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Title: Dose contributions from large-angle scattered particles in therapeutic carbon beams

Abstract

In carbon therapy, doses at center of spread-out Bragg peaks depend on field size. For a small field of 5x5 cm{sup 2}, the central dose reduces to 96% of the central dose for the open field in case of 400 MeV/n carbon beam. Assuming the broad beam injected to the water phantom is made up of many pencil beams, the transverse dose distribution can be reconstructed by summing the dose distribution of the pencil beams. We estimated dose profiles of this pencil beam through measurements of dose distributions of broad uniform beams blocked half of the irradiation fields. The dose at a distance of a few cm from the edge of the irradiation field reaches up to a few percent of the central dose. From radiation quality measurements of this penumbra, the large-angle scattered particles were found to be secondary fragments which have lower LET than primary carbon beams. Carbon ions break up in beam modifying devices or in water phantom through nuclear interaction with target nuclei. The angular distributions of these fragmented nuclei are much broader than those of primary carbon particles. The transverse dose distribution of the pencil beam can be approximated by a function of the three-Gaussianmore » form. For a simplest case of mono-energetic beam, contributions of the Gaussian components which have large mean deviations become larger as the depth in the water phantom increases.« less

Authors:
; ; ; ; ; ; ;  [1];  [2];  [2];  [2];  [2]
  1. Tokai University Unified Graduate School, Graduate School of Science and Technology, 1117 Kitakaname, Hiratsuka, Kanagawa, 259-1292, Japan and Accelerator Engineering Co., 2-13-1 Konakadai, Inage-ku, Chiba 263-0043 (Japan)
  2. (Japan)
Publication Date:
OSTI Identifier:
20853909
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 34; Journal Issue: 1; Other Information: DOI: 10.1118/1.2402328; (c) 2007 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ANGULAR DISTRIBUTION; BEAMS; BRAGG CURVE; CARBON IONS; DOSIMETRY; GAUSS FUNCTION; IRRADIATION; LET; PHANTOMS; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; RADIATION QUALITY; RADIOTHERAPY

Citation Formats

Kusano, Yohsuke, Kanai, Tatsuaki, Kase, Yuki, Matsufuji, Naruhiro, Komori, Masataka, Kanematsu, Nobuyuki, Ito, Atsushi, Uchida, Hirohisa, Department of Accelerator and Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan, and Tokyo Institute of Technology, Interdisciplinary Graduate School of Science and Engineering, 4259 Nagatsuta-cho, Midori-ku, Yokohama-shi, Kanagawa 226-8503, Tokyo Institute of Technology, Interdisciplinary Graduate School of Science and Engineering, 4259 Nagatsuta-cho, Midori-ku, Yokohama-shi, Kanagawa 226-8503, Department of Accelerator and Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, and Department of Energy Science and Engineering, School of Engineering, Tokai University, 1117 Kitakaname, Hiratsuka, Kanagawa 259-1292. Dose contributions from large-angle scattered particles in therapeutic carbon beams. United States: N. p., 2007. Web. doi:10.1118/1.2402328.
Kusano, Yohsuke, Kanai, Tatsuaki, Kase, Yuki, Matsufuji, Naruhiro, Komori, Masataka, Kanematsu, Nobuyuki, Ito, Atsushi, Uchida, Hirohisa, Department of Accelerator and Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan, and Tokyo Institute of Technology, Interdisciplinary Graduate School of Science and Engineering, 4259 Nagatsuta-cho, Midori-ku, Yokohama-shi, Kanagawa 226-8503, Tokyo Institute of Technology, Interdisciplinary Graduate School of Science and Engineering, 4259 Nagatsuta-cho, Midori-ku, Yokohama-shi, Kanagawa 226-8503, Department of Accelerator and Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, & Department of Energy Science and Engineering, School of Engineering, Tokai University, 1117 Kitakaname, Hiratsuka, Kanagawa 259-1292. Dose contributions from large-angle scattered particles in therapeutic carbon beams. United States. doi:10.1118/1.2402328.
Kusano, Yohsuke, Kanai, Tatsuaki, Kase, Yuki, Matsufuji, Naruhiro, Komori, Masataka, Kanematsu, Nobuyuki, Ito, Atsushi, Uchida, Hirohisa, Department of Accelerator and Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan, and Tokyo Institute of Technology, Interdisciplinary Graduate School of Science and Engineering, 4259 Nagatsuta-cho, Midori-ku, Yokohama-shi, Kanagawa 226-8503, Tokyo Institute of Technology, Interdisciplinary Graduate School of Science and Engineering, 4259 Nagatsuta-cho, Midori-ku, Yokohama-shi, Kanagawa 226-8503, Department of Accelerator and Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, and Department of Energy Science and Engineering, School of Engineering, Tokai University, 1117 Kitakaname, Hiratsuka, Kanagawa 259-1292. Mon . "Dose contributions from large-angle scattered particles in therapeutic carbon beams". United States. doi:10.1118/1.2402328.
@article{osti_20853909,
title = {Dose contributions from large-angle scattered particles in therapeutic carbon beams},
author = {Kusano, Yohsuke and Kanai, Tatsuaki and Kase, Yuki and Matsufuji, Naruhiro and Komori, Masataka and Kanematsu, Nobuyuki and Ito, Atsushi and Uchida, Hirohisa and Department of Accelerator and Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan, and Tokyo Institute of Technology, Interdisciplinary Graduate School of Science and Engineering, 4259 Nagatsuta-cho, Midori-ku, Yokohama-shi, Kanagawa 226-8503 and Tokyo Institute of Technology, Interdisciplinary Graduate School of Science and Engineering, 4259 Nagatsuta-cho, Midori-ku, Yokohama-shi, Kanagawa 226-8503 and Department of Accelerator and Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 and Department of Energy Science and Engineering, School of Engineering, Tokai University, 1117 Kitakaname, Hiratsuka, Kanagawa 259-1292},
abstractNote = {In carbon therapy, doses at center of spread-out Bragg peaks depend on field size. For a small field of 5x5 cm{sup 2}, the central dose reduces to 96% of the central dose for the open field in case of 400 MeV/n carbon beam. Assuming the broad beam injected to the water phantom is made up of many pencil beams, the transverse dose distribution can be reconstructed by summing the dose distribution of the pencil beams. We estimated dose profiles of this pencil beam through measurements of dose distributions of broad uniform beams blocked half of the irradiation fields. The dose at a distance of a few cm from the edge of the irradiation field reaches up to a few percent of the central dose. From radiation quality measurements of this penumbra, the large-angle scattered particles were found to be secondary fragments which have lower LET than primary carbon beams. Carbon ions break up in beam modifying devices or in water phantom through nuclear interaction with target nuclei. The angular distributions of these fragmented nuclei are much broader than those of primary carbon particles. The transverse dose distribution of the pencil beam can be approximated by a function of the three-Gaussian form. For a simplest case of mono-energetic beam, contributions of the Gaussian components which have large mean deviations become larger as the depth in the water phantom increases.},
doi = {10.1118/1.2402328},
journal = {Medical Physics},
number = 1,
volume = 34,
place = {United States},
year = {Mon Jan 15 00:00:00 EST 2007},
month = {Mon Jan 15 00:00:00 EST 2007}
}