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Title: Pretransplant pulmonary function tests predict risk of mortality following fractionated total body irradiation and allogeneic peripheral blood stem cell transplant

Abstract

Purpose: To determine the value of pulmonary function tests (PFTs) done before peripheral blood stem cell transplant (PBSCT) in predicting mortality after total body irradiation (TBI) performed with or without dose reduction to the lung. Methods and Materials: From 1997 to 2004, 146 consecutive patients with hematologic malignancies received fractionated TBI before PBSCT. With regimen A (n = 85), patients were treated without lung dose reduction to 13.6 gray (Gy). In regimen B (n = 35), total body dose was decreased to 12 Gy (1.5 Gy twice per day for 4 days) and lung dose was limited to 9 Gy by use of lung shielding. In regimen C (n = 26), lung dose was reduced to 6 Gy. All patients received PFTs before treatment, 90 days after treatment, and annually. Results: Median follow-up was 44 months (range, 12-90 months). Sixty-one patients had combined ventilation/diffusion capacity deficits defined as both a forced expiratory volume in the first second (FEV{sub 1}) and a diffusion capacity of carbon dioxide (DLCO) <100% predicted. In this group, there was a 20% improvement in one-year overall survival with lung dose reduction (70 vs. 50%, log-rank test p = 0.042). Conclusion: Among those with combined ventilation/diffusion capacitymore » deficits, lung dose reduction during TBI significantly improved survival.« less

Authors:
 [1];  [1];  [2];  [1];  [3];  [1];  [1];  [1];  [2];  [2]
  1. Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD (United States)
  2. National Heart Lung Blood Institute, National Institutes of Health, Bethesda, MD (United States)
  3. Department of Radiation Oncology, Washington University School of Medicine, Mallinckrodt Institute of Radiology, Siteman Cancer Center, St. Louis, MO (United States)
Publication Date:
OSTI Identifier:
20850130
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 66; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2006.05.023; PII: S0360-3016(06)00942-4; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD; CARCINOMAS; DIFFUSION; HEALTH HAZARDS; LUNGS; MORTALITY; PATIENTS; RADIATION DOSES; SHIELDING; STEM CELLS; TRANSPLANTS; VENTILATION; WHOLE-BODY IRRADIATION

Citation Formats

Singh, Anurag K, Karimpour, Shervin E, Savani, Bipin N, Guion, Peter M.S., Hope, Andrew J, Mansueti, John R, Ning, Holly, Altemus, Rosemary M. Ph.D., Wu, Colin O, and Barrett, A John. Pretransplant pulmonary function tests predict risk of mortality following fractionated total body irradiation and allogeneic peripheral blood stem cell transplant. United States: N. p., 2006. Web. doi:10.1016/j.ijrobp.2006.05.023.
Singh, Anurag K, Karimpour, Shervin E, Savani, Bipin N, Guion, Peter M.S., Hope, Andrew J, Mansueti, John R, Ning, Holly, Altemus, Rosemary M. Ph.D., Wu, Colin O, & Barrett, A John. Pretransplant pulmonary function tests predict risk of mortality following fractionated total body irradiation and allogeneic peripheral blood stem cell transplant. United States. https://doi.org/10.1016/j.ijrobp.2006.05.023
Singh, Anurag K, Karimpour, Shervin E, Savani, Bipin N, Guion, Peter M.S., Hope, Andrew J, Mansueti, John R, Ning, Holly, Altemus, Rosemary M. Ph.D., Wu, Colin O, and Barrett, A John. 2006. "Pretransplant pulmonary function tests predict risk of mortality following fractionated total body irradiation and allogeneic peripheral blood stem cell transplant". United States. https://doi.org/10.1016/j.ijrobp.2006.05.023.
@article{osti_20850130,
title = {Pretransplant pulmonary function tests predict risk of mortality following fractionated total body irradiation and allogeneic peripheral blood stem cell transplant},
author = {Singh, Anurag K and Karimpour, Shervin E and Savani, Bipin N and Guion, Peter M.S. and Hope, Andrew J and Mansueti, John R and Ning, Holly and Altemus, Rosemary M. Ph.D. and Wu, Colin O and Barrett, A John},
abstractNote = {Purpose: To determine the value of pulmonary function tests (PFTs) done before peripheral blood stem cell transplant (PBSCT) in predicting mortality after total body irradiation (TBI) performed with or without dose reduction to the lung. Methods and Materials: From 1997 to 2004, 146 consecutive patients with hematologic malignancies received fractionated TBI before PBSCT. With regimen A (n = 85), patients were treated without lung dose reduction to 13.6 gray (Gy). In regimen B (n = 35), total body dose was decreased to 12 Gy (1.5 Gy twice per day for 4 days) and lung dose was limited to 9 Gy by use of lung shielding. In regimen C (n = 26), lung dose was reduced to 6 Gy. All patients received PFTs before treatment, 90 days after treatment, and annually. Results: Median follow-up was 44 months (range, 12-90 months). Sixty-one patients had combined ventilation/diffusion capacity deficits defined as both a forced expiratory volume in the first second (FEV{sub 1}) and a diffusion capacity of carbon dioxide (DLCO) <100% predicted. In this group, there was a 20% improvement in one-year overall survival with lung dose reduction (70 vs. 50%, log-rank test p = 0.042). Conclusion: Among those with combined ventilation/diffusion capacity deficits, lung dose reduction during TBI significantly improved survival.},
doi = {10.1016/j.ijrobp.2006.05.023},
url = {https://www.osti.gov/biblio/20850130}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 2,
volume = 66,
place = {United States},
year = {Sun Oct 01 00:00:00 EDT 2006},
month = {Sun Oct 01 00:00:00 EDT 2006}
}