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Title: Intensity-modulated radiation therapy for malignancies of the nasal cavity and paranasal sinuses

Abstract

Purpose: To report the clinical outcome of patients treated with intensity-modulated radiation therapy (IMRT) for malignancies of the nasal cavity and paranasal sinuses. Methods and Materials: Between 1998 and 2004, 36 patients with malignancies of the sinonasal region were treated with IMRT. Thirty-two patients (89%) were treated in the postoperative setting after gross total resection. Treatment plans were designed to provide a dose of 70 Gy to 95% or more of the gross tumor volume (GTV) and 60 Gy to 95% or more of the clinical tumor volume (CTV) while sparing neighboring critical structures including the optic chiasm, optic nerves, eyes, and brainstem. The primary sites were: 13 ethmoid sinus, 10 maxillary sinus, 7 nasal cavity, and 6 other. Histology was: 12 squamous cell, 7 esthesioneuroblastoma, 5 adenoid cystic, 5 undifferentiated, 5 adenocarcinoma, and 2 other. Median follow-up was 51 months among surviving patients (range, 9-82 months). Results: The 2-year and 5-year estimates of local control were 62% and 58%, respectively. One patient developed isolated distant metastasis, and none developed isolated regional failure. The 5-year rates of disease-free and overall survival were 55% and 45%, respectively. The incidence of ocular toxicity was minimal with no patients reporting decreased vision. Latemore » complications included xerophthalmia (1 patient), lacrimal stenosis (1 patient), and cataract (1 patient). Conclusion: Although IMRT for malignancies of the sinonasal region does not appear to lead to significant improvements in disease control, the low incidence of complications is encouraging.« less

Authors:
 [1];  [2];  [1];  [3];  [1];  [4];  [3]
  1. Department of Radiation Oncology, University of California, San Francisco (UCSF) Comprehensive Cancer Center, San Francisco, CA (United States)
  2. Department of Radiation Oncology, University of California, San Francisco (UCSF) Comprehensive Cancer Center, San Francisco, CA (United States). E-mail: allenmchen@yahoo.com
  3. Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco (UCSF) Comprehensive Cancer Center, San Francisco, CA (United States)
  4. Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA (United States)
Publication Date:
OSTI Identifier:
20850308
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 67; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2006.07.1389; PII: S0360-3016(06)02822-7; Copyright (c) 2007 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; CATARACTS; EYES; FAILURES; HISTOLOGY; METASTASES; NERVES; PATIENTS; RADIATION DOSES; RADIOTHERAPY; SINUSES; TOXICITY

Citation Formats

Daly, Megan E., Chen, Allen M., Bucci, M. Kara, El-Sayed, Ivan, Xia Ping, Kaplan, Michael J., and Eisele, David W.. Intensity-modulated radiation therapy for malignancies of the nasal cavity and paranasal sinuses. United States: N. p., 2007. Web. doi:10.1016/j.ijrobp.2006.07.1389.
Daly, Megan E., Chen, Allen M., Bucci, M. Kara, El-Sayed, Ivan, Xia Ping, Kaplan, Michael J., & Eisele, David W.. Intensity-modulated radiation therapy for malignancies of the nasal cavity and paranasal sinuses. United States. doi:10.1016/j.ijrobp.2006.07.1389.
Daly, Megan E., Chen, Allen M., Bucci, M. Kara, El-Sayed, Ivan, Xia Ping, Kaplan, Michael J., and Eisele, David W.. Mon . "Intensity-modulated radiation therapy for malignancies of the nasal cavity and paranasal sinuses". United States. doi:10.1016/j.ijrobp.2006.07.1389.
@article{osti_20850308,
title = {Intensity-modulated radiation therapy for malignancies of the nasal cavity and paranasal sinuses},
author = {Daly, Megan E. and Chen, Allen M. and Bucci, M. Kara and El-Sayed, Ivan and Xia Ping and Kaplan, Michael J. and Eisele, David W.},
abstractNote = {Purpose: To report the clinical outcome of patients treated with intensity-modulated radiation therapy (IMRT) for malignancies of the nasal cavity and paranasal sinuses. Methods and Materials: Between 1998 and 2004, 36 patients with malignancies of the sinonasal region were treated with IMRT. Thirty-two patients (89%) were treated in the postoperative setting after gross total resection. Treatment plans were designed to provide a dose of 70 Gy to 95% or more of the gross tumor volume (GTV) and 60 Gy to 95% or more of the clinical tumor volume (CTV) while sparing neighboring critical structures including the optic chiasm, optic nerves, eyes, and brainstem. The primary sites were: 13 ethmoid sinus, 10 maxillary sinus, 7 nasal cavity, and 6 other. Histology was: 12 squamous cell, 7 esthesioneuroblastoma, 5 adenoid cystic, 5 undifferentiated, 5 adenocarcinoma, and 2 other. Median follow-up was 51 months among surviving patients (range, 9-82 months). Results: The 2-year and 5-year estimates of local control were 62% and 58%, respectively. One patient developed isolated distant metastasis, and none developed isolated regional failure. The 5-year rates of disease-free and overall survival were 55% and 45%, respectively. The incidence of ocular toxicity was minimal with no patients reporting decreased vision. Late complications included xerophthalmia (1 patient), lacrimal stenosis (1 patient), and cataract (1 patient). Conclusion: Although IMRT for malignancies of the sinonasal region does not appear to lead to significant improvements in disease control, the low incidence of complications is encouraging.},
doi = {10.1016/j.ijrobp.2006.07.1389},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 1,
volume = 67,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2007},
month = {Mon Jan 01 00:00:00 EST 2007}
}