Decreased expression of thyroid receptor-associated protein 220 in temporal lobe tissue of patients with refractory epilepsy

Journal Article · Fri Oct 06 00:00:00 EDT 2006 · Biochemical and Biophysical Research Communications

OSTI ID:20854505

Jinmei, Li ^[1]; Xuefeng, Wang ^[1]; Zhiqin, Xi ^[1]; Yun, Gong ^[1]; Fengying, Liu ^[1]; Jijun, Sun ^[1]; Yuan, Wu ^[1]; Guoming, Luan ^[2]; Yuping, Wang ^[3]; Yunlin, Li ^[3]; Jianguo, Zhang ^[2]; Yong, Lu ^[4]; Hongwei, Li ^[4]

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1. Neurology Department, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 4000162 (China)
2. Beijing Tiantan Hospital of the Capital University of Medical Sciences, 6th Xili Road, Tiantan, Chongwen District, Beijing 100050 (China)
3. Beijing Xuanwu Hospital the Capital University of Medical Sciences, 45th Changchun Road, Xuanwu District, Beijing 100053 (China)
4. Criminal Science Institute of Chongqing, 101st Changjiang 2nd Road, Daping, Yuzhong District, Chongqing 400042 (China)

Purpose: TRAP220 (thyroid hormone receptor-associated protein) functions as a coactivator for nuclear receptors and stimulates transcription by recruiting the TRAP mediator complex to hormone responsive promoter regions. Thus, TRAP220 enhances the function of thyroid/steroid hormone receptors such as thyroid hormone and oestrogen receptors. This study investigated the expression of TRAP220 mRNA and protein level in epileptic brains comparing with human control. Methods: We examined the expression of TRAP220 mRNA and protein levels in temporal lobes from patients with chronic pharmacoresistant epilepsy who have undergone surgery. Results: Expression of TRAP220 mRNA and protein was shown to be decreased significantly in the temporal cortex of the patients with epilepsy. Conclusions: Our work showed that a decrease in TRAP220 mRNA and protein levels may be involved in the pathophysiology of epilepsy and may be associated with impairment of the brain caused by frequent seizures.

• OSTI ID: 20854505
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 348, Issue 4; Other Information: DOI: 10.1016/j.bbrc.2006.08.010; PII: S0006-291X(06)01780-3; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BRAIN
EPILEPSY
PATIENTS
PROMOTERS
RECEPTORS
STEROID HORMONES
SURGERY
THYROID
THYROID HORMONES
TRANSCRIPTION