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Title: House dust as possible route of environmental exposure to cadmium and lead in the adult general population

Abstract

Contaminated soil particles and food are established routes of exposure. We investigated the relations between biomarkers of exposure to cadmium and lead, and the metal loading rates in house dust in the adult residents of an area with a soil cadmium concentration of >=3mg/kg (n=268) and a reference area (n=205). We determined the metal concentrations in house dust allowed to settle for 3 months in Petri dishes placed in the participants' bedrooms. The continuously distributed vegetable index was the first principal component derived from the metal concentrations in six different vegetables. The biomarkers of exposure (blood cadmium 9.2 vs. 6.2nmol/L; 24-h urinary cadmium 10.5 vs. 7.0nmol; blood lead 0.31 vs. 0.24{mu}mol/L), the loading rates of cadmium and lead in house dust (0.29 vs. 0.12 and 7.52 vs. 3.62ng/cm{sup 2}/92 days), and the vegetable indexes (0.31 vs. -0.44 and 0.13 vs. -0.29 standardized units) were significantly higher in the contaminated area. A two-fold increase in the metal loading rate in house dust was associated with increases (P<0.001) in blood cadmium (+2.3%), 24-h urinary cadmium (+3.0%), and blood lead (+2.0%), independent of the vegetable index and other covariates. The estimated effect sizes on the biomarkers of internal exposure were three times greatermore » for house dust than vegetables. In conclusion, in the adult population, house dust is potentially an important route of exposure to heavy metals in areas with contaminated soils, and should be incorporated in the assessment of health risks.« less

Authors:
 [1];  [2];  [1];  [2];  [1];  [3];  [4];  [1];  [5]
  1. Centrum voor Milieukunde, Limburgs Universitair Centrum, Diepenbeek (Belgium)
  2. Studiecooerdinatiecentrum, Departement Hart-en Vaatziekten, Katholieke Universiteit Leuven (Belgium)
  3. Onderzoeksgroep voor Sociale en Economische Geografie, Katholieke Universiteit Leuven (Belgium)
  4. Unite de Toxicologie Industrielle et de Medecine du Travail, Universite catholique de Louvain, Bruxelles (Belgium)
  5. Studiecooerdinatiecentrum, Departement Hart-en Vaatziekten, Katholieke Universiteit Leuven (Belgium). E-mail: jan.staessen@med.kuleuven.be
Publication Date:
OSTI Identifier:
20861684
Resource Type:
Journal Article
Resource Relation:
Journal Name: Environmental Research; Journal Volume: 103; Journal Issue: 1; Other Information: DOI: 10.1016/j.envres.2006.05.009; PII: S0013-9351(06)00128-9; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; BIOLOGICAL MARKERS; BLOOD; CADMIUM; DUSTS; ENVIRONMENTAL EXPOSURE; HEAVY METALS; INDOOR AIR POLLUTION; LEAD; SOILS; VEGETABLES

Citation Formats

Hogervorst, Janneke, Plusquin, Michelle, Vangronsveld, Jaco, Nawrot, Tim, Cuypers, Ann, Van Hecke, Etienne, Roels, Harry A., Carleer, Robert, and Staessen, Jan A.. House dust as possible route of environmental exposure to cadmium and lead in the adult general population. United States: N. p., 2007. Web. doi:10.1016/j.envres.2006.05.009.
Hogervorst, Janneke, Plusquin, Michelle, Vangronsveld, Jaco, Nawrot, Tim, Cuypers, Ann, Van Hecke, Etienne, Roels, Harry A., Carleer, Robert, & Staessen, Jan A.. House dust as possible route of environmental exposure to cadmium and lead in the adult general population. United States. doi:10.1016/j.envres.2006.05.009.
Hogervorst, Janneke, Plusquin, Michelle, Vangronsveld, Jaco, Nawrot, Tim, Cuypers, Ann, Van Hecke, Etienne, Roels, Harry A., Carleer, Robert, and Staessen, Jan A.. Mon . "House dust as possible route of environmental exposure to cadmium and lead in the adult general population". United States. doi:10.1016/j.envres.2006.05.009.
@article{osti_20861684,
title = {House dust as possible route of environmental exposure to cadmium and lead in the adult general population},
author = {Hogervorst, Janneke and Plusquin, Michelle and Vangronsveld, Jaco and Nawrot, Tim and Cuypers, Ann and Van Hecke, Etienne and Roels, Harry A. and Carleer, Robert and Staessen, Jan A.},
abstractNote = {Contaminated soil particles and food are established routes of exposure. We investigated the relations between biomarkers of exposure to cadmium and lead, and the metal loading rates in house dust in the adult residents of an area with a soil cadmium concentration of >=3mg/kg (n=268) and a reference area (n=205). We determined the metal concentrations in house dust allowed to settle for 3 months in Petri dishes placed in the participants' bedrooms. The continuously distributed vegetable index was the first principal component derived from the metal concentrations in six different vegetables. The biomarkers of exposure (blood cadmium 9.2 vs. 6.2nmol/L; 24-h urinary cadmium 10.5 vs. 7.0nmol; blood lead 0.31 vs. 0.24{mu}mol/L), the loading rates of cadmium and lead in house dust (0.29 vs. 0.12 and 7.52 vs. 3.62ng/cm{sup 2}/92 days), and the vegetable indexes (0.31 vs. -0.44 and 0.13 vs. -0.29 standardized units) were significantly higher in the contaminated area. A two-fold increase in the metal loading rate in house dust was associated with increases (P<0.001) in blood cadmium (+2.3%), 24-h urinary cadmium (+3.0%), and blood lead (+2.0%), independent of the vegetable index and other covariates. The estimated effect sizes on the biomarkers of internal exposure were three times greater for house dust than vegetables. In conclusion, in the adult population, house dust is potentially an important route of exposure to heavy metals in areas with contaminated soils, and should be incorporated in the assessment of health risks.},
doi = {10.1016/j.envres.2006.05.009},
journal = {Environmental Research},
number = 1,
volume = 103,
place = {United States},
year = {Mon Jan 15 00:00:00 EST 2007},
month = {Mon Jan 15 00:00:00 EST 2007}
}