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Title: Feasibility of Image Registration and Intensity-Modulated Radiotherapy Planning With Hyperpolarized Helium-3 Magnetic Resonance Imaging for Non-Small-Cell Lung Cancer

Abstract

Purpose: To demonstrate the feasibility of registering hyperpolarized helium-3 magnetic resonance images ({sup 3}He-MRI) to X-ray computed tomography (CT) for functionally weighted intensity-modulated radiotherapy (IMRT) planning. Methods and Materials: Six patients with non-small-cell lung cancer underwent {sup 3}He ventilation MRI, which was fused with radiotherapy planning CT using rigid registration. Registration accuracy was assessed using an overlap coefficient, calculated as the proportion of the segmented {sup 3}He-MR volume (V{sub MRI} ) that intersects the segmented CT lung volume expressed as a percentage of V{sub MRI} . For each patient, an IMRT plan that minimized the volume of total lung receiving a dose {>=}20 Gy (V{sub 20} ) was compared with a plan that minimized the V{sub 20} to well-ventilated lung defined by the registered {sup 3}He-MRI. Results: The {sup 3}He-MRI and CT were registered with sufficient accuracy to enable functionally guided IMRT planning (median overlap, 89%; range, 72-97%). In comparison with the total lung IMRT plans, IMRT constrained with {sup 3}He-MRI reduced the V{sub 20} not only for the well-ventilated lung (median reduction, 3.1%; range, 0.4-5.1%; p = 0.028) but also for the total lung volume (median reduction, 1.6%; range, 0.2-3.7%; p 0.028). Conclusions: Statistically significant improvements to IMRT plansmore » are possible using functional information provided by {sup 3}He-MRI that has been registered to radiotherapy planning CT.« less

Authors:
 [1];  [2];  [3];  [4];  [3];  [5];  [5];  [5];  [6];  [5];  [7]
  1. Academic Unit of Radiology, University of Sheffield, Sheffield (United Kingdom) and Department of Radiotherapy Physics, Weston Park Hospital, Sheffield (United Kingdom). E-mail: r.ireland@sheffield.ac.uk
  2. Academic Unit of Medical Physics, University of Sheffield, Sheffield (United Kingdom)
  3. (United Kingdom)
  4. Department of Radiotherapy Physics, Weston Park Hospital, Sheffield (United Kingdom)
  5. Academic Unit of Radiology, University of Sheffield, Sheffield (United Kingdom)
  6. (United States)
  7. Academic Unit of Clinical Oncology, University of Sheffield, Sheffield (United Kingdom)
Publication Date:
OSTI Identifier:
20951643
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 68; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2006.12.068; PII: S0360-3016(07)00094-6; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ACCURACY; CARCINOMAS; COMPUTERIZED TOMOGRAPHY; HELIUM 3; IMAGES; LUNGS; NMR IMAGING; PATIENTS; PLANNING; RADIATION DOSES; RADIOTHERAPY; X RADIATION

Citation Formats

Ireland, Rob H., Bragg, Chris M., Department of Radiotherapy Physics, Weston Park Hospital, Sheffield, McJury, Mark, Department of Medical Physics, Belfast City Hospital Trust, Belfast, Northern Ireland, Woodhouse, Neil, Fichele, Stan, Beek, Edwin J.R. van, Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, Wild, Jim M., and Hatton, Matthew Q. Feasibility of Image Registration and Intensity-Modulated Radiotherapy Planning With Hyperpolarized Helium-3 Magnetic Resonance Imaging for Non-Small-Cell Lung Cancer. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2006.12.068.
Ireland, Rob H., Bragg, Chris M., Department of Radiotherapy Physics, Weston Park Hospital, Sheffield, McJury, Mark, Department of Medical Physics, Belfast City Hospital Trust, Belfast, Northern Ireland, Woodhouse, Neil, Fichele, Stan, Beek, Edwin J.R. van, Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, Wild, Jim M., & Hatton, Matthew Q. Feasibility of Image Registration and Intensity-Modulated Radiotherapy Planning With Hyperpolarized Helium-3 Magnetic Resonance Imaging for Non-Small-Cell Lung Cancer. United States. doi:10.1016/j.ijrobp.2006.12.068.
Ireland, Rob H., Bragg, Chris M., Department of Radiotherapy Physics, Weston Park Hospital, Sheffield, McJury, Mark, Department of Medical Physics, Belfast City Hospital Trust, Belfast, Northern Ireland, Woodhouse, Neil, Fichele, Stan, Beek, Edwin J.R. van, Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, Wild, Jim M., and Hatton, Matthew Q. Tue . "Feasibility of Image Registration and Intensity-Modulated Radiotherapy Planning With Hyperpolarized Helium-3 Magnetic Resonance Imaging for Non-Small-Cell Lung Cancer". United States. doi:10.1016/j.ijrobp.2006.12.068.
@article{osti_20951643,
title = {Feasibility of Image Registration and Intensity-Modulated Radiotherapy Planning With Hyperpolarized Helium-3 Magnetic Resonance Imaging for Non-Small-Cell Lung Cancer},
author = {Ireland, Rob H. and Bragg, Chris M. and Department of Radiotherapy Physics, Weston Park Hospital, Sheffield and McJury, Mark and Department of Medical Physics, Belfast City Hospital Trust, Belfast, Northern Ireland and Woodhouse, Neil and Fichele, Stan and Beek, Edwin J.R. van and Department of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA and Wild, Jim M. and Hatton, Matthew Q.},
abstractNote = {Purpose: To demonstrate the feasibility of registering hyperpolarized helium-3 magnetic resonance images ({sup 3}He-MRI) to X-ray computed tomography (CT) for functionally weighted intensity-modulated radiotherapy (IMRT) planning. Methods and Materials: Six patients with non-small-cell lung cancer underwent {sup 3}He ventilation MRI, which was fused with radiotherapy planning CT using rigid registration. Registration accuracy was assessed using an overlap coefficient, calculated as the proportion of the segmented {sup 3}He-MR volume (V{sub MRI} ) that intersects the segmented CT lung volume expressed as a percentage of V{sub MRI} . For each patient, an IMRT plan that minimized the volume of total lung receiving a dose {>=}20 Gy (V{sub 20} ) was compared with a plan that minimized the V{sub 20} to well-ventilated lung defined by the registered {sup 3}He-MRI. Results: The {sup 3}He-MRI and CT were registered with sufficient accuracy to enable functionally guided IMRT planning (median overlap, 89%; range, 72-97%). In comparison with the total lung IMRT plans, IMRT constrained with {sup 3}He-MRI reduced the V{sub 20} not only for the well-ventilated lung (median reduction, 3.1%; range, 0.4-5.1%; p = 0.028) but also for the total lung volume (median reduction, 1.6%; range, 0.2-3.7%; p 0.028). Conclusions: Statistically significant improvements to IMRT plans are possible using functional information provided by {sup 3}He-MRI that has been registered to radiotherapy planning CT.},
doi = {10.1016/j.ijrobp.2006.12.068},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 1,
volume = 68,
place = {United States},
year = {Tue May 01 00:00:00 EDT 2007},
month = {Tue May 01 00:00:00 EDT 2007}
}