skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Clinical implications of defining the gross tumor volume with combination of CT and {sup 18}FDG-positron emission tomography in non-small-cell lung cancer

Abstract

Purpose: To compare the planning target volume (PTV) definitions for computed tomography (CT) vs. positron emission tomography (PET) in non-small-cell lung cancer (NSCLC). Methods and Materials: A total of 21 patients with NSCLC underwent three-dimensional conformal radiotherapy planning. All underwent a staging F-18 fluorodeoxyglucose-position emission tomography ({sup 18}FDG-PET) scan and underwent treatment simulation using CT plus a separate planning {sup 18}FDG-PET scan. Three sets of target volumes were defined: Set 1, CT volumes (CT tumor + staging PET nodal disease); Set 2, PET volumes (planning PET tumor {l_brace}gross tumor volume (GTV) = [(0.3069 x mean standardized uptake value) + 0.5853]){r_brace}; Set 3, composite CT-PET volumes (fused CT-PET tumor). Sets 1 and 2 were compared using a matching index. Three-dimensional conformal radiotherapy plans were created using the Set 1 (CT) volumes; and coverage of the Set 3 (composite) volumes was evaluated. Separate three-dimensional conformal radiotherapy plans were designed for the Set 3 volumes. Results: For the primary tumor GTV, the Set 1 (CT) volume was larger than the Set 2 (PET) volume in 48%, smaller in 33%, and equal in 19%. The mean matching index was 0.65 (35% CT-PET mismatch). Although quantitatively similar, the volumes differed qualitatively. The Set 3 (composite)more » volume was larger than either CT or PET alone in 62%, smaller in 24%, and equal in 14%. The dose-volume histogram parameters did not differ among the plans for Set 1 (CT) vs. Set 3 (composite) volumes. Small portions of the Set 3 PTV were significantly underdosed in 40% of cases using the CT-only plan. Conclusion: Computed tomography and PET are complementary and should be obtained in the treatment position and fused to define the GTV for NSCLC. Although the quantitative absolute target volume is sometimes similar, the qualitative target locations can be substantially different, leading to underdosage of the target when planning is done using CT alone without PET fusion.« less

Authors:
 [1];  [2];  [2];  [2];  [2];  [2]
  1. Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States). E-mail: igrills@beaumont.edu
  2. Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, MI (United States)
Publication Date:
OSTI Identifier:
20944720
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 67; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2006.09.046; PII: S0360-3016(06)03240-8; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; FLUORINE 18; FLUORODEOXYGLUCOSE; LUNGS; NEOPLASMS; PATIENTS; PLANNING; POSITRON COMPUTED TOMOGRAPHY; RADIATION DOSES; RADIOTHERAPY; UPTAKE

Citation Formats

Grills, Inga S., Yan Di, Black, Quinten C., Wong, Ching-Yee O., Martinez, Alvaro A., and Kestin, Larry L.. Clinical implications of defining the gross tumor volume with combination of CT and {sup 18}FDG-positron emission tomography in non-small-cell lung cancer. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2006.09.046.
Grills, Inga S., Yan Di, Black, Quinten C., Wong, Ching-Yee O., Martinez, Alvaro A., & Kestin, Larry L.. Clinical implications of defining the gross tumor volume with combination of CT and {sup 18}FDG-positron emission tomography in non-small-cell lung cancer. United States. doi:10.1016/j.ijrobp.2006.09.046.
Grills, Inga S., Yan Di, Black, Quinten C., Wong, Ching-Yee O., Martinez, Alvaro A., and Kestin, Larry L.. Thu . "Clinical implications of defining the gross tumor volume with combination of CT and {sup 18}FDG-positron emission tomography in non-small-cell lung cancer". United States. doi:10.1016/j.ijrobp.2006.09.046.
@article{osti_20944720,
title = {Clinical implications of defining the gross tumor volume with combination of CT and {sup 18}FDG-positron emission tomography in non-small-cell lung cancer},
author = {Grills, Inga S. and Yan Di and Black, Quinten C. and Wong, Ching-Yee O. and Martinez, Alvaro A. and Kestin, Larry L.},
abstractNote = {Purpose: To compare the planning target volume (PTV) definitions for computed tomography (CT) vs. positron emission tomography (PET) in non-small-cell lung cancer (NSCLC). Methods and Materials: A total of 21 patients with NSCLC underwent three-dimensional conformal radiotherapy planning. All underwent a staging F-18 fluorodeoxyglucose-position emission tomography ({sup 18}FDG-PET) scan and underwent treatment simulation using CT plus a separate planning {sup 18}FDG-PET scan. Three sets of target volumes were defined: Set 1, CT volumes (CT tumor + staging PET nodal disease); Set 2, PET volumes (planning PET tumor {l_brace}gross tumor volume (GTV) = [(0.3069 x mean standardized uptake value) + 0.5853]){r_brace}; Set 3, composite CT-PET volumes (fused CT-PET tumor). Sets 1 and 2 were compared using a matching index. Three-dimensional conformal radiotherapy plans were created using the Set 1 (CT) volumes; and coverage of the Set 3 (composite) volumes was evaluated. Separate three-dimensional conformal radiotherapy plans were designed for the Set 3 volumes. Results: For the primary tumor GTV, the Set 1 (CT) volume was larger than the Set 2 (PET) volume in 48%, smaller in 33%, and equal in 19%. The mean matching index was 0.65 (35% CT-PET mismatch). Although quantitatively similar, the volumes differed qualitatively. The Set 3 (composite) volume was larger than either CT or PET alone in 62%, smaller in 24%, and equal in 14%. The dose-volume histogram parameters did not differ among the plans for Set 1 (CT) vs. Set 3 (composite) volumes. Small portions of the Set 3 PTV were significantly underdosed in 40% of cases using the CT-only plan. Conclusion: Computed tomography and PET are complementary and should be obtained in the treatment position and fused to define the GTV for NSCLC. Although the quantitative absolute target volume is sometimes similar, the qualitative target locations can be substantially different, leading to underdosage of the target when planning is done using CT alone without PET fusion.},
doi = {10.1016/j.ijrobp.2006.09.046},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 3,
volume = 67,
place = {United States},
year = {Thu Mar 01 00:00:00 EST 2007},
month = {Thu Mar 01 00:00:00 EST 2007}
}