Combination ibandronate and radiotherapy for the treatment of bone metastases: Clinical evaluation and radiologic assessment
Abstract
Purpose: Ibandronate is a single-nitrogen, noncyclic bisphosphonate with proven efficacy for reducing metastatic bone pain. In this study, we assessed the palliative effects of combined ibandronate and radiotherapy. Methods and Materials: Forty-five patients with bone metastases from various solid tumors received external-beam radiotherapy, 30-40 Gy over 3-4.5, weeks combined with 10 cycles of monthly intravenous ibandronate, 6 mg. Results: After combined therapy, mean bone pain scores (graded from 0 to 10) were reduced from 6.3 at baseline to 0.8 after 3 months, with further reductions at later time points (all p < 0.001). Opioid use decreased from 84% of patients at baseline (38/45) to 24% (11/45) at 3 months, with further subsequent reductions (all p < 0.001). Mean performance status and functioning scores also significantly improved. Bone density (assessed by computed tomography scan) increased by 20% vs. baseline at 3 months, 46% at 6 months, and 73% at 10 months (all p < 0.001). Lesion improvement was also demonstrated by magnetic resonance imaging. Treatment was well tolerated with no renal toxicity. Conclusions: In this pilot study, combined radiotherapy and ibandronate provided substantial bone pain relief and increased bone density. Computed tomography-based or magnetic resonance imaging-based evaluations offer objective methods formore »
- Authors:
- Department of Radiotherapy, University of Patras Medical School, Patras (Greece)
- Department of Radiology, University of Patras Medical School, Patras (Greece)
- Laboratory of Public Health, University of Patras Medical School, Patras (Greece)
- Department of Radiotherapy, University of Patras Medical School, Patras (Greece). E-mail: kardim@med.upatras.gr
- Publication Date:
- OSTI Identifier:
- 20850324
- Resource Type:
- Journal Article
- Resource Relation:
- Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 67; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2006.08.022; PII: S0360-3016(06)02755-6; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; COMBINED THERAPY; COMPUTERIZED TOMOGRAPHY; EVALUATION; METASTASES; NEOPLASMS; NMR IMAGING; PAIN; PATIENTS; PERFORMANCE; RADIOTHERAPY; SKELETON; TOXICITY
Citation Formats
Vassiliou, Vassilios, Kalogeropoulou, Christine, Christopoulos, Christos, Solomou, Ekaterini, Leotsinides, Michael, and Kardamakis, Dimitrios. Combination ibandronate and radiotherapy for the treatment of bone metastases: Clinical evaluation and radiologic assessment. United States: N. p., 2007.
Web. doi:10.1016/j.ijrobp.2006.08.022.
Vassiliou, Vassilios, Kalogeropoulou, Christine, Christopoulos, Christos, Solomou, Ekaterini, Leotsinides, Michael, & Kardamakis, Dimitrios. Combination ibandronate and radiotherapy for the treatment of bone metastases: Clinical evaluation and radiologic assessment. United States. doi:10.1016/j.ijrobp.2006.08.022.
Vassiliou, Vassilios, Kalogeropoulou, Christine, Christopoulos, Christos, Solomou, Ekaterini, Leotsinides, Michael, and Kardamakis, Dimitrios. Mon .
"Combination ibandronate and radiotherapy for the treatment of bone metastases: Clinical evaluation and radiologic assessment". United States.
doi:10.1016/j.ijrobp.2006.08.022.
@article{osti_20850324,
title = {Combination ibandronate and radiotherapy for the treatment of bone metastases: Clinical evaluation and radiologic assessment},
author = {Vassiliou, Vassilios and Kalogeropoulou, Christine and Christopoulos, Christos and Solomou, Ekaterini and Leotsinides, Michael and Kardamakis, Dimitrios},
abstractNote = {Purpose: Ibandronate is a single-nitrogen, noncyclic bisphosphonate with proven efficacy for reducing metastatic bone pain. In this study, we assessed the palliative effects of combined ibandronate and radiotherapy. Methods and Materials: Forty-five patients with bone metastases from various solid tumors received external-beam radiotherapy, 30-40 Gy over 3-4.5, weeks combined with 10 cycles of monthly intravenous ibandronate, 6 mg. Results: After combined therapy, mean bone pain scores (graded from 0 to 10) were reduced from 6.3 at baseline to 0.8 after 3 months, with further reductions at later time points (all p < 0.001). Opioid use decreased from 84% of patients at baseline (38/45) to 24% (11/45) at 3 months, with further subsequent reductions (all p < 0.001). Mean performance status and functioning scores also significantly improved. Bone density (assessed by computed tomography scan) increased by 20% vs. baseline at 3 months, 46% at 6 months, and 73% at 10 months (all p < 0.001). Lesion improvement was also demonstrated by magnetic resonance imaging. Treatment was well tolerated with no renal toxicity. Conclusions: In this pilot study, combined radiotherapy and ibandronate provided substantial bone pain relief and increased bone density. Computed tomography-based or magnetic resonance imaging-based evaluations offer objective methods for assessing therapeutic outcomes.},
doi = {10.1016/j.ijrobp.2006.08.022},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 1,
volume = 67,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}
-
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Clinical relevance of radiologic examination of the skeleton and bone density measurements in osteoporosis of old age
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