Multi-institutional clinical experience with the Calypso System in localization and continuous, real-time monitoring of the prostate gland during external radiotherapy
- M. D. Anderson Cancer Center Orlando, Orlando, FL (United States)
- Cleveland Clinic Foundation, Cleveland, OH (United States)
- Sharp Memorial Hospital, San Diego, CA (United States)
- Nebraska Medical Center, Omaha, NE (United States)
- Scottsdale Healthcare/Arizona Oncology Services, Scottsdale, AZ (United States)
- Calypso Medical Technologies, Inc., Seattle, WA (United States)
Purpose: To report the clinical experience with an electromagnetic treatment target positioning and continuous monitoring system in patients with localized prostate cancer receiving external beam radiotherapy. Methods and Materials: The Calypso System is a target positioning device that continuously monitors the location of three implanted electromagnetic transponders at a rate of 10 Hz. The system was used at five centers to position 41 patients over a full course of therapy. Electromagnetic positioning was compared to setup using skin marks and to stereoscopic X-ray localization of the transponders. Continuous monitoring was performed in 35 patients. Results: The difference between skin mark vs. the Calypso System alignment was found to be >5 mm in vector length in more than 75% of fractions. Comparisons between the Calypso System and X-ray localization showed good agreement. Qualitatively, the continuous motion was unpredictable and varied from persistent drift to transient rapid movements. Displacements {>=}3 and {>=}5 mm for cumulative durations of at least 30 s were observed during 41% and 15% of sessions. In individual patients, the number of fractions with displacements {>=}3 mm ranged from 3% to 87%; whereas the number of fractions with displacements {>=}5 mm ranged from 0% to 56%. Conclusion: The Calypso System is a clinically efficient and objective localization method for positioning prostate patients undergoing radiotherapy. Initial treatment setup can be performed rapidly, accurately, and objectively before radiation delivery. The extent and frequency of prostate motion during radiotherapy delivery can be easily monitored and used for motion management.
- OSTI ID:
- 20944767
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics, Vol. 67, Issue 4; Other Information: DOI: 10.1016/j.ijrobp.2006.10.026; PII: S0360-3016(06)03276-7; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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