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Title: Intraoperative electron boost radiation followed by moderate doses of external beam radiotherapy in limb-sparing treatment of patients with extremity soft-tissue sarcoma

Abstract

Purpose: To analyze long-term prognosis and morbidity after limb-sparing treatment of patients with extremity soft-tissue sarcoma, with intraoperative electron boost radiotherapy (IOERT) followed by a moderate dose of external beam radiotherapy (EBRT). Methods and Materials: A total of 153 patients who were treated in a single center from 1991 to 2004 were evaluated. Median IOERT dose was 15 Gy, mean EBRT dose 43 Gy (range, 40-50.4 Gy) in conventional fractionation (1.8-2 Gy). Median duration of follow-up was 33 months. Acute toxicity was assessed with Common Toxicity Criteria; late toxic effects were scored according to European Organization for Research and Treatment of Cancer/Radiation Therapy Oncology Group criteria. Results: Five-year overall survival and 5-year local control rates were 77% and 78%, respectively. Whereas tumor size, patient age, and EBRT dose did not significantly affect outcome, resection status and grading were significant for survival; resection status and IOERT dose were significant for local control. Extremity salvage until death or time of follow-up was achieved in 90% of our patients, 86% of whom showed excellent limb function without impairment in activities of daily life. Acute toxicity Grade 2-4 was observed in 23% and late toxicity Grade 2-4 in 17% of patients. Conclusions: Treatment withmore » IOERT combined with moderate doses of external beam irradiation yields high local control and extremity preservation rates in resected extremity soft-tissue sarcoma.« less

Authors:
 [1];  [1];  [2];  [1];  [1];  [1];  [1];  [1];  [1];  [3];  [4];  [5];  [4];  [2];  [1];  [6]
  1. Department of Radiation Oncology, University of Heidelberg, Heidelberg (Germany)
  2. Department of Orthopedics, University of Heidelberg, Heidelberg (Germany)
  3. Department of Radiation Oncology, German Cancer Research Center, Heidelberg (Germany)
  4. Department of Surgery, University of Heidelberg, Heidelberg (Germany)
  5. Department of Radiation Oncology, RWTH Aachen University, Aachen (Germany)
  6. Department of Radiation Oncology, University of Heidelberg, Heidelberg (Germany). E-mail: robert_krempien@med.uni-heidelberg.de
Publication Date:
OSTI Identifier:
20793427
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 64; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2005.10.009; PII: S0360-3016(05)02812-9; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BEAMS; DEATH; FRACTIONATED IRRADIATION; LIMBS; PATIENTS; PRESERVATION; RADIATION DOSES; RADIOTHERAPY; SARCOMAS; TOXICITY

Citation Formats

Oertel, Susanne, Treiber, Martina, Zahlten-Hinguranage, Angelika, Eichin, Steffen, Roeder, Falk, Funk, Angela, Hensley, Frank W., Timke, Carmen, Niethammer, Andreas G., Huber, Peter E., Weitz, Juergen, Eble, Micheal J., Buchler, Markus W., Bernd, Ludger, Debus, Juergen, and Krempien, Robert C. Intraoperative electron boost radiation followed by moderate doses of external beam radiotherapy in limb-sparing treatment of patients with extremity soft-tissue sarcoma. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.1.
Oertel, Susanne, Treiber, Martina, Zahlten-Hinguranage, Angelika, Eichin, Steffen, Roeder, Falk, Funk, Angela, Hensley, Frank W., Timke, Carmen, Niethammer, Andreas G., Huber, Peter E., Weitz, Juergen, Eble, Micheal J., Buchler, Markus W., Bernd, Ludger, Debus, Juergen, & Krempien, Robert C. Intraoperative electron boost radiation followed by moderate doses of external beam radiotherapy in limb-sparing treatment of patients with extremity soft-tissue sarcoma. United States. doi:10.1016/J.IJROBP.2005.1.
Oertel, Susanne, Treiber, Martina, Zahlten-Hinguranage, Angelika, Eichin, Steffen, Roeder, Falk, Funk, Angela, Hensley, Frank W., Timke, Carmen, Niethammer, Andreas G., Huber, Peter E., Weitz, Juergen, Eble, Micheal J., Buchler, Markus W., Bernd, Ludger, Debus, Juergen, and Krempien, Robert C. Sat . "Intraoperative electron boost radiation followed by moderate doses of external beam radiotherapy in limb-sparing treatment of patients with extremity soft-tissue sarcoma". United States. doi:10.1016/J.IJROBP.2005.1.
@article{osti_20793427,
title = {Intraoperative electron boost radiation followed by moderate doses of external beam radiotherapy in limb-sparing treatment of patients with extremity soft-tissue sarcoma},
author = {Oertel, Susanne and Treiber, Martina and Zahlten-Hinguranage, Angelika and Eichin, Steffen and Roeder, Falk and Funk, Angela and Hensley, Frank W. and Timke, Carmen and Niethammer, Andreas G. and Huber, Peter E. and Weitz, Juergen and Eble, Micheal J. and Buchler, Markus W. and Bernd, Ludger and Debus, Juergen and Krempien, Robert C.},
abstractNote = {Purpose: To analyze long-term prognosis and morbidity after limb-sparing treatment of patients with extremity soft-tissue sarcoma, with intraoperative electron boost radiotherapy (IOERT) followed by a moderate dose of external beam radiotherapy (EBRT). Methods and Materials: A total of 153 patients who were treated in a single center from 1991 to 2004 were evaluated. Median IOERT dose was 15 Gy, mean EBRT dose 43 Gy (range, 40-50.4 Gy) in conventional fractionation (1.8-2 Gy). Median duration of follow-up was 33 months. Acute toxicity was assessed with Common Toxicity Criteria; late toxic effects were scored according to European Organization for Research and Treatment of Cancer/Radiation Therapy Oncology Group criteria. Results: Five-year overall survival and 5-year local control rates were 77% and 78%, respectively. Whereas tumor size, patient age, and EBRT dose did not significantly affect outcome, resection status and grading were significant for survival; resection status and IOERT dose were significant for local control. Extremity salvage until death or time of follow-up was achieved in 90% of our patients, 86% of whom showed excellent limb function without impairment in activities of daily life. Acute toxicity Grade 2-4 was observed in 23% and late toxicity Grade 2-4 in 17% of patients. Conclusions: Treatment with IOERT combined with moderate doses of external beam irradiation yields high local control and extremity preservation rates in resected extremity soft-tissue sarcoma.},
doi = {10.1016/J.IJROBP.2005.1},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 64,
place = {United States},
year = {Sat Apr 01 00:00:00 EST 2006},
month = {Sat Apr 01 00:00:00 EST 2006}
}