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Title: The Failure Patterns of Oral Cavity Squamous Cell Carcinoma After Intensity-Modulated Radiotherapy-University of Iowa Experience

Abstract

Purpose: Determine the failure patterns of oral cavity squamous cell carcinoma (SCC) treated with intensity-modulated radiotherapy (IMRT). Methods and Materials: Between May 2001 and July 2005, 55 patients with oral cavity SCC were treated with IMRT for curative intent. Forty-nine received postoperative IMRT, 5 definitive IMRT, and 1 neoadjuvant. Three target volumes were defined (clinical target CTV1, CTV2, and CTV3). The failure patterns were determined by coregistration or comparison of the treatment planning computed tomography to the images obtained at the time of recurrence. Results: The median follow-up for all patients was 17.1 months (range, 0.27-59.3 months). The median follow-up for living patients was 23.9 months (range, 9.3-59.3 months). Nine patients had locoregional failures: 4 local failures only, 2 regional failures only, and 3 had both local and regional failures. Five patients failed distantly; of these, 3 also had locoregional failures. The 2-year overall survival, disease-specific survival, local recurrence-free survival, locoregional recurrence-free survival, and distant disease-free survival was 68%, 74%, 85%, 82%, and 89%, respectively. The median time from treatment completion to locoregional recurrence was 4.1 months (range, 3.0-12.1 months). Except for 1 patient who failed in contralateral lower neck outside the radiation field, all failed in areas that hadmore » received a high dose of radiation. The locoregional control is strongly correlated with extracapsular extension. Conclusions: Intensity-modulated RT is effective for oral cavity SCC. Most failures are in-field failures. Further clinical studies are necessary to improve the outcomes of patients with high-risk features, particularly for those with extracapsular extension.« less

Authors:
 [1];  [2];  [3];  [4];  [3];  [5];  [3];  [3];  [4];  [3];  [4]
  1. Department of Radiation Oncology, University of Iowa Health Care, Iowa City, IA (United States) and Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA (United States). E-mail: min-yao@uiowa.edu
  2. Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA (United States)
  3. Department of Radiation Oncology, University of Iowa Health Care, Iowa City, IA (United States)
  4. (United States)
  5. Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA (United States)
Publication Date:
OSTI Identifier:
20951575
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 67; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2006.11.030; PII: S0360-3016(06)03507-3; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; COMPUTERIZED TOMOGRAPHY; FAILURES; IMAGES; IOWA; NECK; ORAL CAVITY; PATIENTS; PLANNING; RADIATION DOSES; RADIOTHERAPY

Citation Formats

Yao Min, Chang, Kristi, Funk, Gerry F., Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA, Lu Heming, Tan Huaming, Wacha, Judith C, Dornfeld, Kenneth J., Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA, Buatti, John M., and Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA. The Failure Patterns of Oral Cavity Squamous Cell Carcinoma After Intensity-Modulated Radiotherapy-University of Iowa Experience. United States: N. p., 2007. Web.
Yao Min, Chang, Kristi, Funk, Gerry F., Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA, Lu Heming, Tan Huaming, Wacha, Judith C, Dornfeld, Kenneth J., Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA, Buatti, John M., & Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA. The Failure Patterns of Oral Cavity Squamous Cell Carcinoma After Intensity-Modulated Radiotherapy-University of Iowa Experience. United States.
Yao Min, Chang, Kristi, Funk, Gerry F., Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA, Lu Heming, Tan Huaming, Wacha, Judith C, Dornfeld, Kenneth J., Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA, Buatti, John M., and Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA. Sun . "The Failure Patterns of Oral Cavity Squamous Cell Carcinoma After Intensity-Modulated Radiotherapy-University of Iowa Experience". United States. doi:.
@article{osti_20951575,
title = {The Failure Patterns of Oral Cavity Squamous Cell Carcinoma After Intensity-Modulated Radiotherapy-University of Iowa Experience},
author = {Yao Min and Chang, Kristi and Funk, Gerry F. and Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA and Lu Heming and Tan Huaming and Wacha, Judith C and Dornfeld, Kenneth J. and Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA and Buatti, John M. and Department of Otolaryngology, University of Iowa Health Care, Iowa City, IA},
abstractNote = {Purpose: Determine the failure patterns of oral cavity squamous cell carcinoma (SCC) treated with intensity-modulated radiotherapy (IMRT). Methods and Materials: Between May 2001 and July 2005, 55 patients with oral cavity SCC were treated with IMRT for curative intent. Forty-nine received postoperative IMRT, 5 definitive IMRT, and 1 neoadjuvant. Three target volumes were defined (clinical target CTV1, CTV2, and CTV3). The failure patterns were determined by coregistration or comparison of the treatment planning computed tomography to the images obtained at the time of recurrence. Results: The median follow-up for all patients was 17.1 months (range, 0.27-59.3 months). The median follow-up for living patients was 23.9 months (range, 9.3-59.3 months). Nine patients had locoregional failures: 4 local failures only, 2 regional failures only, and 3 had both local and regional failures. Five patients failed distantly; of these, 3 also had locoregional failures. The 2-year overall survival, disease-specific survival, local recurrence-free survival, locoregional recurrence-free survival, and distant disease-free survival was 68%, 74%, 85%, 82%, and 89%, respectively. The median time from treatment completion to locoregional recurrence was 4.1 months (range, 3.0-12.1 months). Except for 1 patient who failed in contralateral lower neck outside the radiation field, all failed in areas that had received a high dose of radiation. The locoregional control is strongly correlated with extracapsular extension. Conclusions: Intensity-modulated RT is effective for oral cavity SCC. Most failures are in-field failures. Further clinical studies are necessary to improve the outcomes of patients with high-risk features, particularly for those with extracapsular extension.},
doi = {},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 67,
place = {United States},
year = {Sun Apr 01 00:00:00 EDT 2007},
month = {Sun Apr 01 00:00:00 EDT 2007}
}