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Title: Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy

Abstract

Purpose: To identify the dose-volumetric parameters associated with the risk of radiation-induced hepatic toxicity (RIHT) in hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy. Methods and Materials: A total of 105 hepatocellular carcinoma patients underwent three-dimensional conformal radiotherapy (total dose range, 44-58.5 Gy; median, 54). RIHT was scored within 4 months of completing three-dimensional conformal radiotherapy. The dose-volume parameters analyzed were the gross tumor volume; normal liver volume; total liver volume; radiation dose; mean dose to the normal liver; percentage of the normal liver volume receiving {>=}20, {>=}25, {>=}30, {>=}35, and {>=}40 Gy; percentage of the total liver volume receiving {>=}20, {>=}25, {>=}30, {>=}35, and {>=}40 Gy; and the normal tissue complication probability. Results: Of the 105 patients, Grade 1 RIHT was observed in 21 (20.0%), Grade 2 in 7 (6.7%), Grade 3 in 5 (4.8%), and Grade 4 in 1 (1.0%) patient. No fatal Grade 5 RIHT developed. On multivariate analysis for predicting Grade 2 or worse RIHT, the total liver volume receiving {>=}30 Gy was the only significant parameter (p < 0.001). Grade 2 or worse RIHT was observed in only 2 (2.4%) of 85 patients with a total liver volume receiving 30 Gy of {<=}60% and inmore » 11 (55.0%) of 20 patients with >60% (p < 0.001). Conclusion: The total liver volume receiving {>=}30 Gy appears to be a useful dose-volumetric parameter for predicting the risk of RIHT. This volume should be limited to {<=}60% whenever possible to minimize the risk of Grade 2 or worse RIHT.« less

Authors:
 [1];  [2];  [1];  [1];  [1];  [1];  [1];  [1];  [1];  [1]
  1. Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of)
  2. Research Institute and Hospital, National Cancer Center, Goyang (Korea, Republic of). E-mail: radiopia@ncc.re.kr
Publication Date:
OSTI Identifier:
20850318
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 67; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2006.08.015; PII: S0360-3016(06)02768-4; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEALTH HAZARDS; HEPATOMAS; LIVER; MULTIVARIATE ANALYSIS; PATIENTS; RADIATION DOSES; RADIOTHERAPY; TOXICITY

Citation Formats

Kim, Tae Hyun, Kim, Dae Yong, Park, Joong-Won, Kim, Seong Hoon, Choi, Joon-Il, Kim, Hyun Beom, Lee, Woo Jin, Park, Sang Jae, Hong, Eun Kyung, and Kim, Chang-Min. Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2006.08.015.
Kim, Tae Hyun, Kim, Dae Yong, Park, Joong-Won, Kim, Seong Hoon, Choi, Joon-Il, Kim, Hyun Beom, Lee, Woo Jin, Park, Sang Jae, Hong, Eun Kyung, & Kim, Chang-Min. Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy. United States. doi:10.1016/j.ijrobp.2006.08.015.
Kim, Tae Hyun, Kim, Dae Yong, Park, Joong-Won, Kim, Seong Hoon, Choi, Joon-Il, Kim, Hyun Beom, Lee, Woo Jin, Park, Sang Jae, Hong, Eun Kyung, and Kim, Chang-Min. Mon . "Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy". United States. doi:10.1016/j.ijrobp.2006.08.015.
@article{osti_20850318,
title = {Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy},
author = {Kim, Tae Hyun and Kim, Dae Yong and Park, Joong-Won and Kim, Seong Hoon and Choi, Joon-Il and Kim, Hyun Beom and Lee, Woo Jin and Park, Sang Jae and Hong, Eun Kyung and Kim, Chang-Min},
abstractNote = {Purpose: To identify the dose-volumetric parameters associated with the risk of radiation-induced hepatic toxicity (RIHT) in hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy. Methods and Materials: A total of 105 hepatocellular carcinoma patients underwent three-dimensional conformal radiotherapy (total dose range, 44-58.5 Gy; median, 54). RIHT was scored within 4 months of completing three-dimensional conformal radiotherapy. The dose-volume parameters analyzed were the gross tumor volume; normal liver volume; total liver volume; radiation dose; mean dose to the normal liver; percentage of the normal liver volume receiving {>=}20, {>=}25, {>=}30, {>=}35, and {>=}40 Gy; percentage of the total liver volume receiving {>=}20, {>=}25, {>=}30, {>=}35, and {>=}40 Gy; and the normal tissue complication probability. Results: Of the 105 patients, Grade 1 RIHT was observed in 21 (20.0%), Grade 2 in 7 (6.7%), Grade 3 in 5 (4.8%), and Grade 4 in 1 (1.0%) patient. No fatal Grade 5 RIHT developed. On multivariate analysis for predicting Grade 2 or worse RIHT, the total liver volume receiving {>=}30 Gy was the only significant parameter (p < 0.001). Grade 2 or worse RIHT was observed in only 2 (2.4%) of 85 patients with a total liver volume receiving 30 Gy of {<=}60% and in 11 (55.0%) of 20 patients with >60% (p < 0.001). Conclusion: The total liver volume receiving {>=}30 Gy appears to be a useful dose-volumetric parameter for predicting the risk of RIHT. This volume should be limited to {<=}60% whenever possible to minimize the risk of Grade 2 or worse RIHT.},
doi = {10.1016/j.ijrobp.2006.08.015},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 1,
volume = 67,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}