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Title: Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics

Abstract

One of the major medical applications of optoacoustic (OA) tomography is in the diagnostics of early-stage breast cancer. A numerical approach was developed to characterize the following parameters of an OA imaging system: resolution, maximum depth at which the tumor can be detected, and image contrast. The parameters of the 64-element focused array transducer were obtained. The results of numerical modeling were compared with known analytical solutions and further validated by phantom experiments. The OA images of a3 mm piece of bovine liver immersed in diluted milk at various depths were obtained. Based on the results of modeling, a signal filtering algorithm for OA image contrast enhancement has been proposed.

Authors:
; ; ; ; ;
Publication Date:
OSTI Identifier:
20854009
Resource Type:
Journal Article
Resource Relation:
Journal Name: Applied Optics; Journal Volume: 46; Journal Issue: 2; Other Information: DOI: 10.1364/AO.46.000262; (c) 2007 Optical Society of America; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; ALGORITHMS; ANALYTICAL SOLUTION; BIOMEDICAL RADIOGRAPHY; CATTLE; IMAGES; LIVER; MAMMARY GLANDS; MILK; NEOPLASMS; PHANTOMS; PHOTOACOUSTIC EFFECT; RESOLUTION; SENSITIVITY; SIGNALS; SIMULATION; TOMOGRAPHY; TRANSDUCERS

Citation Formats

Khokhlova, Tatiana D., Pelivanov, Ivan M., Kozhushko, Victor V., Zharinov, Alexei N., Solomatin, Vladimir S., and Karabutov, Alexander A. Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics. United States: N. p., 2007. Web. doi:10.1364/AO.46.000262.
Khokhlova, Tatiana D., Pelivanov, Ivan M., Kozhushko, Victor V., Zharinov, Alexei N., Solomatin, Vladimir S., & Karabutov, Alexander A. Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics. United States. doi:10.1364/AO.46.000262.
Khokhlova, Tatiana D., Pelivanov, Ivan M., Kozhushko, Victor V., Zharinov, Alexei N., Solomatin, Vladimir S., and Karabutov, Alexander A. Wed . "Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics". United States. doi:10.1364/AO.46.000262.
@article{osti_20854009,
title = {Optoacoustic imaging of absorbing objects in a turbid medium: ultimate sensitivity and application to breast cancer diagnostics},
author = {Khokhlova, Tatiana D. and Pelivanov, Ivan M. and Kozhushko, Victor V. and Zharinov, Alexei N. and Solomatin, Vladimir S. and Karabutov, Alexander A},
abstractNote = {One of the major medical applications of optoacoustic (OA) tomography is in the diagnostics of early-stage breast cancer. A numerical approach was developed to characterize the following parameters of an OA imaging system: resolution, maximum depth at which the tumor can be detected, and image contrast. The parameters of the 64-element focused array transducer were obtained. The results of numerical modeling were compared with known analytical solutions and further validated by phantom experiments. The OA images of a3 mm piece of bovine liver immersed in diluted milk at various depths were obtained. Based on the results of modeling, a signal filtering algorithm for OA image contrast enhancement has been proposed.},
doi = {10.1364/AO.46.000262},
journal = {Applied Optics},
number = 2,
volume = 46,
place = {United States},
year = {Wed Jan 10 00:00:00 EST 2007},
month = {Wed Jan 10 00:00:00 EST 2007}
}