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Title: Micromachined piconewton force sensor for biophysics investigations

Abstract

We describe a micromachined force sensor that is able to measure forces as small as 1 pN in both air and water. First, we measured the force field produced by an electromagnet on individual 2.8 {mu}m magnetic beads glued to the sensor. By repeating with 11 different beads, we measured a 9% standard deviation in saturation magnetization. We next demonstrated that the sensor was fully functional when immersed in physiological buffer. These results show that the force sensors can be useful for magnetic force calibration and also for measurement of biophysical forces on chip.

Authors:
; ; ;  [1]
  1. Sandia National Laboratories, Albuquerque, New Mexico 87185 (United States)
Publication Date:
OSTI Identifier:
20880061
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Physics Letters; Journal Volume: 89; Journal Issue: 17; Other Information: DOI: 10.1063/1.2364118; (c) 2006 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; AIR; BIOPHYSICS; CALIBRATION; ELECTROMAGNETS; MAGNETIZATION; SATURATION; WATER

Citation Formats

Koch, Steven J., Thayer, Gayle E., Corwin, Alex D., and Boer, Maarten P. de. Micromachined piconewton force sensor for biophysics investigations. United States: N. p., 2006. Web. doi:10.1063/1.2364118.
Koch, Steven J., Thayer, Gayle E., Corwin, Alex D., & Boer, Maarten P. de. Micromachined piconewton force sensor for biophysics investigations. United States. doi:10.1063/1.2364118.
Koch, Steven J., Thayer, Gayle E., Corwin, Alex D., and Boer, Maarten P. de. Mon . "Micromachined piconewton force sensor for biophysics investigations". United States. doi:10.1063/1.2364118.
@article{osti_20880061,
title = {Micromachined piconewton force sensor for biophysics investigations},
author = {Koch, Steven J. and Thayer, Gayle E. and Corwin, Alex D. and Boer, Maarten P. de},
abstractNote = {We describe a micromachined force sensor that is able to measure forces as small as 1 pN in both air and water. First, we measured the force field produced by an electromagnet on individual 2.8 {mu}m magnetic beads glued to the sensor. By repeating with 11 different beads, we measured a 9% standard deviation in saturation magnetization. We next demonstrated that the sensor was fully functional when immersed in physiological buffer. These results show that the force sensors can be useful for magnetic force calibration and also for measurement of biophysical forces on chip.},
doi = {10.1063/1.2364118},
journal = {Applied Physics Letters},
number = 17,
volume = 89,
place = {United States},
year = {Mon Oct 23 00:00:00 EDT 2006},
month = {Mon Oct 23 00:00:00 EDT 2006}
}