Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells
- Service de Biochimie et Biologie Moleculaire, UPRES-EA 2493, Faculte de Medecine Paris-Ile de France Ouest, Universite Versailles-St Quentin, Centre Hospitalier de Poissy, 78303 Poissy Cedex (France)
It is well established that obesity is a risk factor for breast cancer and that blood levels of adiponectin, a hormone mainly secreted by white adipocytes, are inversely correlated with the body fat mass. As adiponectin elicits anti-proliferative effects in some cell types, we tested the hypothesis that adiponectin could influence human breast cancer MCF-7 cell growth. Here we show that MCF-7 cells express adiponectin receptors and respond to human recombinant adiponectin by reducing their growth, AMPkinase activation, and p42/p44 MAPkinase inactivation. Further, we demonstrate that the anti-proliferative effect of adiponectin involves activation of cell apoptosis and inhibition of cell cycle. These findings suggest that adiponectin could act in vivo as a paracrine/endocrine growth inhibitor towards mammary epithelial cells. Moreover, adipose adiponectin production being strongly reduced in obesity, this study may help to explain why obesity is a risk factor of developing breast cancers.
- OSTI ID:
- 20854316
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 345, Issue 1; Other Information: DOI: 10.1016/j.bbrc.2006.04.076; PII: S0006-291X(06)00919-3; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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