skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Preliminary results of a phase I/II study of simultaneous modulated accelerated radiotherapy for nondisseminated nasopharyngeal carcinoma

Abstract

Purpose: To present preliminary results of intensity-modulated radiotherapy (IMRT) with the simultaneous modulated accelerated radiotherapy (SMART) boost technique in patients with nasopharyngeal carcinoma (NPC). Methods and Materials: Twenty patients who underwent IMRT for nondisseminated NPC at the Asan Medical Center between September 2001 and December 2003 were prospectively evaluated. Intensity-modulated radiotherapy was delivered with the 'step and shoot' SMART technique at prescribed doses of 72 Gy (2.4 Gy/day) to the gross tumor volume, 60 Gy (2 Gy/day) to the clinical target volume and metastatic nodal station, and 46 Gy (2 Gy/day) to the clinically negative neck region. Eighteen patients also received cisplatin once per week. Results: The median follow-up period was 27 months. Nineteen patients completed the treatment without interruption; the remaining patient interrupted treatment for 2 weeks owing to severe pharyngitis and malnutrition. Five patients (25%) had Radiation Therapy Oncology Group Grade 3 mucositis, whereas 9 (45%) had Grade 3 pharyngitis. Seven patients (35%) lost more than 10% of their pretreatment weight, whereas 11 (55%) required intravenous fluids and/or tube feeding. There was no Grade 3 or 4 xerostomia. All patients showed complete response. Two patients had distant metastases and locoregional recurrence, respectively. Conclusion: Intensity-modulated radiotherapy with the SMARTmore » boost technique allows parotid sparing, as shown clinically and by dosimetry, and might also be more effective biologically. A larger population of patients and a longer follow-up period are needed to evaluate ultimate tumor control and late toxicity.« less

Authors:
 [1];  [2];  [2];  [2];  [2]; ;  [2];  [3];  [3];  [3];  [3];  [4];  [2];  [5]; ;  [6]
  1. Department of Radiation Oncology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul (Korea, Republic of). E-mail: lsw@amc.seoul.kr
  2. Department of Radiation Oncology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul (Korea, Republic of)
  3. Department of Otolaryngology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul (Korea, Republic of)
  4. Dept. of Medical Oncology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul (Korea, Republic of)
  5. Department of Radiation Oncology, School of Medicine, Wonkwang University, Icksan (Korea, Republic of)
  6. Dept. of Radiation Oncology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul (Korea, Republic of)
Publication Date:
OSTI Identifier:
20793469
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 65; Journal Issue: 1; Other Information: DOI: 10.1016/j.ijrobp.2005.10.040; PII: S0360-3016(05)02963-9; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; COMBINED THERAPY; DOSIMETRY; MEDICAL ESTABLISHMENTS; METASTASES; NECK; PATIENTS; RADIATION DOSES; RADIOTHERAPY; TOXICITY

Citation Formats

Lee, Sang-wook, Back, Geum Mun, Yi, Byong Yong, Choi, Eun Kyung, Ahn, Seung Do, Shin, Seong Soo, Kim, Jung-hun, Kim, Sang Yoon, Lee, Bong-Jae, Nam, Soon Yuhl, Choi, Seung-Ho, Kim, Seung-Bae, Park, Jin-hong, Lee, Kang Kyoo, Park, Sung Ho, and Kim, Jong Hoon. Preliminary results of a phase I/II study of simultaneous modulated accelerated radiotherapy for nondisseminated nasopharyngeal carcinoma. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.1.
Lee, Sang-wook, Back, Geum Mun, Yi, Byong Yong, Choi, Eun Kyung, Ahn, Seung Do, Shin, Seong Soo, Kim, Jung-hun, Kim, Sang Yoon, Lee, Bong-Jae, Nam, Soon Yuhl, Choi, Seung-Ho, Kim, Seung-Bae, Park, Jin-hong, Lee, Kang Kyoo, Park, Sung Ho, & Kim, Jong Hoon. Preliminary results of a phase I/II study of simultaneous modulated accelerated radiotherapy for nondisseminated nasopharyngeal carcinoma. United States. doi:10.1016/J.IJROBP.2005.1.
Lee, Sang-wook, Back, Geum Mun, Yi, Byong Yong, Choi, Eun Kyung, Ahn, Seung Do, Shin, Seong Soo, Kim, Jung-hun, Kim, Sang Yoon, Lee, Bong-Jae, Nam, Soon Yuhl, Choi, Seung-Ho, Kim, Seung-Bae, Park, Jin-hong, Lee, Kang Kyoo, Park, Sung Ho, and Kim, Jong Hoon. Mon . "Preliminary results of a phase I/II study of simultaneous modulated accelerated radiotherapy for nondisseminated nasopharyngeal carcinoma". United States. doi:10.1016/J.IJROBP.2005.1.
@article{osti_20793469,
title = {Preliminary results of a phase I/II study of simultaneous modulated accelerated radiotherapy for nondisseminated nasopharyngeal carcinoma},
author = {Lee, Sang-wook and Back, Geum Mun and Yi, Byong Yong and Choi, Eun Kyung and Ahn, Seung Do and Shin, Seong Soo and Kim, Jung-hun and Kim, Sang Yoon and Lee, Bong-Jae and Nam, Soon Yuhl and Choi, Seung-Ho and Kim, Seung-Bae and Park, Jin-hong and Lee, Kang Kyoo and Park, Sung Ho and Kim, Jong Hoon},
abstractNote = {Purpose: To present preliminary results of intensity-modulated radiotherapy (IMRT) with the simultaneous modulated accelerated radiotherapy (SMART) boost technique in patients with nasopharyngeal carcinoma (NPC). Methods and Materials: Twenty patients who underwent IMRT for nondisseminated NPC at the Asan Medical Center between September 2001 and December 2003 were prospectively evaluated. Intensity-modulated radiotherapy was delivered with the 'step and shoot' SMART technique at prescribed doses of 72 Gy (2.4 Gy/day) to the gross tumor volume, 60 Gy (2 Gy/day) to the clinical target volume and metastatic nodal station, and 46 Gy (2 Gy/day) to the clinically negative neck region. Eighteen patients also received cisplatin once per week. Results: The median follow-up period was 27 months. Nineteen patients completed the treatment without interruption; the remaining patient interrupted treatment for 2 weeks owing to severe pharyngitis and malnutrition. Five patients (25%) had Radiation Therapy Oncology Group Grade 3 mucositis, whereas 9 (45%) had Grade 3 pharyngitis. Seven patients (35%) lost more than 10% of their pretreatment weight, whereas 11 (55%) required intravenous fluids and/or tube feeding. There was no Grade 3 or 4 xerostomia. All patients showed complete response. Two patients had distant metastases and locoregional recurrence, respectively. Conclusion: Intensity-modulated radiotherapy with the SMART boost technique allows parotid sparing, as shown clinically and by dosimetry, and might also be more effective biologically. A larger population of patients and a longer follow-up period are needed to evaluate ultimate tumor control and late toxicity.},
doi = {10.1016/J.IJROBP.2005.1},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 1,
volume = 65,
place = {United States},
year = {Mon May 01 00:00:00 EDT 2006},
month = {Mon May 01 00:00:00 EDT 2006}
}