skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: On-off intermittency in time series of spontaneous paroxysmal activity in rats with genetic absence epilepsy

Abstract

In the present paper we consider the on-off intermittency phenomena observed in time series of spontaneous paroxysmal activity in rats with genetic absence epilepsy. The method to register and analyze the electroencephalogram with the help of continuous wavelet transform is also suggested.

Authors:
; ; ; ;  [1];  [2];  [3]
  1. Faculty of Nonlinear Processes, Saratov State University, Astrakhanskaya str., 83, Saratov, 410012 (Russian Federation)
  2. (Russian Federation)
  3. (Netherlands)
Publication Date:
OSTI Identifier:
20849476
Resource Type:
Journal Article
Resource Relation:
Journal Name: Chaos (Woodbury, N. Y.); Journal Volume: 16; Journal Issue: 4; Other Information: DOI: 10.1063/1.2360505; (c) 2006 American Institute of Physics; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; BIOPHYSICS; ELECTROENCEPHALOGRAPHY; EPILEPSY; NONLINEAR PROBLEMS; RATS; TIME-SERIES ANALYSIS

Citation Formats

Hramov, Alexander, Koronovskii, Alexey A., Midzyanovskaya, I.S., Sitnikova, E., Rijn, C.M. van, Institute of the Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Butlerova str., 5A, Moscow, 117485, and NICI-Biological Psychology, Radboud University Nijmegen, PO 9104, 6500 HE Nijmegen. On-off intermittency in time series of spontaneous paroxysmal activity in rats with genetic absence epilepsy. United States: N. p., 2006. Web. doi:10.1063/1.2360505.
Hramov, Alexander, Koronovskii, Alexey A., Midzyanovskaya, I.S., Sitnikova, E., Rijn, C.M. van, Institute of the Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Butlerova str., 5A, Moscow, 117485, & NICI-Biological Psychology, Radboud University Nijmegen, PO 9104, 6500 HE Nijmegen. On-off intermittency in time series of spontaneous paroxysmal activity in rats with genetic absence epilepsy. United States. doi:10.1063/1.2360505.
Hramov, Alexander, Koronovskii, Alexey A., Midzyanovskaya, I.S., Sitnikova, E., Rijn, C.M. van, Institute of the Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Butlerova str., 5A, Moscow, 117485, and NICI-Biological Psychology, Radboud University Nijmegen, PO 9104, 6500 HE Nijmegen. Fri . "On-off intermittency in time series of spontaneous paroxysmal activity in rats with genetic absence epilepsy". United States. doi:10.1063/1.2360505.
@article{osti_20849476,
title = {On-off intermittency in time series of spontaneous paroxysmal activity in rats with genetic absence epilepsy},
author = {Hramov, Alexander and Koronovskii, Alexey A. and Midzyanovskaya, I.S. and Sitnikova, E. and Rijn, C.M. van and Institute of the Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, Butlerova str., 5A, Moscow, 117485 and NICI-Biological Psychology, Radboud University Nijmegen, PO 9104, 6500 HE Nijmegen},
abstractNote = {In the present paper we consider the on-off intermittency phenomena observed in time series of spontaneous paroxysmal activity in rats with genetic absence epilepsy. The method to register and analyze the electroencephalogram with the help of continuous wavelet transform is also suggested.},
doi = {10.1063/1.2360505},
journal = {Chaos (Woodbury, N. Y.)},
number = 4,
volume = 16,
place = {United States},
year = {Fri Dec 15 00:00:00 EST 2006},
month = {Fri Dec 15 00:00:00 EST 2006}
}
  • To discuss the salient role of statistical memory effects in human brain functioning, we have analyzed a set of stochastic memory quantifiers that reflects the dynamical characteristics of neuromagnetic responses of magnetoencephalographic signals to a flickering stimulus of different color combinations from a group of control subjects, and compared them with those for a patient with photosensitive epilepsy. We have discovered that the emergence of strong memory and the accompanying transition to a regular and robust regime of chaotic behavior of signals in separate areas for a patient most likely identifies the regions where the protective mechanism against the occurrencemore » of photosensitive epilepsy is located.« less
