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Title: Role of intracanalicular volumetric and dosimetric parameters on hearing preservation after vestibular schwannoma radiosurgery

Abstract

Purpose: To analyze the relationship between hearing preservation after gamma knife radiosurgery (GKR) for vestibular schwannoma (VS) and some volumetric and dosimetric parameters of the intracanalicular components of VS. Methods and Materials: This study included 82 patients with a VS treated by GKR; all patients had no NF2 disease, a Gardner-Robertson hearing class 1-4 before treatment, a marginal dose of 12 Gy, and a radiologic and audiologic follow-up {>=}1 year post-GKR. The volume of both the entire tumor and the intracanalicular part of the tumor and the mean and integrated dose of these two volumes were correlated to the auditory outcomes of patients. Results: At last hearing follow-up, 52 patients had no hearing worsening, and 30 patients had an increase of {>=}1 class on Gardner-Robertson classification. We found that hearing preservation after GKR is significantly correlated with the intracanalicular tumor volume, as well as with the integrated dose delivered to the intracanalicular tumor volume. Conclusions: Some volumetric and dosimetric parameters of the intracanalicular part of the tumor influence hearing preservation after GKR of VS. Consequently, we advise the direct treatment of patients with preserved functional hearing and a VS including a small intracanalicular volume.

Authors:
 [1];  [2];  [3];  [2];  [4];  [2];  [2];  [4];  [2];  [3];  [2];  [2]
  1. Gamma Knife Center, Erasme Hospital, Universite Libre de Brixelles, Brussels (Belgium). E-mail: nmassage@ulb.ac.be
  2. Gamma Knife Center, Erasme Hospital, Universite Libre de Brixelles, Brussels (Belgium)
  3. Department of Ear, Nose, and Throat, Erasme Hospital, Universite Libre de Brixelles, Brussels (Belgium)
  4. (Belgium)
Publication Date:
OSTI Identifier:
20793415
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 64; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2005.10.030; PII: S0360-3016(05)02948-2; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AUDITORY ORGANS; CARCINOMAS; DOSIMETRY; PATIENTS; PRESERVATION; RADIOTHERAPY; SURGERY

Citation Formats

Massager, Nicolas, Nissim, Ouzi, Delbrouck, Carine, Devriendt, Daniel, Department of Radiation Therapy and Laboratory of Physics, Jules Bordet Institute, Universite Libre de Brixelles, Brussels, David, Philippe, Desmedt, Francoise, Department of Radiation Therapy and Laboratory of Physics, Jules Bordet Institute, Universite Libre de Brixelles, Brussels, Wikler, David, Hassid, Sergio, Brotchi, Jacques, and Levivier, Marc. Role of intracanalicular volumetric and dosimetric parameters on hearing preservation after vestibular schwannoma radiosurgery. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.1.
Massager, Nicolas, Nissim, Ouzi, Delbrouck, Carine, Devriendt, Daniel, Department of Radiation Therapy and Laboratory of Physics, Jules Bordet Institute, Universite Libre de Brixelles, Brussels, David, Philippe, Desmedt, Francoise, Department of Radiation Therapy and Laboratory of Physics, Jules Bordet Institute, Universite Libre de Brixelles, Brussels, Wikler, David, Hassid, Sergio, Brotchi, Jacques, & Levivier, Marc. Role of intracanalicular volumetric and dosimetric parameters on hearing preservation after vestibular schwannoma radiosurgery. United States. doi:10.1016/J.IJROBP.2005.1.
Massager, Nicolas, Nissim, Ouzi, Delbrouck, Carine, Devriendt, Daniel, Department of Radiation Therapy and Laboratory of Physics, Jules Bordet Institute, Universite Libre de Brixelles, Brussels, David, Philippe, Desmedt, Francoise, Department of Radiation Therapy and Laboratory of Physics, Jules Bordet Institute, Universite Libre de Brixelles, Brussels, Wikler, David, Hassid, Sergio, Brotchi, Jacques, and Levivier, Marc. Sat . "Role of intracanalicular volumetric and dosimetric parameters on hearing preservation after vestibular schwannoma radiosurgery". United States. doi:10.1016/J.IJROBP.2005.1.
@article{osti_20793415,
title = {Role of intracanalicular volumetric and dosimetric parameters on hearing preservation after vestibular schwannoma radiosurgery},
author = {Massager, Nicolas and Nissim, Ouzi and Delbrouck, Carine and Devriendt, Daniel and Department of Radiation Therapy and Laboratory of Physics, Jules Bordet Institute, Universite Libre de Brixelles, Brussels and David, Philippe and Desmedt, Francoise and Department of Radiation Therapy and Laboratory of Physics, Jules Bordet Institute, Universite Libre de Brixelles, Brussels and Wikler, David and Hassid, Sergio and Brotchi, Jacques and Levivier, Marc},
abstractNote = {Purpose: To analyze the relationship between hearing preservation after gamma knife radiosurgery (GKR) for vestibular schwannoma (VS) and some volumetric and dosimetric parameters of the intracanalicular components of VS. Methods and Materials: This study included 82 patients with a VS treated by GKR; all patients had no NF2 disease, a Gardner-Robertson hearing class 1-4 before treatment, a marginal dose of 12 Gy, and a radiologic and audiologic follow-up {>=}1 year post-GKR. The volume of both the entire tumor and the intracanalicular part of the tumor and the mean and integrated dose of these two volumes were correlated to the auditory outcomes of patients. Results: At last hearing follow-up, 52 patients had no hearing worsening, and 30 patients had an increase of {>=}1 class on Gardner-Robertson classification. We found that hearing preservation after GKR is significantly correlated with the intracanalicular tumor volume, as well as with the integrated dose delivered to the intracanalicular tumor volume. Conclusions: Some volumetric and dosimetric parameters of the intracanalicular part of the tumor influence hearing preservation after GKR of VS. Consequently, we advise the direct treatment of patients with preserved functional hearing and a VS including a small intracanalicular volume.},
doi = {10.1016/J.IJROBP.2005.1},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 64,
place = {United States},
year = {Sat Apr 01 00:00:00 EST 2006},
month = {Sat Apr 01 00:00:00 EST 2006}
}