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Title: Monte Carlo simulations of absorbed dose in a mouse phantom from 18-fluorine compounds

Abstract

The purpose of this study was to calculate internal absorbed dose distribution in mice from preclinical small animal PET imaging procedures with fluorine-18 labeled compounds ({sup 18}FDG, {sup 18}FLT, and fluoride ion). The GATE Monte Carlo software and a realistic, voxel-based mouse phantom that included a subcutaneous tumor were used to perform simulations. Discretized time-activity curves obtained from dynamic in vivo studies with each of the compounds were used to set the activity concentration in the simulations. For {sup 18}FDG, a realistic range of uptake ratios was considered for the heart and tumor. For each simulated time frame, the biodistribution of the radionuclide in the phantom was considered constant, and a sufficient number of decays were simulated to achieve low statistical uncertainty. Absorbed dose, which was scaled to take into account radioactive decay, integration with time, and changes in biological distribution was reported in mGy per MBq of administered activity for several organs and uptake scenarios. The mean absorbed dose ranged from a few mGy/MBq to hundreds of mGy/MBq. Major organs receive an absorbed dose in a range for which biological effects have been reported. The effects on a given investigation are hard to predict; however, investigators should be awaremore » of potential perturbations especially when the studied organ receives high absorbed dose and when longitudinal imaging protocols are considered.« less

Authors:
;  [1]
  1. Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, 700 Westwood Boulevard, Los Angeles, California 90095 (United States)
Publication Date:
OSTI Identifier:
20951092
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 34; Journal Issue: 3; Other Information: DOI: 10.1118/1.2558115; (c) 2007 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BIOLOGICAL RADIATION EFFECTS; COMPUTER CODES; COMPUTERIZED SIMULATION; DOSIMETRY; FLUORINE 18; HEART; IN VIVO; IONIZING RADIATIONS; LABELLED COMPOUNDS; MICE; MONTE CARLO METHOD; NEOPLASMS; NUCLEAR DECAY; PHANTOMS; POSITRON COMPUTED TOMOGRAPHY; RADIATION DOSES; UPTAKE

Citation Formats

Taschereau, Richard, and Chatziioannou, Arion F. Monte Carlo simulations of absorbed dose in a mouse phantom from 18-fluorine compounds. United States: N. p., 2007. Web. doi:10.1118/1.2558115.
Taschereau, Richard, & Chatziioannou, Arion F. Monte Carlo simulations of absorbed dose in a mouse phantom from 18-fluorine compounds. United States. doi:10.1118/1.2558115.
Taschereau, Richard, and Chatziioannou, Arion F. Thu . "Monte Carlo simulations of absorbed dose in a mouse phantom from 18-fluorine compounds". United States. doi:10.1118/1.2558115.
@article{osti_20951092,
title = {Monte Carlo simulations of absorbed dose in a mouse phantom from 18-fluorine compounds},
author = {Taschereau, Richard and Chatziioannou, Arion F.},
abstractNote = {The purpose of this study was to calculate internal absorbed dose distribution in mice from preclinical small animal PET imaging procedures with fluorine-18 labeled compounds ({sup 18}FDG, {sup 18}FLT, and fluoride ion). The GATE Monte Carlo software and a realistic, voxel-based mouse phantom that included a subcutaneous tumor were used to perform simulations. Discretized time-activity curves obtained from dynamic in vivo studies with each of the compounds were used to set the activity concentration in the simulations. For {sup 18}FDG, a realistic range of uptake ratios was considered for the heart and tumor. For each simulated time frame, the biodistribution of the radionuclide in the phantom was considered constant, and a sufficient number of decays were simulated to achieve low statistical uncertainty. Absorbed dose, which was scaled to take into account radioactive decay, integration with time, and changes in biological distribution was reported in mGy per MBq of administered activity for several organs and uptake scenarios. The mean absorbed dose ranged from a few mGy/MBq to hundreds of mGy/MBq. Major organs receive an absorbed dose in a range for which biological effects have been reported. The effects on a given investigation are hard to predict; however, investigators should be aware of potential perturbations especially when the studied organ receives high absorbed dose and when longitudinal imaging protocols are considered.},
doi = {10.1118/1.2558115},
journal = {Medical Physics},
number = 3,
volume = 34,
place = {United States},
year = {Thu Mar 15 00:00:00 EDT 2007},
month = {Thu Mar 15 00:00:00 EDT 2007}
}