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Title: Multicenter Validation of Recursive Partitioning Analysis Classification for Patients With Squamous Cell Head and Neck Carcinoma Treated With Surgery and Postoperative Radiotherapy

Abstract

Purpose: To validate the recursive partitioning analysis (RPA) classification system for squamous cell head and neck cancer as recently reported by the VU University Medical Center. Methods and Materials: In eight Dutch head and neck cancer centers, data necessary to classify patients according to the RPA system were retrospectively collected from the charts of a group of 780 patients treated between 1989 and 2003. The patients in this validation group were classified according to the RPA classification system. For each endpoint, the 5-year values and hazard ratios were calculated and compared with the results of the VU University Medical Center. The RPA classification system was considered valid if the hazard ratio of the validation population was within the 95% confidence interval of the VU University Medical Center study population. Results: The locoregional control rate was 82%, 75%, and 63% at 5 years for those with class I, II, and III, respectively (p < 0.0001). The hazard ratio for the locoregional control rate relative to class I was 1.44 (95% confidence interval, 0.97-2.16) for class II and 2.37 (95% confidence interval, 1.57-3.57) for class III. Similar results were found for the distant metastasis, overall survival, and disease-free survival rates. Conclusion: Themore » RPA classification system for head and neck squamous cell carcinoma in the postoperative setting, which was originally designed at one center, proved to be valid in a multicenter setting among patients included in a national multicenter study. This validated RPA classification scheme can be used to assess standard treatment strategies for head and neck squamous cell carcinoma in the postoperative setting, as well as in the design of future prospective studies.« less

Authors:
 [1];  [2];  [3];  [4];  [5];  [6];  [7];  [8];  [9];  [10]
  1. Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)
  2. Department of Radiation Oncology, Radboud University Nijmegen Medical Center, Nijmegen (Netherlands)
  3. Department of Radiation Oncology, University Medical Center Utrecht, Utrecht (Netherlands)
  4. Department of Radiation Oncology, Antoni van Leeuwenhoek Hospital/Netherlands Cancer Institute, Amsterdam (Netherlands)
  5. MAASTRO Clinic, Maastricht (Netherlands)
  6. Radiotherapy Institute Friesland, Leeuwarden (Netherlands)
  7. Arnhem Radiotherapy Institute, Arnhem (Netherlands)
  8. Department of Radiation Oncology, Leiden University Medical Center, Leiden (Netherlands)
  9. Department of Otolaryngology/Head and Neck Surgery, VU University Medical Center, Amsterdam (Netherlands)
  10. Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands). E-mail: j.a.langendijk@rt.umcg.nl
Publication Date:
OSTI Identifier:
20951622
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 68; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2006.12.002; PII: S0360-3016(06)03599-1; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; CLASSIFICATION; HEAD; METASTASES; NECK; PATIENTS; RADIOTHERAPY; SURGERY; VALIDATION

Citation Formats

Jonkman, Anja, Kaanders, Johannes, Terhaard, Chris H.J., Hoebers, Frank J.P., Ende, Piet L.A. van den, Wijers, Oda B., Verhoef, Lia C.G., Jong, Martin A. de, Leemans, C. Rene, and Langendijk, Johannes A. Multicenter Validation of Recursive Partitioning Analysis Classification for Patients With Squamous Cell Head and Neck Carcinoma Treated With Surgery and Postoperative Radiotherapy. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2006.12.002.
Jonkman, Anja, Kaanders, Johannes, Terhaard, Chris H.J., Hoebers, Frank J.P., Ende, Piet L.A. van den, Wijers, Oda B., Verhoef, Lia C.G., Jong, Martin A. de, Leemans, C. Rene, & Langendijk, Johannes A. Multicenter Validation of Recursive Partitioning Analysis Classification for Patients With Squamous Cell Head and Neck Carcinoma Treated With Surgery and Postoperative Radiotherapy. United States. doi:10.1016/j.ijrobp.2006.12.002.
Jonkman, Anja, Kaanders, Johannes, Terhaard, Chris H.J., Hoebers, Frank J.P., Ende, Piet L.A. van den, Wijers, Oda B., Verhoef, Lia C.G., Jong, Martin A. de, Leemans, C. Rene, and Langendijk, Johannes A. Tue . "Multicenter Validation of Recursive Partitioning Analysis Classification for Patients With Squamous Cell Head and Neck Carcinoma Treated With Surgery and Postoperative Radiotherapy". United States. doi:10.1016/j.ijrobp.2006.12.002.
@article{osti_20951622,
title = {Multicenter Validation of Recursive Partitioning Analysis Classification for Patients With Squamous Cell Head and Neck Carcinoma Treated With Surgery and Postoperative Radiotherapy},
author = {Jonkman, Anja and Kaanders, Johannes and Terhaard, Chris H.J. and Hoebers, Frank J.P. and Ende, Piet L.A. van den and Wijers, Oda B. and Verhoef, Lia C.G. and Jong, Martin A. de and Leemans, C. Rene and Langendijk, Johannes A.},
abstractNote = {Purpose: To validate the recursive partitioning analysis (RPA) classification system for squamous cell head and neck cancer as recently reported by the VU University Medical Center. Methods and Materials: In eight Dutch head and neck cancer centers, data necessary to classify patients according to the RPA system were retrospectively collected from the charts of a group of 780 patients treated between 1989 and 2003. The patients in this validation group were classified according to the RPA classification system. For each endpoint, the 5-year values and hazard ratios were calculated and compared with the results of the VU University Medical Center. The RPA classification system was considered valid if the hazard ratio of the validation population was within the 95% confidence interval of the VU University Medical Center study population. Results: The locoregional control rate was 82%, 75%, and 63% at 5 years for those with class I, II, and III, respectively (p < 0.0001). The hazard ratio for the locoregional control rate relative to class I was 1.44 (95% confidence interval, 0.97-2.16) for class II and 2.37 (95% confidence interval, 1.57-3.57) for class III. Similar results were found for the distant metastasis, overall survival, and disease-free survival rates. Conclusion: The RPA classification system for head and neck squamous cell carcinoma in the postoperative setting, which was originally designed at one center, proved to be valid in a multicenter setting among patients included in a national multicenter study. This validated RPA classification scheme can be used to assess standard treatment strategies for head and neck squamous cell carcinoma in the postoperative setting, as well as in the design of future prospective studies.},
doi = {10.1016/j.ijrobp.2006.12.002},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 1,
volume = 68,
place = {United States},
year = {Tue May 01 00:00:00 EDT 2007},
month = {Tue May 01 00:00:00 EDT 2007}
}