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Title: Radiotherapy for malignancy in patients with scleroderma: The Mayo Clinic experience

Abstract

Purpose: To determine the frequency of acute and chronic adverse effects in patients with scleroderma who receive radiotherapy for treatment of cancer. Methods and Materials: Records were reviewed of 20 patients with scleroderma who received radiotherapy. Acute and chronic toxic effects attributable to radiotherapy were analyzed, and freedom from radiation-related toxicity was calculated. Results: Of the 20 patients, 15 had acute toxic effects, with Grade 3 or higher toxicity for 3 patients. Seven patients had self-limited Grade 1 or 2 radiation dermatitis, and no patient had Grade 3 or higher radiation dermatitis. Thirteen patients had chronic toxic effects, with Grade 3 or higher chronic toxicity for 3 patients. The median estimated time to any grade chronic toxicity was 0.4 years, and the median estimated time to Grade 3 or higher chronic toxicity has not been reached. Conclusions: The results suggest that although some patients with scleroderma treated with radiation experience considerable toxic effects, the occurrence of Grade 3 or higher toxicity may be less than previously anticipated.

Authors:
 [1];  [1];  [1];  [2]
  1. Department of Radiation Oncology, Mayo Clinic, Rochester, MN (United States)
  2. Division of Rheumatology, Mayo Clinic, Rochester, MN (United States)
Publication Date:
OSTI Identifier:
20944702
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 67; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2006.09.003; PII: S0360-3016(06)02966-X; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; CONNECTIVE TISSUE; DERMATITIS; PATIENTS; RADIOTHERAPY; TOXICITY

Citation Formats

Gold, Douglas G., Miller, Robert C., Petersen, Ivy A., and Osborn, Thomas G. Radiotherapy for malignancy in patients with scleroderma: The Mayo Clinic experience. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2006.09.003.
Gold, Douglas G., Miller, Robert C., Petersen, Ivy A., & Osborn, Thomas G. Radiotherapy for malignancy in patients with scleroderma: The Mayo Clinic experience. United States. doi:10.1016/j.ijrobp.2006.09.003.
Gold, Douglas G., Miller, Robert C., Petersen, Ivy A., and Osborn, Thomas G. Thu . "Radiotherapy for malignancy in patients with scleroderma: The Mayo Clinic experience". United States. doi:10.1016/j.ijrobp.2006.09.003.
@article{osti_20944702,
title = {Radiotherapy for malignancy in patients with scleroderma: The Mayo Clinic experience},
author = {Gold, Douglas G. and Miller, Robert C. and Petersen, Ivy A. and Osborn, Thomas G.},
abstractNote = {Purpose: To determine the frequency of acute and chronic adverse effects in patients with scleroderma who receive radiotherapy for treatment of cancer. Methods and Materials: Records were reviewed of 20 patients with scleroderma who received radiotherapy. Acute and chronic toxic effects attributable to radiotherapy were analyzed, and freedom from radiation-related toxicity was calculated. Results: Of the 20 patients, 15 had acute toxic effects, with Grade 3 or higher toxicity for 3 patients. Seven patients had self-limited Grade 1 or 2 radiation dermatitis, and no patient had Grade 3 or higher radiation dermatitis. Thirteen patients had chronic toxic effects, with Grade 3 or higher chronic toxicity for 3 patients. The median estimated time to any grade chronic toxicity was 0.4 years, and the median estimated time to Grade 3 or higher chronic toxicity has not been reached. Conclusions: The results suggest that although some patients with scleroderma treated with radiation experience considerable toxic effects, the occurrence of Grade 3 or higher toxicity may be less than previously anticipated.},
doi = {10.1016/j.ijrobp.2006.09.003},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 2,
volume = 67,
place = {United States},
year = {Thu Feb 01 00:00:00 EST 2007},
month = {Thu Feb 01 00:00:00 EST 2007}
}