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Title: Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development

Abstract

In experimental animals fed standard laboratory diets, penta-BDE mixtures can decrease circulating thyroid hormone and liver vitamin A concentrations. A substantial number of pregnant women and their children have marginal vitamin A status, potentially increasing their risk of adverse effects to penta-BDE exposure. The current study investigated the effects of maternal gestational and lactational penta-BDE exposure on thyroid hormone and vitamin A homeostasis in rats of sufficient vitamin A (VAS) or marginal vitamin A (VAM) status and their offspring. Dams were administered daily oral doses of 18 mg/kg DE-71 (a penta-BDE mixture) or a corn oil vehicle from gestation day 6 through lactation day (LD) 18. Thyroid hormone and vitamin A homeostasis were assessed in plasma and tissues of LD 19 dams and postnatal day (PND) 12, 18, and 31 pups. DE-71 exposure induced hepatomegaly in VAS and VAM pups at all timepoints and increased testes weights at PND 31. While liver vitamin A concentrations were low in DE-71 treated dams and pups, plasma retinol concentrations and plasma retinol binding protein levels were only low in VAM animals exposed to DE-71. DE-71 exposure lowered plasma thyroxine concentrations in VAS and VAM dams and pups. Plasma thyroid stimulating hormone concentrations weremore » high in VAM dams exposed to DE-71, suggesting that marginal vitamin A status enhances the susceptibility to thyroid hormone axis disruption by DE-71. These results support the concept that marginal vitamin A status in pregnant women may increase the risk for PBDE-induced disruptions in vitamin A and thyroid hormone homeostasis.« less

Authors:
 [1];  [1];  [1];  [2]
  1. Department of Nutrition, University of California-Davis, Davis, CA 95616 (United States)
  2. Department of Nutrition, University of California-Davis, Davis, CA 95616 (United States) and Department of Internal Medicine, University of California-Davis, Davis, CA 95616 (United States)
Publication Date:
OSTI Identifier:
20850401
Resource Type:
Journal Article
Journal Name:
Toxicology and Applied Pharmacology
Additional Journal Information:
Journal Volume: 215; Journal Issue: 2; Other Information: DOI: 10.1016/j.taap.2006.02.008; PII: S0041-008X(06)00071-8; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0041-008X
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; CORN OIL; DAMS; DIET; HOMEOSTASIS; LACTATION; LIVER; PHENYL ETHER; PYRAZOLINES; RATS; TESTES; THYROXINE; TSH; VEHICLES; VITAMIN A

Citation Formats

Ellis-Hutchings, Robert G, Department of Environmental Toxicology, University of California-Davis, Davis, CA 95616, Cherr, Gary N, Department of Environmental Toxicology, University of California-Davis, Davis, CA 95616, Bodega Marine Laboratory, University of California-Davis, Bodega Bay, CA 94923, Hanna, Lynn A, and Keen, Carl L. Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development. United States: N. p., 2006. Web. doi:10.1016/j.taap.2006.02.008.
Ellis-Hutchings, Robert G, Department of Environmental Toxicology, University of California-Davis, Davis, CA 95616, Cherr, Gary N, Department of Environmental Toxicology, University of California-Davis, Davis, CA 95616, Bodega Marine Laboratory, University of California-Davis, Bodega Bay, CA 94923, Hanna, Lynn A, & Keen, Carl L. Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development. United States. https://doi.org/10.1016/j.taap.2006.02.008
Ellis-Hutchings, Robert G, Department of Environmental Toxicology, University of California-Davis, Davis, CA 95616, Cherr, Gary N, Department of Environmental Toxicology, University of California-Davis, Davis, CA 95616, Bodega Marine Laboratory, University of California-Davis, Bodega Bay, CA 94923, Hanna, Lynn A, and Keen, Carl L. 2006. "Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development". United States. https://doi.org/10.1016/j.taap.2006.02.008.
@article{osti_20850401,
title = {Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development},
author = {Ellis-Hutchings, Robert G and Department of Environmental Toxicology, University of California-Davis, Davis, CA 95616 and Cherr, Gary N and Department of Environmental Toxicology, University of California-Davis, Davis, CA 95616 and Bodega Marine Laboratory, University of California-Davis, Bodega Bay, CA 94923 and Hanna, Lynn A and Keen, Carl L},
abstractNote = {In experimental animals fed standard laboratory diets, penta-BDE mixtures can decrease circulating thyroid hormone and liver vitamin A concentrations. A substantial number of pregnant women and their children have marginal vitamin A status, potentially increasing their risk of adverse effects to penta-BDE exposure. The current study investigated the effects of maternal gestational and lactational penta-BDE exposure on thyroid hormone and vitamin A homeostasis in rats of sufficient vitamin A (VAS) or marginal vitamin A (VAM) status and their offspring. Dams were administered daily oral doses of 18 mg/kg DE-71 (a penta-BDE mixture) or a corn oil vehicle from gestation day 6 through lactation day (LD) 18. Thyroid hormone and vitamin A homeostasis were assessed in plasma and tissues of LD 19 dams and postnatal day (PND) 12, 18, and 31 pups. DE-71 exposure induced hepatomegaly in VAS and VAM pups at all timepoints and increased testes weights at PND 31. While liver vitamin A concentrations were low in DE-71 treated dams and pups, plasma retinol concentrations and plasma retinol binding protein levels were only low in VAM animals exposed to DE-71. DE-71 exposure lowered plasma thyroxine concentrations in VAS and VAM dams and pups. Plasma thyroid stimulating hormone concentrations were high in VAM dams exposed to DE-71, suggesting that marginal vitamin A status enhances the susceptibility to thyroid hormone axis disruption by DE-71. These results support the concept that marginal vitamin A status in pregnant women may increase the risk for PBDE-induced disruptions in vitamin A and thyroid hormone homeostasis.},
doi = {10.1016/j.taap.2006.02.008},
url = {https://www.osti.gov/biblio/20850401}, journal = {Toxicology and Applied Pharmacology},
issn = {0041-008X},
number = 2,
volume = 215,
place = {United States},
year = {Fri Sep 01 00:00:00 EDT 2006},
month = {Fri Sep 01 00:00:00 EDT 2006}
}