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Title: Effect of epidermal growth factor against radiotherapy-induced oral mucositis in rats

Abstract

Purpose: We tested the efficacy of oral recombinant human epidermal growth factor (rhEGF) against radiation-induced oral mucositis in a rat model. Methods and Materials: Each of 35 Sprague-Dawley rats, 7 to 8 weeks of age and weighing 178 {+-} 5 grams, was irradiated once in the head region with 25 Gy, using a 4-MV therapeutic linear accelerator at a rate of 2 Gy/min. The irradiated rats were randomly divided into four groups: those receiving no treatment (Group 1), those treated with vehicle only three times per day (Group 2), and those treated with 50 {mu}g/mL (Group 3), or 100 {mu}g/mL (Group 4) rhEGF three times per day. Results: Rats were monitored for survival rate and daily activity, including hair loss, sensitivity, and anorexia. We found that survival rate and oral intake were significantly increased and histologic changes were significantly decreased in the rhEGF-treated rats. There was no difference, however, between rats treated with 50 {mu}g/mL or 100 {mu}g/mL rhEGF. Conclusion: These findings suggest that orally administered rhEGF decreased radiation-induced oral mucositis in rats.

Authors:
 [1];  [2];  [3];  [3];  [4];  [5]
  1. Department of Radiation Oncology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul (Korea, Republic of)
  2. Research Institute of Daewoong Pharmaceutical Company, Kyungkido (Korea, Republic of)
  3. Asan Institute of Life Sciences, Seoul (Korea, Republic of)
  4. Department of Radiology, Gyeongsang National University, College of Medicine, Jinju (Korea, Republic of)
  5. Department of Plastic and Reconstructive Surgery, University of Ulsan, College of Medicine, Asan Medical Center, Seoul (Korea, Republic of). E-mail: joonphong@amc.seoul.kr
Publication Date:
OSTI Identifier:
20944777
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 67; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2006.10.038; PII: S0360-3016(06)03367-0; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ANOREXIA; BIOLOGICAL RADIATION EFFECTS; GROWTH FACTORS; HAIR; HEAD; IRRADIATION; LINEAR ACCELERATORS; RADIOTHERAPY; RATS; SENSITIVITY

Citation Formats

Lee, Sang-wook, Jung, Kwon Il, Kim, Yeun Wha B.S., Jung, Heun Don, Kim, Hyun Sook, and Hong, Joon Pio. Effect of epidermal growth factor against radiotherapy-induced oral mucositis in rats. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2006.10.038.
Lee, Sang-wook, Jung, Kwon Il, Kim, Yeun Wha B.S., Jung, Heun Don, Kim, Hyun Sook, & Hong, Joon Pio. Effect of epidermal growth factor against radiotherapy-induced oral mucositis in rats. United States. doi:10.1016/j.ijrobp.2006.10.038.
Lee, Sang-wook, Jung, Kwon Il, Kim, Yeun Wha B.S., Jung, Heun Don, Kim, Hyun Sook, and Hong, Joon Pio. Thu . "Effect of epidermal growth factor against radiotherapy-induced oral mucositis in rats". United States. doi:10.1016/j.ijrobp.2006.10.038.
@article{osti_20944777,
title = {Effect of epidermal growth factor against radiotherapy-induced oral mucositis in rats},
author = {Lee, Sang-wook and Jung, Kwon Il and Kim, Yeun Wha B.S. and Jung, Heun Don and Kim, Hyun Sook and Hong, Joon Pio},
abstractNote = {Purpose: We tested the efficacy of oral recombinant human epidermal growth factor (rhEGF) against radiation-induced oral mucositis in a rat model. Methods and Materials: Each of 35 Sprague-Dawley rats, 7 to 8 weeks of age and weighing 178 {+-} 5 grams, was irradiated once in the head region with 25 Gy, using a 4-MV therapeutic linear accelerator at a rate of 2 Gy/min. The irradiated rats were randomly divided into four groups: those receiving no treatment (Group 1), those treated with vehicle only three times per day (Group 2), and those treated with 50 {mu}g/mL (Group 3), or 100 {mu}g/mL (Group 4) rhEGF three times per day. Results: Rats were monitored for survival rate and daily activity, including hair loss, sensitivity, and anorexia. We found that survival rate and oral intake were significantly increased and histologic changes were significantly decreased in the rhEGF-treated rats. There was no difference, however, between rats treated with 50 {mu}g/mL or 100 {mu}g/mL rhEGF. Conclusion: These findings suggest that orally administered rhEGF decreased radiation-induced oral mucositis in rats.},
doi = {10.1016/j.ijrobp.2006.10.038},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 4,
volume = 67,
place = {United States},
year = {Thu Mar 15 00:00:00 EDT 2007},
month = {Thu Mar 15 00:00:00 EDT 2007}
}