Active Breathing Control for Hodgkin's Disease in Childhood and Adolescence: Feasibility, Advantages, and Limits

doi:10.1016/j.ijrobp.2006.11.008

Title: Active Breathing Control for Hodgkin's Disease in Childhood and Adolescence: Feasibility, Advantages, and Limits

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Abstract

Purpose: The challenge in early Hodgkin's disease (HD) in children is to maintain good survival rates while sparing organs at risk. This study assesses the feasibility of active breathing control (ABC) in children, and compares normal tissue irradiation with and without ABC. Methods and Materials: Between May 2003 and June 2004, seven children with HD with mediastinal involvement, median age 15, were treated by chemotherapy and involved-field radiation therapy. A free-breathing computed tomography simulation scan and one additional scan during deep inspiration using ABC were performed. A comparison between planning treatment with clinical target volume including supraclavicular regions, mediastinum, and hila was performed, both in free breathing and using ABC. Results: For a prescription of 36 Gy, pulmonary dose-volume histograms revealed a mean reduction in lung volume irradiated at more than 20 Gy (V20) and 30 Gy (V30) of 25% and 26%, respectively, using ABC (p = 0.016). The mean volume of heart irradiated at 30 Gy or more decreased from 15% to 12% (nonsignificant). The mean dose delivered to breasts in girls was small in both situations (less than 2 Gy) and stable with or without ABC. Considering axillary irradiation, the mean dose delivered to breasts remained low (<9more »« less

Authors:

Claude, Line ^[1]; Malet, Claude Phys. ^[2]; Pommier, Pascal ^[2]; Thiesse, Philippe ^[3]; Chabaud, Sylvie ^[4]; Carrie, Christian ^[2]

Department of Radiotherapy, Centre Leon Berard, Lyon (France). E-mail: claude@lyon.fnclcc.fr
Department of Radiotherapy, Centre Leon Berard, Lyon (France)
Department of Radiology, Centre Leon Berard, Lyon (France)
Department of Public Health (UBET), Centre Leon Berard, Lyon (France)

Publication Date:: Sun Apr 01 00:00:00 EDT 2007

OSTI Identifier:: 20951593

Resource Type:: Journal Article

Resource Relation:: Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 67; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2006.11.008; PII: S0360-3016(06)03366-9; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; CHEMOTHERAPY; CHILDREN; COMPUTERIZED TOMOGRAPHY; HEART; IRRADIATION; LUNGS; MAMMARY GLANDS; PEDIATRICS; RADIATION DOSES; RADIOTHERAPY; RESPIRATION; SIMULATION; THYROID

Citation Formats


                    Claude, Line, Malet, Claude Phys., Pommier, Pascal, Thiesse, Philippe, Chabaud, Sylvie, and Carrie, Christian. Active Breathing Control for Hodgkin's Disease in Childhood and Adolescence: Feasibility, Advantages, and Limits.  United States: N. p., 2007. 
        Web.  doi:10.1016/j.ijrobp.2006.11.008.

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                    Claude, Line, Malet, Claude Phys., Pommier, Pascal, Thiesse, Philippe, Chabaud, Sylvie, & Carrie, Christian. Active Breathing Control for Hodgkin's Disease in Childhood and Adolescence: Feasibility, Advantages, and Limits.  United States.  doi:10.1016/j.ijrobp.2006.11.008.

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                    Claude, Line, Malet, Claude Phys., Pommier, Pascal, Thiesse, Philippe, Chabaud, Sylvie, and Carrie, Christian. Sun .  
        "Active Breathing Control for Hodgkin's Disease in Childhood and Adolescence: Feasibility, Advantages, and Limits".  United States.  
        doi:10.1016/j.ijrobp.2006.11.008.

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@article{osti_20951593,

  title        = {Active Breathing Control for Hodgkin's Disease in Childhood and Adolescence: Feasibility, Advantages, and Limits},

  author       = {Claude, Line and Malet, Claude Phys. and Pommier, Pascal and Thiesse, Philippe and Chabaud, Sylvie and Carrie, Christian},

  abstractNote = {Purpose: The challenge in early Hodgkin's disease (HD) in children is to maintain good survival rates while sparing organs at risk. This study assesses the feasibility of active breathing control (ABC) in children, and compares normal tissue irradiation with and without ABC. Methods and Materials: Between May 2003 and June 2004, seven children with HD with mediastinal involvement, median age 15, were treated by chemotherapy and involved-field radiation therapy. A free-breathing computed tomography simulation scan and one additional scan during deep inspiration using ABC were performed. A comparison between planning treatment with clinical target volume including supraclavicular regions, mediastinum, and hila was performed, both in free breathing and using ABC. Results: For a prescription of 36 Gy, pulmonary dose-volume histograms revealed a mean reduction in lung volume irradiated at more than 20 Gy (V20) and 30 Gy (V30) of 25% and 26%, respectively, using ABC (p = 0.016). The mean volume of heart irradiated at 30 Gy or more decreased from 15% to 12% (nonsignificant). The mean dose delivered to breasts in girls was small in both situations (less than 2 Gy) and stable with or without ABC. Considering axillary irradiation, the mean dose delivered to breasts remained low (<9 Gy), without significant difference using ABC or not. The mean radiation dose delivered to thyroid was stable using ABC or not. Conclusions: Using ABC is feasible in childhood. The use of ABC decreases normal lung tissue irradiation. Concerning heart irradiation, a minimal gain is also shown. No significant change has been demonstrated concerning breast and thyroid irradiation.},

  doi          = {10.1016/j.ijrobp.2006.11.008},

  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  number       = 5,

  volume       = 67,

  place        = {United States},

  year         = {Sun Apr 01 00:00:00 EDT 2007},

  month        = {Sun Apr 01 00:00:00 EDT 2007}

}

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DOI: 10.1016/j.ijrobp.2006.11.008

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