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Title: Dosimetric characterization of a novel intracavitary mold applicator for {sup 192}Ir high dose rate endorectal brachytherapy treatment

Abstract

The dosimetric properties of a novel intracavitary mold applicator for {sup 192}Ir high dose rate (HDR) endorectal cancer treatment have been investigated using Monte Carlo (MC) simulations and experimental methods. The 28 cm long applicator has a flexible structure made of silicone rubber for easy passage into cavities with deep-seated tumors. It consists of eight source catheters arranged around a central cavity for shielding insertion, and is compatible for use with an endocavitary balloon. A phase space model of the HDR source has been validated for dose calculations using the GEANT4 MC code. GAFCHROMIC trade mark sign EBT model film was used to measure dose distributions in water around shielded and unshielded applicators with two loading configurations, and to quantify the shielding effect of a balloon injected with an iodine solution (300 mg I/mL). The film calibration procedure was performed in water using an {sup 192}Ir HDR source. Ionization chamber measurements in a Lucite phantom show that placing a tungsten rod in the applicator attenuates the dose in the shielded region by up to 85%. Inserting the shielded applicator into a water-filled balloon pushes the neighboring tissues away from the radiation source, and the resulting geometric displacement reduces the dosemore » by up to 53%; another 8% dose reduction can be achieved when the balloon is injected with an iodine solution. All experimental results agree with the GEANT4 calculations within measurement uncertainties.« less

Authors:
; ; ; ;  [1];  [2];  [2]
  1. Medical Physics Unit, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4 (Canada)
  2. (Canada)
Publication Date:
OSTI Identifier:
20853819
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical Physics; Journal Volume: 33; Journal Issue: 12; Other Information: DOI: 10.1118/1.2364054; (c) 2006 American Association of Physicists in Medicine; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRACHYTHERAPY; DOSE RATES; FUNGI; IODINE; IONIZATION CHAMBERS; IRIDIUM 192; LUCITE; MONTE CARLO METHOD; NEOPLASMS; PHANTOMS; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; RADIATION SOURCES; RODS; SILICONES; TUNGSTEN

Citation Formats

Poon, Emily, Reniers, Brigitte, Devic, Slobodan, Vuong, Te, Verhaegen, Frank, Department of Radiation Oncology, McGill University Health Center, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, and Medical Physics Unit, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4. Dosimetric characterization of a novel intracavitary mold applicator for {sup 192}Ir high dose rate endorectal brachytherapy treatment. United States: N. p., 2006. Web. doi:10.1118/1.2364054.
Poon, Emily, Reniers, Brigitte, Devic, Slobodan, Vuong, Te, Verhaegen, Frank, Department of Radiation Oncology, McGill University Health Center, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, & Medical Physics Unit, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4. Dosimetric characterization of a novel intracavitary mold applicator for {sup 192}Ir high dose rate endorectal brachytherapy treatment. United States. doi:10.1118/1.2364054.
Poon, Emily, Reniers, Brigitte, Devic, Slobodan, Vuong, Te, Verhaegen, Frank, Department of Radiation Oncology, McGill University Health Center, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, and Medical Physics Unit, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4. Fri . "Dosimetric characterization of a novel intracavitary mold applicator for {sup 192}Ir high dose rate endorectal brachytherapy treatment". United States. doi:10.1118/1.2364054.
@article{osti_20853819,
title = {Dosimetric characterization of a novel intracavitary mold applicator for {sup 192}Ir high dose rate endorectal brachytherapy treatment},
author = {Poon, Emily and Reniers, Brigitte and Devic, Slobodan and Vuong, Te and Verhaegen, Frank and Department of Radiation Oncology, McGill University Health Center, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4 and Medical Physics Unit, McGill University, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4},
abstractNote = {The dosimetric properties of a novel intracavitary mold applicator for {sup 192}Ir high dose rate (HDR) endorectal cancer treatment have been investigated using Monte Carlo (MC) simulations and experimental methods. The 28 cm long applicator has a flexible structure made of silicone rubber for easy passage into cavities with deep-seated tumors. It consists of eight source catheters arranged around a central cavity for shielding insertion, and is compatible for use with an endocavitary balloon. A phase space model of the HDR source has been validated for dose calculations using the GEANT4 MC code. GAFCHROMIC trade mark sign EBT model film was used to measure dose distributions in water around shielded and unshielded applicators with two loading configurations, and to quantify the shielding effect of a balloon injected with an iodine solution (300 mg I/mL). The film calibration procedure was performed in water using an {sup 192}Ir HDR source. Ionization chamber measurements in a Lucite phantom show that placing a tungsten rod in the applicator attenuates the dose in the shielded region by up to 85%. Inserting the shielded applicator into a water-filled balloon pushes the neighboring tissues away from the radiation source, and the resulting geometric displacement reduces the dose by up to 53%; another 8% dose reduction can be achieved when the balloon is injected with an iodine solution. All experimental results agree with the GEANT4 calculations within measurement uncertainties.},
doi = {10.1118/1.2364054},
journal = {Medical Physics},
number = 12,
volume = 33,
place = {United States},
year = {Fri Dec 15 00:00:00 EST 2006},
month = {Fri Dec 15 00:00:00 EST 2006}
}