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Title: Effect of beam channel plugging on the outcome of gamma knife radiosurgery for trigeminal neuralgia

Abstract

Purpose: We studied the influence of using plugs for brainstem protection during gamma knife radiosurgery (GKR) of trigeminal neuralgia (TN), with special emphasis on irradiation doses delivered to the trigeminal nerve, pain outcomes, and incidence of trigeminal dysfunction. Methods and Materials: A GKR procedure for TN using an anterior cisternal target and a maximum dose of 90 Gy was performed in 109 patients. For 49 patients, customized beam channel blocking (plugs) were used to reduce the dose delivered to the brainstem. We measured the mean and integrated radiation doses delivered to the trigeminal nerve and the clinical course of patients treated with and without plugs. Results: We found that blocking increases the length of trigeminal nerve exposed to high-dose radiation, resulting in a significantly higher mean dose to the trigeminal nerve. Significantly more of the patients with blocking achieved excellent pain outcomes (84% vs. 62%), but with higher incidences of moderate and bothersome trigeminal nerve dysfunction (37% mild/10% bothersome with plugs vs. 30% mild/2% bothersome without). Conclusions: The use of plugs to protect the brainstem during GKR treatment for TN increases the dose of irradiation delivered to the intracisternal trigeminal nerve root and is associated with an important increase inmore » the incidence of trigeminal nerve dysfunction. Therefore, beam channel blocking should be avoided for 90 Gy-GKR of TN.« less

Authors:
 [1];  [2];  [3];  [2];  [2];  [2];  [3];  [2]
  1. Gamma Knife Center, Universite Libre de Bruxelles, Brussels (Belgium). E-mail: nmassage@ulb.ac.be
  2. Gamma Knife Center, Universite Libre de Bruxelles, Brussels (Belgium)
  3. Gamma Knife Center, CHU La Timone, Marseilles (France)
Publication Date:
OSTI Identifier:
20849997
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 65; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2006.01.043; PII: S0360-3016(06)00247-1; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BEAMS; IRRADIATION; PAIN; PATIENTS; RADIATION DOSES; RADIOTHERAPY; SAFETY; SURGERY

Citation Formats

Massager, Nicolas, Nissim, Ouzi, Murata, Noriko, Devriendt, Daniel, Desmedt, Francoise, Vanderlinden, Bruno, Regis, Jean, and Levivier, Marc. Effect of beam channel plugging on the outcome of gamma knife radiosurgery for trigeminal neuralgia. United States: N. p., 2006. Web. doi:10.1016/j.ijrobp.2006.01.043.
Massager, Nicolas, Nissim, Ouzi, Murata, Noriko, Devriendt, Daniel, Desmedt, Francoise, Vanderlinden, Bruno, Regis, Jean, & Levivier, Marc. Effect of beam channel plugging on the outcome of gamma knife radiosurgery for trigeminal neuralgia. United States. doi:10.1016/j.ijrobp.2006.01.043.
Massager, Nicolas, Nissim, Ouzi, Murata, Noriko, Devriendt, Daniel, Desmedt, Francoise, Vanderlinden, Bruno, Regis, Jean, and Levivier, Marc. Sat . "Effect of beam channel plugging on the outcome of gamma knife radiosurgery for trigeminal neuralgia". United States. doi:10.1016/j.ijrobp.2006.01.043.
@article{osti_20849997,
title = {Effect of beam channel plugging on the outcome of gamma knife radiosurgery for trigeminal neuralgia},
author = {Massager, Nicolas and Nissim, Ouzi and Murata, Noriko and Devriendt, Daniel and Desmedt, Francoise and Vanderlinden, Bruno and Regis, Jean and Levivier, Marc},
abstractNote = {Purpose: We studied the influence of using plugs for brainstem protection during gamma knife radiosurgery (GKR) of trigeminal neuralgia (TN), with special emphasis on irradiation doses delivered to the trigeminal nerve, pain outcomes, and incidence of trigeminal dysfunction. Methods and Materials: A GKR procedure for TN using an anterior cisternal target and a maximum dose of 90 Gy was performed in 109 patients. For 49 patients, customized beam channel blocking (plugs) were used to reduce the dose delivered to the brainstem. We measured the mean and integrated radiation doses delivered to the trigeminal nerve and the clinical course of patients treated with and without plugs. Results: We found that blocking increases the length of trigeminal nerve exposed to high-dose radiation, resulting in a significantly higher mean dose to the trigeminal nerve. Significantly more of the patients with blocking achieved excellent pain outcomes (84% vs. 62%), but with higher incidences of moderate and bothersome trigeminal nerve dysfunction (37% mild/10% bothersome with plugs vs. 30% mild/2% bothersome without). Conclusions: The use of plugs to protect the brainstem during GKR treatment for TN increases the dose of irradiation delivered to the intracisternal trigeminal nerve root and is associated with an important increase in the incidence of trigeminal nerve dysfunction. Therefore, beam channel blocking should be avoided for 90 Gy-GKR of TN.},
doi = {10.1016/j.ijrobp.2006.01.043},
journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 4,
volume = 65,
place = {United States},
year = {2006},
month = {7}
}