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Title: A comparative study of volumetric analysis, histopathologic downstaging, and tumor regression grade in evaluating tumor response in locally advanced rectal cancer following preoperative chemoradiation

Abstract

Purpose: To compare tumor volume reduction rate, histopathologic downstaging, and tumor regression grade (TRG) among tumor responses in rectal cancer after preoperative chemoradiotherapy (CRT). Patients and Methods: Between 2002 and 2004, 30 patients with locally advanced rectal cancer underwent preoperative CRT, followed by surgical resection. Magnetic resonance volumetry was performed before and after CRT. Histopathologic tumor staging and tumor regression were reviewed. We compared pre- and post-CRT tumor volume and percent of volume reduction, according to histopathologic downstaging and TRG. Results: The tumor volume reduction rates ranged from 14.6% to 100%. Mean pre- and post-CRT tumor volumes were significantly smaller in patients who showed T downstaging than in those who did not (p 0.040, 0.014). The mean tumor volume reduction was 66.4% vs. 55.2% (p 0.361). However, the mean pre- and post-CRT tumor volume and mean tumor volume reduction rate between patients who showed N downstaging and those who did not were not statistically different (p = 0.176, 0.767, and 0.899). With respect to TRG, the mean pre- and post-CRT tumor volumes were not statistically significant (p = 0.108, 0.708, and 0.120). Conclusion: Tumor volume reduction rate does not correlate with histopathologic downstaging and TRG. It might be hazardous tomore » evaluate tumor response with respect to volume reduction and to select the surgical method on this basis.« less

Authors:
 [1];  [2];  [3];  [2];  [3];  [4];  [5];  [2];  [3];  [2];  [3];  [2];  [3];  [6];  [6]
  1. Colorectal Cancer Clinic Severance Hospital, Yonsei University Medical Center, Seoul (Korea, Republic of) and Department of Surgery, Yonsei University College of Medicine, Seoul (Korea, Republic of). E-mail: namkyuk@yumc.yonsei.ac.kr
  2. Colorectal Cancer Clinic Severance Hospital, Yonsei University Medical Center, Seoul (Korea, Republic of)
  3. (Korea, Republic of)
  4. National Cancer Center, Proton Therapy Center, Ilsan (Korea, Republic of)
  5. Department of Pathology, National Insurance Hospital, Ilsan (Korea, Republic of)
  6. Department of Medical Oncology, Yonsei University College of Medicine, Seoul (Korea, Republic of)
Publication Date:
OSTI Identifier:
20850315
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 67; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2006.08.020; PII: S0360-3016(06)02769-6; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; COMBINED THERAPY; NEOPLASMS; PATHOLOGICAL CHANGES; PATIENTS; SURGERY; VOLUMETRIC ANALYSIS

Citation Formats

Kim, Nam Kyu, Baik, Seung Hyuk, Department of Surgery, Yonsei University College of Medicine, Seoul, Min, Byung Soh, Department of Surgery, Yonsei University College of Medicine, Seoul, Pyo, Hong Ryull, Choi, Yun Jung, Kim, Hogeun, Department of Pathology, Yonsei University College of Medicine, Seoul, Seong, Jinsil, Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Keum, Ki Chang, Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Rha, Sun Young, and Chung, Hyun Cheol. A comparative study of volumetric analysis, histopathologic downstaging, and tumor regression grade in evaluating tumor response in locally advanced rectal cancer following preoperative chemoradiation. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2006.08.020.
Kim, Nam Kyu, Baik, Seung Hyuk, Department of Surgery, Yonsei University College of Medicine, Seoul, Min, Byung Soh, Department of Surgery, Yonsei University College of Medicine, Seoul, Pyo, Hong Ryull, Choi, Yun Jung, Kim, Hogeun, Department of Pathology, Yonsei University College of Medicine, Seoul, Seong, Jinsil, Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Keum, Ki Chang, Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Rha, Sun Young, & Chung, Hyun Cheol. A comparative study of volumetric analysis, histopathologic downstaging, and tumor regression grade in evaluating tumor response in locally advanced rectal cancer following preoperative chemoradiation. United States. doi:10.1016/j.ijrobp.2006.08.020.
Kim, Nam Kyu, Baik, Seung Hyuk, Department of Surgery, Yonsei University College of Medicine, Seoul, Min, Byung Soh, Department of Surgery, Yonsei University College of Medicine, Seoul, Pyo, Hong Ryull, Choi, Yun Jung, Kim, Hogeun, Department of Pathology, Yonsei University College of Medicine, Seoul, Seong, Jinsil, Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Keum, Ki Chang, Department of Radiation Oncology, Yonsei University College of Medicine, Seoul, Rha, Sun Young, and Chung, Hyun Cheol. Mon . "A comparative study of volumetric analysis, histopathologic downstaging, and tumor regression grade in evaluating tumor response in locally advanced rectal cancer following preoperative chemoradiation". United States. doi:10.1016/j.ijrobp.2006.08.020.
@article{osti_20850315,
title = {A comparative study of volumetric analysis, histopathologic downstaging, and tumor regression grade in evaluating tumor response in locally advanced rectal cancer following preoperative chemoradiation},
author = {Kim, Nam Kyu and Baik, Seung Hyuk and Department of Surgery, Yonsei University College of Medicine, Seoul and Min, Byung Soh and Department of Surgery, Yonsei University College of Medicine, Seoul and Pyo, Hong Ryull and Choi, Yun Jung and Kim, Hogeun and Department of Pathology, Yonsei University College of Medicine, Seoul and Seong, Jinsil and Department of Radiation Oncology, Yonsei University College of Medicine, Seoul and Keum, Ki Chang and Department of Radiation Oncology, Yonsei University College of Medicine, Seoul and Rha, Sun Young and Chung, Hyun Cheol},
abstractNote = {Purpose: To compare tumor volume reduction rate, histopathologic downstaging, and tumor regression grade (TRG) among tumor responses in rectal cancer after preoperative chemoradiotherapy (CRT). Patients and Methods: Between 2002 and 2004, 30 patients with locally advanced rectal cancer underwent preoperative CRT, followed by surgical resection. Magnetic resonance volumetry was performed before and after CRT. Histopathologic tumor staging and tumor regression were reviewed. We compared pre- and post-CRT tumor volume and percent of volume reduction, according to histopathologic downstaging and TRG. Results: The tumor volume reduction rates ranged from 14.6% to 100%. Mean pre- and post-CRT tumor volumes were significantly smaller in patients who showed T downstaging than in those who did not (p 0.040, 0.014). The mean tumor volume reduction was 66.4% vs. 55.2% (p 0.361). However, the mean pre- and post-CRT tumor volume and mean tumor volume reduction rate between patients who showed N downstaging and those who did not were not statistically different (p = 0.176, 0.767, and 0.899). With respect to TRG, the mean pre- and post-CRT tumor volumes were not statistically significant (p = 0.108, 0.708, and 0.120). Conclusion: Tumor volume reduction rate does not correlate with histopathologic downstaging and TRG. It might be hazardous to evaluate tumor response with respect to volume reduction and to select the surgical method on this basis.},
doi = {10.1016/j.ijrobp.2006.08.020},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 1,
volume = 67,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}