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Title: Adventitial fibroblasts are activated in the early stages of atherosclerosis in the apolipoprotein E knockout mouse

Abstract

The role of the adventitia in vascular function and vascular lesion formation has been largely ignored. This study observed the activation of the adventitia and specifically the fibroblasts in the development of atherosclerosis in the apoE(-/-) mouse. The results showed a gradual increase in expression of collagen types I and III after 2, 4, and 8 weeks of hyperlipidic diet. The earliest expression of monocyte chemoattractant protein-1 (MCP-1) protein and mRNA was detected in the adventitial fibroblast before the formation of intimal lesions. Proliferation, too, was first found in the adventitial fibroblasts. We hypothesize that the adventitial fibroblast is activated in the early stage of atherosclerosis. Adventitial inflammation may be an early event in the development of atherosclerotic lesions.

Authors:
 [1];  [1];  [1];  [1];  [2]
  1. Department of Pathophysiology, School of Medicine, Shandong University, Jinan 250012, Shandong (China)
  2. Department of Pathophysiology, School of Medicine, Shandong University, Jinan 250012, Shandong (China). E-mail: huweicheng@sdu.edu.cn
Publication Date:
OSTI Identifier:
20857965
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 352; Journal Issue: 3; Other Information: DOI: 10.1016/j.bbrc.2006.11.073; PII: S0006-291X(06)02552-6; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ARTERIOSCLEROSIS; COLLAGEN; DIET; FIBROBLASTS; INFLAMMATION; KNOCK-OUT REACTIONS; MICE; MONOCYTES

Citation Formats

Xu Fang, Ji Jian, Li Li, Chen Rong, and Hu Weicheng. Adventitial fibroblasts are activated in the early stages of atherosclerosis in the apolipoprotein E knockout mouse. United States: N. p., 2007. Web.
Xu Fang, Ji Jian, Li Li, Chen Rong, & Hu Weicheng. Adventitial fibroblasts are activated in the early stages of atherosclerosis in the apolipoprotein E knockout mouse. United States.
Xu Fang, Ji Jian, Li Li, Chen Rong, and Hu Weicheng. Fri . "Adventitial fibroblasts are activated in the early stages of atherosclerosis in the apolipoprotein E knockout mouse". United States. doi:.
@article{osti_20857965,
title = {Adventitial fibroblasts are activated in the early stages of atherosclerosis in the apolipoprotein E knockout mouse},
author = {Xu Fang and Ji Jian and Li Li and Chen Rong and Hu Weicheng},
abstractNote = {The role of the adventitia in vascular function and vascular lesion formation has been largely ignored. This study observed the activation of the adventitia and specifically the fibroblasts in the development of atherosclerosis in the apoE(-/-) mouse. The results showed a gradual increase in expression of collagen types I and III after 2, 4, and 8 weeks of hyperlipidic diet. The earliest expression of monocyte chemoattractant protein-1 (MCP-1) protein and mRNA was detected in the adventitial fibroblast before the formation of intimal lesions. Proliferation, too, was first found in the adventitial fibroblasts. We hypothesize that the adventitial fibroblast is activated in the early stage of atherosclerosis. Adventitial inflammation may be an early event in the development of atherosclerotic lesions.},
doi = {},
journal = {Biochemical and Biophysical Research Communications},
number = 3,
volume = 352,
place = {United States},
year = {Fri Jan 19 00:00:00 EST 2007},
month = {Fri Jan 19 00:00:00 EST 2007}
}