skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Intraoperative radiotherapy given as a boost for early breast cancer: Long-term clinical and cosmetic results

Abstract

Purpose: The standard radiotherapy (RT) of breast cancer consists of 50 Gy external beam RT (EBRT) to the whole breast followed by an electron boost of 10-16 Gy to the tumor bed, but this has several cosmetic disadvantages. Intraoperative radiotherapy (IORT) could be an alternative to overcome these. Methods and Materials: We evaluated 50 women with early breast cancer operated on in a dedicated IORT facility. Median dose of 10 Gy was delivered using 9-MeV electron beams. All patients received postoperative EBRT (50 Gy in 2 Gy fractions). Late toxicity and cosmetic results were assessed independently by two physicians according to the Common Terminology Criteria for Adverse Event v3.0 grading system and the European Organization for Research and Treatment of Cancer questionnaires. Results: After a median follow-up of 9.1 years (range, 5-15 years), two local recurrences were observed within the primary tumor bed. At the time of analysis, 45 patients are alive with (n = 1) or without disease. Among the 42 disease-free remaining patients, 6 experienced Grade 2 late subcutaneous fibrosis within the boost area. Overall, the scores indicated a very good quality of life and cosmesis was good to excellent in the evaluated patients. Conclusion: Our results confirmmore » that IORT given as a boost after breast-conserving surgery is a reliable alternative to conventional postoperative fractionated boost radiation.« less

Authors:
 [1];  [2];  [3];  [4];  [4];  [4];  [5];  [5];  [1];  [6]
  1. Department of Radiation Oncology, Val d'Aurelle Cancer Institute, Montpellier (France)
  2. Department of Radiation Oncology, Val d'Aurelle Cancer Institute, Montpellier (France) and INSERM, Research Cancer Center of Montpellier, Val d'Aurelle Cancer Institute, Montpellier (France). E-mail: azria@valdorel.fnclcc.fr
  3. Biostatistics Unit, Val d'Aurelle Cancer Institute, Montpellier (France)
  4. Department of Surgical and Reconstructive Oncology, Val d'Aurelle Cancer Institute, Montpellier (France)
  5. Radiophysics Unit, Val d'Aurelle Cancer Institute, Montpellier (France)
  6. (France)
Publication Date:
OSTI Identifier:
20793426
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 64; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2005.10.025; PII: S0360-3016(05)02870-1; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ELECTRON BEAMS; FIBROSIS; MAMMARY GLANDS; PATIENTS; RADIOTHERAPY; SURGERY; TOXICITY; WOMEN

Citation Formats

Lemanski, Claire, Azria, David, Thezenas, Simon, Gutowski, Marian, Saint-Aubert, Bernard, Rouanet, Philippe, Fenoglietto, Pascal, Ailleres, Norbert, Dubois, Jean-Bernard, and INSERM, Research Cancer Center of Montpellier, Val d'Aurelle Cancer Institute, Montpellier. Intraoperative radiotherapy given as a boost for early breast cancer: Long-term clinical and cosmetic results. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.1.
Lemanski, Claire, Azria, David, Thezenas, Simon, Gutowski, Marian, Saint-Aubert, Bernard, Rouanet, Philippe, Fenoglietto, Pascal, Ailleres, Norbert, Dubois, Jean-Bernard, & INSERM, Research Cancer Center of Montpellier, Val d'Aurelle Cancer Institute, Montpellier. Intraoperative radiotherapy given as a boost for early breast cancer: Long-term clinical and cosmetic results. United States. doi:10.1016/J.IJROBP.2005.1.
Lemanski, Claire, Azria, David, Thezenas, Simon, Gutowski, Marian, Saint-Aubert, Bernard, Rouanet, Philippe, Fenoglietto, Pascal, Ailleres, Norbert, Dubois, Jean-Bernard, and INSERM, Research Cancer Center of Montpellier, Val d'Aurelle Cancer Institute, Montpellier. Sat . "Intraoperative radiotherapy given as a boost for early breast cancer: Long-term clinical and cosmetic results". United States. doi:10.1016/J.IJROBP.2005.1.
@article{osti_20793426,
title = {Intraoperative radiotherapy given as a boost for early breast cancer: Long-term clinical and cosmetic results},
author = {Lemanski, Claire and Azria, David and Thezenas, Simon and Gutowski, Marian and Saint-Aubert, Bernard and Rouanet, Philippe and Fenoglietto, Pascal and Ailleres, Norbert and Dubois, Jean-Bernard and INSERM, Research Cancer Center of Montpellier, Val d'Aurelle Cancer Institute, Montpellier},
abstractNote = {Purpose: The standard radiotherapy (RT) of breast cancer consists of 50 Gy external beam RT (EBRT) to the whole breast followed by an electron boost of 10-16 Gy to the tumor bed, but this has several cosmetic disadvantages. Intraoperative radiotherapy (IORT) could be an alternative to overcome these. Methods and Materials: We evaluated 50 women with early breast cancer operated on in a dedicated IORT facility. Median dose of 10 Gy was delivered using 9-MeV electron beams. All patients received postoperative EBRT (50 Gy in 2 Gy fractions). Late toxicity and cosmetic results were assessed independently by two physicians according to the Common Terminology Criteria for Adverse Event v3.0 grading system and the European Organization for Research and Treatment of Cancer questionnaires. Results: After a median follow-up of 9.1 years (range, 5-15 years), two local recurrences were observed within the primary tumor bed. At the time of analysis, 45 patients are alive with (n = 1) or without disease. Among the 42 disease-free remaining patients, 6 experienced Grade 2 late subcutaneous fibrosis within the boost area. Overall, the scores indicated a very good quality of life and cosmesis was good to excellent in the evaluated patients. Conclusion: Our results confirm that IORT given as a boost after breast-conserving surgery is a reliable alternative to conventional postoperative fractionated boost radiation.},
doi = {10.1016/J.IJROBP.2005.1},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 64,
place = {United States},
year = {Sat Apr 01 00:00:00 EST 2006},
month = {Sat Apr 01 00:00:00 EST 2006}
}