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Title: Dose point kernel for boron-11 decay and the cellular S values in boron neutron capture therapy

Abstract

The study of the radiobiology of boron neutron capture therapy is based on the cellular level dosimetry of boron-10's thermal neutron capture reaction {sup 10}B(n,{alpha}){sup 7}Li, in which one 1.47 MeV helium-4 ion and one 0.84 MeV lithium-7 ion are spawned. Because of the chemical preference of boron-10 carrier molecules, the dose is heterogeneously distributed in cells. In the present work, the (scaled) dose point kernel of boron-11 decay, called {sup 11}B-DPK, was calculated by GEANT4 Monte Carlo simulation code. The DPK curve drops suddenly at the radius of 4.26 {mu}m, the continuous slowing down approximation (CSDA) range of a lithium-7 ion. Then, after a slight ascending, the curve decreases to near zero when the radius goes beyond 8.20 {mu}m, which is the CSDA range of a 1.47 MeV helium-4 ion. With the DPK data, S values for nuclei and cells with the boron-10 on the cell surface are calculated for different combinations of cell and nucleus sizes. The S value for a cell radius of 10 {mu}m and a nucleus radius of 5 {mu}m is slightly larger than the value published by Tung et al. [Appl. Radiat. Isot. 61, 739-743 (2004)]. This result is potentially more accurate than themore » published value since it includes the contribution of a lithium-7 ion as well as the alpha particle.« less

Authors:
; ; ;  [1];  [2];  [2]
  1. Research Center for Tumor Diagnosis and Radiotherapy Physics and Laboratory of Medical Physics and Engineering, Peking University, Beijing 100871 (China)
  2. (China)
Publication Date:
OSTI Identifier:
20853840
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 33; Journal Issue: 12; Other Information: DOI: 10.1118/1.2358849; (c) 2006 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; APPROXIMATIONS; BIOPHYSICS; BORON 10; BORON 11; COMPUTERIZED SIMULATION; HELIUM 4; LITHIUM 7; MICRODOSIMETRY; MONTE CARLO METHOD; NEUTRON CAPTURE THERAPY; POINT KERNELS; RADIATION DOSES; RADIOBIOLOGY; THERMAL NEUTRONS

Citation Formats

Ma Yunzhi, Geng Jinpeng, Gao Song, Bao Shanglian, Department of Nuclear Physics, Chinese Institute of Atomic Energy, Beijing, 102413, and Research Center for Tumor Diagnosis and Radiotherapy Physics and Laboratory of Medical Physics and Engineering, Peking University, Beijing 100871. Dose point kernel for boron-11 decay and the cellular S values in boron neutron capture therapy. United States: N. p., 2006. Web. doi:10.1118/1.2358849.
Ma Yunzhi, Geng Jinpeng, Gao Song, Bao Shanglian, Department of Nuclear Physics, Chinese Institute of Atomic Energy, Beijing, 102413, & Research Center for Tumor Diagnosis and Radiotherapy Physics and Laboratory of Medical Physics and Engineering, Peking University, Beijing 100871. Dose point kernel for boron-11 decay and the cellular S values in boron neutron capture therapy. United States. doi:10.1118/1.2358849.
Ma Yunzhi, Geng Jinpeng, Gao Song, Bao Shanglian, Department of Nuclear Physics, Chinese Institute of Atomic Energy, Beijing, 102413, and Research Center for Tumor Diagnosis and Radiotherapy Physics and Laboratory of Medical Physics and Engineering, Peking University, Beijing 100871. Fri . "Dose point kernel for boron-11 decay and the cellular S values in boron neutron capture therapy". United States. doi:10.1118/1.2358849.
@article{osti_20853840,
title = {Dose point kernel for boron-11 decay and the cellular S values in boron neutron capture therapy},
author = {Ma Yunzhi and Geng Jinpeng and Gao Song and Bao Shanglian and Department of Nuclear Physics, Chinese Institute of Atomic Energy, Beijing, 102413 and Research Center for Tumor Diagnosis and Radiotherapy Physics and Laboratory of Medical Physics and Engineering, Peking University, Beijing 100871},
abstractNote = {The study of the radiobiology of boron neutron capture therapy is based on the cellular level dosimetry of boron-10's thermal neutron capture reaction {sup 10}B(n,{alpha}){sup 7}Li, in which one 1.47 MeV helium-4 ion and one 0.84 MeV lithium-7 ion are spawned. Because of the chemical preference of boron-10 carrier molecules, the dose is heterogeneously distributed in cells. In the present work, the (scaled) dose point kernel of boron-11 decay, called {sup 11}B-DPK, was calculated by GEANT4 Monte Carlo simulation code. The DPK curve drops suddenly at the radius of 4.26 {mu}m, the continuous slowing down approximation (CSDA) range of a lithium-7 ion. Then, after a slight ascending, the curve decreases to near zero when the radius goes beyond 8.20 {mu}m, which is the CSDA range of a 1.47 MeV helium-4 ion. With the DPK data, S values for nuclei and cells with the boron-10 on the cell surface are calculated for different combinations of cell and nucleus sizes. The S value for a cell radius of 10 {mu}m and a nucleus radius of 5 {mu}m is slightly larger than the value published by Tung et al. [Appl. Radiat. Isot. 61, 739-743 (2004)]. This result is potentially more accurate than the published value since it includes the contribution of a lithium-7 ion as well as the alpha particle.},
doi = {10.1118/1.2358849},
journal = {Medical Physics},
number = 12,
volume = 33,
place = {United States},
year = {Fri Dec 15 00:00:00 EST 2006},
month = {Fri Dec 15 00:00:00 EST 2006}
}