skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Effect of prophylactic hyperbaric oxygen treatment for radiation-induced brain injury after stereotactic radiosurgery of brain metastases

Abstract

Purpose: The purpose of the present study was to evaluate the prophylactic effect of hyperbaric oxygen (HBO) therapy for radiation-induced brain injury in patients with brain metastasis treated with stereotactic radiosurgery (SRS). Methods and Materials: The data of 78 patients presenting with 101 brain metastases treated with SRS between October 1994 and September 2003 were retrospectively analyzed. A total of 32 patients with 47 brain metastases were treated with prophylactic HBO (HBO group), which included all 21 patients who underwent subsequent or prior radiotherapy and 11 patients with common predictors of longer survival, such as inactive extracranial tumors and younger age. The other 46 patients with 54 brain metastases did not undergo HBO (non-HBO group). Radiation-induced brain injuries were divided into two categories, white matter injury (WMI) and radiation necrosis (RN), on the basis of imaging findings. Results: Radiation-induced brain injury occurred in 5 lesions (11%) in the HBO group (2 WMIs and 3 RNs) and in 11 (20%) in the non-HBO group (9 WMIs and 2 RNs). The WMI was less frequent for the HBO group than for the non-HBO group (p = 0.05), although multivariate analysis by logistic regression showed that WMI was not significantly correlated with HBOmore » (p = 0.07). The 1-year actuarial probability of WMI was significantly better for the HBO group (2%) than for the non-HBO group (36%) (p < 0.05). Conclusions: The present study showed a potential value of prophylactic HBO for Radiation-induced WMIs, which justifies further evaluation to confirm its definite benefit.« less

Authors:
 [1];  [2];  [3];  [4];  [2];  [2];  [2];  [2];  [3];  [2]
  1. Department of Radiology, University of Occupational and Environmental Health, Kitakyushu (Japan). E-mail: ogurieye@med.uoeh-u.ac.jp
  2. Department of Radiology, University of Occupational and Environmental Health, Kitakyushu (Japan)
  3. Department of Hyperbaric Medicine, University of Occupational and Environmental Health, Kitakyushu (Japan)
  4. (Japan)
Publication Date:
OSTI Identifier:
20850322
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 67; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2006.08.009; PII: S0360-3016(06)02731-3; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; CARCINOMAS; EVALUATION; METASTASES; MULTIVARIATE ANALYSIS; NECROSIS; OXYGEN; PATIENTS; RADIATION INJURIES; RADIOTHERAPY; SURGERY

Citation Formats

Ohguri, Takayuki, Imada, Hajime, Kohshi, Kiyotaka, Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Kakeda, Shingo, Ohnari, Norihiro, Morioka, Tomoaki, Nakano, Keita, Konda, Nobuhide, and Korogi, Yukunori. Effect of prophylactic hyperbaric oxygen treatment for radiation-induced brain injury after stereotactic radiosurgery of brain metastases. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2006.08.009.
Ohguri, Takayuki, Imada, Hajime, Kohshi, Kiyotaka, Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Kakeda, Shingo, Ohnari, Norihiro, Morioka, Tomoaki, Nakano, Keita, Konda, Nobuhide, & Korogi, Yukunori. Effect of prophylactic hyperbaric oxygen treatment for radiation-induced brain injury after stereotactic radiosurgery of brain metastases. United States. doi:10.1016/j.ijrobp.2006.08.009.
Ohguri, Takayuki, Imada, Hajime, Kohshi, Kiyotaka, Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu, Kakeda, Shingo, Ohnari, Norihiro, Morioka, Tomoaki, Nakano, Keita, Konda, Nobuhide, and Korogi, Yukunori. Mon . "Effect of prophylactic hyperbaric oxygen treatment for radiation-induced brain injury after stereotactic radiosurgery of brain metastases". United States. doi:10.1016/j.ijrobp.2006.08.009.
@article{osti_20850322,
title = {Effect of prophylactic hyperbaric oxygen treatment for radiation-induced brain injury after stereotactic radiosurgery of brain metastases},
author = {Ohguri, Takayuki and Imada, Hajime and Kohshi, Kiyotaka and Department of Neurosurgery, University of Occupational and Environmental Health, Kitakyushu and Kakeda, Shingo and Ohnari, Norihiro and Morioka, Tomoaki and Nakano, Keita and Konda, Nobuhide and Korogi, Yukunori},
abstractNote = {Purpose: The purpose of the present study was to evaluate the prophylactic effect of hyperbaric oxygen (HBO) therapy for radiation-induced brain injury in patients with brain metastasis treated with stereotactic radiosurgery (SRS). Methods and Materials: The data of 78 patients presenting with 101 brain metastases treated with SRS between October 1994 and September 2003 were retrospectively analyzed. A total of 32 patients with 47 brain metastases were treated with prophylactic HBO (HBO group), which included all 21 patients who underwent subsequent or prior radiotherapy and 11 patients with common predictors of longer survival, such as inactive extracranial tumors and younger age. The other 46 patients with 54 brain metastases did not undergo HBO (non-HBO group). Radiation-induced brain injuries were divided into two categories, white matter injury (WMI) and radiation necrosis (RN), on the basis of imaging findings. Results: Radiation-induced brain injury occurred in 5 lesions (11%) in the HBO group (2 WMIs and 3 RNs) and in 11 (20%) in the non-HBO group (9 WMIs and 2 RNs). The WMI was less frequent for the HBO group than for the non-HBO group (p = 0.05), although multivariate analysis by logistic regression showed that WMI was not significantly correlated with HBO (p = 0.07). The 1-year actuarial probability of WMI was significantly better for the HBO group (2%) than for the non-HBO group (36%) (p < 0.05). Conclusions: The present study showed a potential value of prophylactic HBO for Radiation-induced WMIs, which justifies further evaluation to confirm its definite benefit.},
doi = {10.1016/j.ijrobp.2006.08.009},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 1,
volume = 67,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}