  • Diabetes-prone BB/Wor (DP) rats lack the RT6+ peripheral T cell subset whereas diabetes-resistant BB/Wor rats have normal numbers of RT6+ T cells. Lymphocyte transfusion experiments and in vivo depletion studies have demonstrated that RT6+ T cells have an important regulatory role in the pathogenesis of insulin-dependent diabetes mellitus in BB/Wor rats. In the present study, the results of genetic complementation studies indicate that the DP rat contains an intact RT6 gene, but fails to express the RT6.1 alloantigen in the functional absence of an accessory factor (provided by RT6+ cells). At the cellular level, irradiation chimeras demonstrate that the absencemore » of RT6+ T cells in DP rats is due to an intrinsic defect that results in abnormal development and/or differentiation of prothymocytes into RT6+ T cells. The inability of DP prothymocytes to generate RT6+ T cells is not due to serum autoantibodies, lack of accessory cells, or to the presence of inhibitory cells. Inasmuch as DP bone marrow can transfer the susceptibility for diabetes to irradiated recipients, our present results suggest that an important predisposing factor for insulin-dependent diabetes mellitus in DP rats is the inability of DP prothymocytes to generate RT6+ T cells.« less
  • Juvenile myoclonic epilepsy (JME) is a common form of primary idiopathic generalized epilepsy characterized by myoclonias, tonic-clonic or clonic tonic-clonic convulsions and absences. Ictal electroencephalograms (EEGs) show high amplitude multispikes folowed by slow waves and interictal EEGs manifest 3.5-6 Hz diffuse multispike wave complexes. JME affected about 7-10% of patients with epilepsies and its onset peaks between 13-15 years of age. We recently mapped a JME locus on chromosome 6p21.1-6p11 by linkage analysis of one relatively large JME family from Los Angeles and Belize. Assuming autosomal dominant inheritance with 70% penetrance, pairwise analyses tightly linked JME to D6S257 (Z =more » 3.67), D6S428 (Z = 3.08) and D6S272 (Z = 3.56) at {theta} = 0, m = f. Recombination and multipoints linkage analysis also suggested a locus is between markers D6S257 and D6S272. We then screened three relatively larger Mexican JME pedigrees with D6S257, D6S272, D6S282, TNF, D6S276, D6S273, D6S105 and F13A1 on chromosome 6p. Assuming autosomal dominant inheritance with incomplete penetrance, linkage to chromosome 6p DNA markers are excluded. Our findings underline the genetic heterogeneity of juvenile myoclonic epilepsy.« less
  • Recently, six families with a familial form of partial epilepsy were described. All pedigrees showed autosomal dominant inheritance with incomplete penetrance. Affected individuals present with predominantly nocturnal seizures with frontal lobe semiology. In 1959, a genetic mouse model for partial epilepsy, the El mouse, was reported. In the El mouse, a major seizure susceptibility gene, El-1, segregates in an autosomal dominant fashion and has been localized to a region distal to the centromere of mouse chromosome 9. Comparative genetic maps between man and mouse have been used for prediction of localization of several human disease genes. Because the region ofmore » mouse chromosome 9 that is the most likely to contain the El-1 locus is syntenic to regions on human chromosomes 3q21-p22, 3q21-q23.3, 6q12 and 15q24, we adopted the candidate gene approach as an initial linkage strategy. Twenty-two polymorphic microsatellite markers covering these regions were used for genotyping individuals in the three larger families ascertained, two of which are Australian and one French-Canadian. Negative two-point lod scores were obtained separately for each family. The analysis of all three families combined significantly excludes the candidate regions on chromosomes 3, 6 and 15.« less
  • Neocortical high-voltage spike-and-wave discharges (HVS) in the rat are an animal model of petit mal epilepsy. Genetic analysis of total duration of HVS (s/12 hr) in reciprocal F1 and F2 hybrids of F344 and BN rats indicated that the phenotypic variability of HVS cannot be explained by simple, monogenic Mendelian model. Biometrical analysis suggested the presence of additive, dominance, and sex-linked-epistatic effects, buffering maternal influence, and heterosis. High correlation was observed between average duration (s/episode) and frequency of occurrence of spike-and-wave episodes (n/12 hr) in parental and segregating generations, indicating that common genes affect both duration and frequency of themore » spike-and-wave pattern. We propose that both genetic and developmental - environmental factors control an underlying quantitative variable, which, above a certain threshold level, precipitates HVS discharges. These findings, together with the recent availability of rat DNA markers for total genome mapping, pave the way to the identification of genes that control the susceptibility of the brain to spike-and-wave discharges. 67 refs., 3 figs., 5 tabs.« less