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Title: Decreased number of CD4{sup +} and CD8{sup +} T cells that express the interleukin-7 receptor in blood and tissues of SIV-infected macaques

Abstract

Acute HIV/SIV (human/simian immunodeficiency virus) infection results in severe CD4{sup +} T cell depletion in lymphoid compartments. During the chronic phase of infection, CD4{sup +} T cell numbers rebound in blood but remain low in the gut-associated lymphoid tissue (GALT), even when viral replication is suppressed by antiretroviral therapy (ART). Thus, strategies to repopulate lymphoid compartments may ameliorate the clinical outcome of HIV/SIV infection. Interleukin (IL)-7 is a key cytokine for the maintenance of homeostatic proliferation of T cells. In HIV/SIV infection, IL-7 expression is increased, likely to compensate for T cell loss, suggesting that supraphysiological administration of IL-7 could provide additional benefit. However, the ability of T cells to respond to IL-7 is dependent on the level of expression of the IL-7 receptor (IL-7R) in T cells in various body compartments. In here, we investigated the proportion of IL-7R{sup +} T cells in blood, spleen, gut, and genitourinary tract of healthy and SIV-infected macaques with various degrees of CD4{sup +} T cell depletion. We found that the percentage of T cells expressing IL-7R was significantly lower in both CD4{sup +} and CD8{sup +} T cell subsets in SIV-infected macaques than in healthy animals and this decrease directly correlated withmore » the CD4{sup +} T cell number. Importantly, the proportion of CD4{sup +} and CD8{sup +} T cells expressing IL-7R in blood paralleled that found in tissues. IL-7R{sup +} T cells within the SIV-specific CD8{sup +} T cells varied and were lowest in most tissues of viremic macaques, likely reflecting continuous antigen stimulation of effector cells.« less

Authors:
 [1];  [2];  [1];  [3];  [1];  [1];  [1];  [2];  [1];  [4]
  1. Animal Models and Retroviral Vaccines Section, National Cancer Institute, NCI, 41/D804, Bethesda, MD 20892-5065 (United States)
  2. (Poland)
  3. Biostatistics and Data Management Section, National Cancer Institute, Bethesda, MD 20892 (United States)
  4. Animal Models and Retroviral Vaccines Section, National Cancer Institute, NCI, 41/D804, Bethesda, MD 20892-5065 (United States). E-mail: franchig@mail.nih.gov
Publication Date:
OSTI Identifier:
20850583
Resource Type:
Journal Article
Resource Relation:
Journal Name: Virology; Journal Volume: 356; Journal Issue: 1-2; Other Information: DOI: 10.1016/j.virol.2006.07.031; PII: S0042-6822(06)00508-3; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; AIDS VIRUS; ANIMALS; ANTIGENS; BLOOD; CELL PROLIFERATION; RECEPTORS; SPLEEN; STIMULATION; THERAPY

Citation Formats

Moniuszko, Marcin, Medical University of Bialystok, Bialystok, Edghill-Smith, Yvette, Venzon, David, Stevceva, Liljana, Nacsa, Janos, Tryniszewska, Elzbieta, Medical University of Bialystok, Bialystok, Tsai, Wen-Po, and Franchini, Genoveffa. Decreased number of CD4{sup +} and CD8{sup +} T cells that express the interleukin-7 receptor in blood and tissues of SIV-infected macaques. United States: N. p., 2006. Web. doi:10.1016/j.virol.2006.07.031.
Moniuszko, Marcin, Medical University of Bialystok, Bialystok, Edghill-Smith, Yvette, Venzon, David, Stevceva, Liljana, Nacsa, Janos, Tryniszewska, Elzbieta, Medical University of Bialystok, Bialystok, Tsai, Wen-Po, & Franchini, Genoveffa. Decreased number of CD4{sup +} and CD8{sup +} T cells that express the interleukin-7 receptor in blood and tissues of SIV-infected macaques. United States. doi:10.1016/j.virol.2006.07.031.
Moniuszko, Marcin, Medical University of Bialystok, Bialystok, Edghill-Smith, Yvette, Venzon, David, Stevceva, Liljana, Nacsa, Janos, Tryniszewska, Elzbieta, Medical University of Bialystok, Bialystok, Tsai, Wen-Po, and Franchini, Genoveffa. Wed . "Decreased number of CD4{sup +} and CD8{sup +} T cells that express the interleukin-7 receptor in blood and tissues of SIV-infected macaques". United States. doi:10.1016/j.virol.2006.07.031.
@article{osti_20850583,
title = {Decreased number of CD4{sup +} and CD8{sup +} T cells that express the interleukin-7 receptor in blood and tissues of SIV-infected macaques},
author = {Moniuszko, Marcin and Medical University of Bialystok, Bialystok and Edghill-Smith, Yvette and Venzon, David and Stevceva, Liljana and Nacsa, Janos and Tryniszewska, Elzbieta and Medical University of Bialystok, Bialystok and Tsai, Wen-Po and Franchini, Genoveffa},
abstractNote = {Acute HIV/SIV (human/simian immunodeficiency virus) infection results in severe CD4{sup +} T cell depletion in lymphoid compartments. During the chronic phase of infection, CD4{sup +} T cell numbers rebound in blood but remain low in the gut-associated lymphoid tissue (GALT), even when viral replication is suppressed by antiretroviral therapy (ART). Thus, strategies to repopulate lymphoid compartments may ameliorate the clinical outcome of HIV/SIV infection. Interleukin (IL)-7 is a key cytokine for the maintenance of homeostatic proliferation of T cells. In HIV/SIV infection, IL-7 expression is increased, likely to compensate for T cell loss, suggesting that supraphysiological administration of IL-7 could provide additional benefit. However, the ability of T cells to respond to IL-7 is dependent on the level of expression of the IL-7 receptor (IL-7R) in T cells in various body compartments. In here, we investigated the proportion of IL-7R{sup +} T cells in blood, spleen, gut, and genitourinary tract of healthy and SIV-infected macaques with various degrees of CD4{sup +} T cell depletion. We found that the percentage of T cells expressing IL-7R was significantly lower in both CD4{sup +} and CD8{sup +} T cell subsets in SIV-infected macaques than in healthy animals and this decrease directly correlated with the CD4{sup +} T cell number. Importantly, the proportion of CD4{sup +} and CD8{sup +} T cells expressing IL-7R in blood paralleled that found in tissues. IL-7R{sup +} T cells within the SIV-specific CD8{sup +} T cells varied and were lowest in most tissues of viremic macaques, likely reflecting continuous antigen stimulation of effector cells.},
doi = {10.1016/j.virol.2006.07.031},
journal = {Virology},
number = 1-2,
volume = 356,
place = {United States},
year = {Wed Dec 20 00:00:00 EST 2006},
month = {Wed Dec 20 00:00:00 EST 2006}
}