Formats

Gordin, Arie, Golz, Avishay, Daitzchman, Marcello, Keidar, Zohar, Bar-Shalom, Rachel, Kuten, Abraham, and Israel, Ora. Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging in Patients With Carcinoma of the Nasopharynx: Diagnostic Accuracy and Impact on Clinical Management. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2006.12.028.
Gordin, Arie, Golz, Avishay, Daitzchman, Marcello, Keidar, Zohar, Bar-Shalom, Rachel, Kuten, Abraham, & Israel, Ora. Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging in Patients With Carcinoma of the Nasopharynx: Diagnostic Accuracy and Impact on Clinical Management. United States. doi:10.1016/j.ijrobp.2006.12.028.
Gordin, Arie, Golz, Avishay, Daitzchman, Marcello, Keidar, Zohar, Bar-Shalom, Rachel, Kuten, Abraham, and Israel, Ora. Fri . "Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging in Patients With Carcinoma of the Nasopharynx: Diagnostic Accuracy and Impact on Clinical Management". United States. doi:10.1016/j.ijrobp.2006.12.028.
@article{osti_20951654,
title = {Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging in Patients With Carcinoma of the Nasopharynx: Diagnostic Accuracy and Impact on Clinical Management},
author = {Gordin, Arie and Golz, Avishay and Daitzchman, Marcello and Keidar, Zohar and Bar-Shalom, Rachel and Kuten, Abraham and Israel, Ora},
abstractNote = {Purpose: To assess the value of {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma as compared with PET and conventional imaging (CI) alone, and to assess the impact of PET/CT on further clinical management. Methods and Materials: Thirty-three patients with nasopharyngeal carcinoma had 45 PET/CT examinations. The study was a retrospective analysis. Changes in patient care resulting from the PET/CT studies were recorded. Results: Positron emission tomography/computed tomography had sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 92%, 90%, 90%, 90%, and 91%, respectively, as compared with 92%, 65%, 76%, 86%, and 80% for PET and 92%, 15%, 60%, 60%, and 60% for CI. Imaging with PET/CT altered further management of 19 patients (57%). Imaging with PET/CT eliminated the need for previously planned diagnostic procedures in 11 patients, induced a change in the planned therapeutic approach in 5 patients, and guided biopsy to a specific metabolically active area inside an edematous region in 3 patients, thus decreasing the chances for tissue sampling errors and avoiding damage to nonmalignant tissue. Conclusions: In cancer of the nasopharynx, the diagnostic performance of PET/CT is better than that of stand-alone PET or CI. Positron emission tomography/computed tomography had a major impact on further clinical management in 57% of patients.},
doi = {10.1016/j.ijrobp.2006.12.028},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 2,
volume = 68,
place = {United States},
year = {Fri Jun 01 00:00:00 EDT 2007},
month = {Fri Jun 01 00:00:00 EDT 2007}
}