Adventitial fibroblasts are activated in the early stages of atherosclerosis in the apolipoprotein E knockout mouse
- Department of Pathophysiology, School of Medicine, Shandong University, Jinan 250012, Shandong (China)
The role of the adventitia in vascular function and vascular lesion formation has been largely ignored. This study observed the activation of the adventitia and specifically the fibroblasts in the development of atherosclerosis in the apoE(-/-) mouse. The results showed a gradual increase in expression of collagen types I and III after 2, 4, and 8 weeks of hyperlipidic diet. The earliest expression of monocyte chemoattractant protein-1 (MCP-1) protein and mRNA was detected in the adventitial fibroblast before the formation of intimal lesions. Proliferation, too, was first found in the adventitial fibroblasts. We hypothesize that the adventitial fibroblast is activated in the early stage of atherosclerosis. Adventitial inflammation may be an early event in the development of atherosclerotic lesions.
- OSTI ID:
- 20857965
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 352, Issue 3; Other Information: DOI: 10.1016/j.bbrc.2006.11.073; PII: S0006-291X(06)02552-6; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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