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Title: Pretreatment photosensitizer dosimetry reduces variation in tumor response

Abstract

Purpose: To compensate for photosensitizer uptake variation in photodynamic therapy (PDT), via control of delivered light dose through photodynamic dose calculation based on online dosimetry of photosensitizer in tissue before treatment. Methods and Materials: Photosensitizer verteporfin was quantified via multiple fluorescence microprobe measurements immediately before treatment. To compensate individual PDT treatments, photodynamic doses were calculated on an individual animal basis, by matching the light delivered to provide an equal photosensitizer dose multiplied by light dose. This was completed for the lower quartile, median, and upper quartile of the photosensitizer distribution. PDT-induced tumor responses were evaluated by the tumor regrowth assay. Results: Verteporfin uptake varied considerably among tumors and within a tumor. The coefficient of variation in the surviving fraction was found significantly decreased in groups compensated to the lower quartile (CL-PDT), the median (CM-PDT), and the upper quartile (CU-PDT) of photosensitizer distribution. The CL-PDT group was significantly less effective compared with NC-PDT (Noncompensated PDT), CM-PDT, and CU-PDT treatments. No significant difference in effectiveness was observed between NC-PDT, CM-PDT, and CU-PDT treatment groups. Conclusions: This research suggests that accurate quantification of tissue photosensitizer levels and subsequent adjustment of light dose will allow for reduced subject variation and improved treatment consistency.

Authors:
 [1];  [2];  [1];  [3];  [4];  [1];  [1];  [3];  [5]
  1. Thayer School of Engineering, Dartmouth College, Hanover, NH (United States)
  2. Thayer School of Engineering, Dartmouth College, Hanover, NH (United States) and Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, Boston, MA (United States). E-mail: Brian.W.Pogue@Dartmouth.edu
  3. (United States)
  4. Section of Biostatistics and Epidemiology, Dartmouth Medical School, Hanover, NH (United States)
  5. Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Dermatology, Harvard Medical School, Boston, MA (United States)
Publication Date:
OSTI Identifier:
20793403
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 64; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2005.11.019; PII: S0360-3016(05)02955-X; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; DOSIMETRY; FLUORESCENCE; NEOPLASMS; PLANNING; RADIATION DOSES; RADIOTHERAPY; UPTAKE

Citation Formats

Zhou Xiaodong, Pogue, Brian W., Chen Bin, Department of Surgery, Dartmouth Medical School, Hanover, NH, Demidenko, Eugene, Joshi, Rohan, Hoopes, Jack, Department of Surgery, Dartmouth Medical School, Hanover, NH, and Hasan, Tayyaba. Pretreatment photosensitizer dosimetry reduces variation in tumor response. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.1.
Zhou Xiaodong, Pogue, Brian W., Chen Bin, Department of Surgery, Dartmouth Medical School, Hanover, NH, Demidenko, Eugene, Joshi, Rohan, Hoopes, Jack, Department of Surgery, Dartmouth Medical School, Hanover, NH, & Hasan, Tayyaba. Pretreatment photosensitizer dosimetry reduces variation in tumor response. United States. doi:10.1016/J.IJROBP.2005.1.
Zhou Xiaodong, Pogue, Brian W., Chen Bin, Department of Surgery, Dartmouth Medical School, Hanover, NH, Demidenko, Eugene, Joshi, Rohan, Hoopes, Jack, Department of Surgery, Dartmouth Medical School, Hanover, NH, and Hasan, Tayyaba. Wed . "Pretreatment photosensitizer dosimetry reduces variation in tumor response". United States. doi:10.1016/J.IJROBP.2005.1.
@article{osti_20793403,
title = {Pretreatment photosensitizer dosimetry reduces variation in tumor response},
author = {Zhou Xiaodong and Pogue, Brian W. and Chen Bin and Department of Surgery, Dartmouth Medical School, Hanover, NH and Demidenko, Eugene and Joshi, Rohan and Hoopes, Jack and Department of Surgery, Dartmouth Medical School, Hanover, NH and Hasan, Tayyaba},
abstractNote = {Purpose: To compensate for photosensitizer uptake variation in photodynamic therapy (PDT), via control of delivered light dose through photodynamic dose calculation based on online dosimetry of photosensitizer in tissue before treatment. Methods and Materials: Photosensitizer verteporfin was quantified via multiple fluorescence microprobe measurements immediately before treatment. To compensate individual PDT treatments, photodynamic doses were calculated on an individual animal basis, by matching the light delivered to provide an equal photosensitizer dose multiplied by light dose. This was completed for the lower quartile, median, and upper quartile of the photosensitizer distribution. PDT-induced tumor responses were evaluated by the tumor regrowth assay. Results: Verteporfin uptake varied considerably among tumors and within a tumor. The coefficient of variation in the surviving fraction was found significantly decreased in groups compensated to the lower quartile (CL-PDT), the median (CM-PDT), and the upper quartile (CU-PDT) of photosensitizer distribution. The CL-PDT group was significantly less effective compared with NC-PDT (Noncompensated PDT), CM-PDT, and CU-PDT treatments. No significant difference in effectiveness was observed between NC-PDT, CM-PDT, and CU-PDT treatment groups. Conclusions: This research suggests that accurate quantification of tissue photosensitizer levels and subsequent adjustment of light dose will allow for reduced subject variation and improved treatment consistency.},
doi = {10.1016/J.IJROBP.2005.1},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 4,
volume = 64,
place = {United States},
year = {Wed Mar 15 00:00:00 EST 2006},
month = {Wed Mar 15 00:00:00 EST 2006}
}