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Title: Cerium and yttrium oxide nanoparticles are neuroprotective

Abstract

The responses of cells exposed to nanoparticles have been studied with regard to toxicity, but very little attention has been paid to the possibility that some types of particles can protect cells from various forms of lethal stress. It is shown here that nanoparticles composed of cerium oxide or yttrium oxide protect nerve cells from oxidative stress and that the neuroprotection is independent of particle size. The ceria and yttria nanoparticles act as direct antioxidants to limit the amount of reactive oxygen species required to kill the cells. It follows that this group of nanoparticles could be used to modulate oxidative stress in biological systems.

Authors:
 [1];  [2];  [3];  [3]
  1. Salk Institute, 10010 N. Torrey Pines Rd., La Jolla, CA 92037 (United States). E-mail: schubert@salk.edu
  2. Salk Institute, 10010 N. Torrey Pines Rd., La Jolla, CA 92037 (United States)
  3. Columbia University, Departments of Applied Physics and Applied Mathematics, 1136 Mudd, MC 4701, New York, NY 10027 (United States)
Publication Date:
OSTI Identifier:
20798867
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 342; Journal Issue: 1; Other Information: DOI: 10.1016/j.bbrc.2006.01.129; PII: S0006-291X(06)00214-2; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; ANTIOXIDANTS; BIOLOGICAL STRESS; CERIUM; CERIUM OXIDES; NANOSTRUCTURES; NERVE CELLS; PARTICLE SIZE; TOXICITY; YTTRIUM OXIDES

Citation Formats

Schubert, David, Dargusch, Richard, Raitano, Joan, and Chan, S.-W. Cerium and yttrium oxide nanoparticles are neuroprotective. United States: N. p., 2006. Web. doi:10.1016/j.bbrc.2006.01.129.
Schubert, David, Dargusch, Richard, Raitano, Joan, & Chan, S.-W. Cerium and yttrium oxide nanoparticles are neuroprotective. United States. doi:10.1016/j.bbrc.2006.01.129.
Schubert, David, Dargusch, Richard, Raitano, Joan, and Chan, S.-W. Fri . "Cerium and yttrium oxide nanoparticles are neuroprotective". United States. doi:10.1016/j.bbrc.2006.01.129.
@article{osti_20798867,
title = {Cerium and yttrium oxide nanoparticles are neuroprotective},
author = {Schubert, David and Dargusch, Richard and Raitano, Joan and Chan, S.-W.},
abstractNote = {The responses of cells exposed to nanoparticles have been studied with regard to toxicity, but very little attention has been paid to the possibility that some types of particles can protect cells from various forms of lethal stress. It is shown here that nanoparticles composed of cerium oxide or yttrium oxide protect nerve cells from oxidative stress and that the neuroprotection is independent of particle size. The ceria and yttria nanoparticles act as direct antioxidants to limit the amount of reactive oxygen species required to kill the cells. It follows that this group of nanoparticles could be used to modulate oxidative stress in biological systems.},
doi = {10.1016/j.bbrc.2006.01.129},
journal = {Biochemical and Biophysical Research Communications},
number = 1,
volume = 342,
place = {United States},
year = {Fri Mar 31 00:00:00 EST 2006},
month = {Fri Mar 31 00:00:00 EST 2006}
}