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Title: X-ray volume imaging in bladder radiotherapy verification

Abstract

Purpose: To assess the clinical utility of X-ray volume imaging (XVI) for verification of bladder radiotherapy and to quantify geometric error in bladder radiotherapy delivery. Methods and Materials: Twenty subjects undergoing conformal bladder radiotherapy were recruited. X-ray volume images and electronic portal images (EPIs) were acquired for the first 5 fractions and then once weekly. X-ray volume images were co-registered with the planning computed tomography scan and clinical target volume coverage assessed in three dimensions (3D). Interfraction bladder volume change was described by quantifying changes in bladder volume with time. Bony setup errors were compared from both XVI and EPI. Results: The bladder boundary was clearly visible on coronal XVI views in nearly all images, allowing accurate 3D treatment verification. In 93.5% of imaged fractions, the clinical target volume was within the planning target volume. Most subjects displayed consistent bladder volumes, but 25% displayed changes that could be predicted from the first three XVIs. Bony setup errors were similar whether calculated from XVI or EPI. Conclusions: Coronal XVI can be used to verify 3D bladder radiotherapy delivery. Image-guided interventions to reduce geographic miss and normal tissue toxicity are feasible with this technology.

Authors:
 [1];  [2];  [2];  [2];  [3];  [3];  [3];  [4];  [4];  [4];  [4];  [5];  [3];  [5]
  1. Academic Department of Radiation Oncology, University of Manchester, Manchester (United Kingdom). E-mail: amhenry@doctors.net.uk
  2. Wade Centre for Radiotherapy Research, Christie Hospital NHS Trust, Manchester (United Kingdom)
  3. Developing Technology Group, North Western Medical Physics, Manchester (United Kingdom)
  4. Department of Clinical Oncology, Christie Hospital NHS Trust, Manchester (United Kingdom)
  5. Academic Department of Radiation Oncology, University of Manchester, Manchester (United Kingdom)
Publication Date:
OSTI Identifier:
20793397
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 64; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2005.09.044; PII: S0360-3016(05)02730-6; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLADDER; CARCINOMAS; COMPUTERIZED TOMOGRAPHY; ERRORS; IMAGES; RADIOTHERAPY; TOXICITY; VERIFICATION; X RADIATION

Citation Formats

Henry, Ann M., Stratford, Julia, McCarthy, Claire, Davies, Julie, Sykes, Jonathan R., Amer, Ali, Marchant, Tom, Cowan, Richard, Wylie, James, Logue, John, Livsey, Jacqueline, Khoo, Vincent S., Moore, Chris, and Price, Pat. X-ray volume imaging in bladder radiotherapy verification. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.0.
Henry, Ann M., Stratford, Julia, McCarthy, Claire, Davies, Julie, Sykes, Jonathan R., Amer, Ali, Marchant, Tom, Cowan, Richard, Wylie, James, Logue, John, Livsey, Jacqueline, Khoo, Vincent S., Moore, Chris, & Price, Pat. X-ray volume imaging in bladder radiotherapy verification. United States. doi:10.1016/J.IJROBP.2005.0.
Henry, Ann M., Stratford, Julia, McCarthy, Claire, Davies, Julie, Sykes, Jonathan R., Amer, Ali, Marchant, Tom, Cowan, Richard, Wylie, James, Logue, John, Livsey, Jacqueline, Khoo, Vincent S., Moore, Chris, and Price, Pat. Wed . "X-ray volume imaging in bladder radiotherapy verification". United States. doi:10.1016/J.IJROBP.2005.0.
@article{osti_20793397,
title = {X-ray volume imaging in bladder radiotherapy verification},
author = {Henry, Ann M. and Stratford, Julia and McCarthy, Claire and Davies, Julie and Sykes, Jonathan R. and Amer, Ali and Marchant, Tom and Cowan, Richard and Wylie, James and Logue, John and Livsey, Jacqueline and Khoo, Vincent S. and Moore, Chris and Price, Pat},
abstractNote = {Purpose: To assess the clinical utility of X-ray volume imaging (XVI) for verification of bladder radiotherapy and to quantify geometric error in bladder radiotherapy delivery. Methods and Materials: Twenty subjects undergoing conformal bladder radiotherapy were recruited. X-ray volume images and electronic portal images (EPIs) were acquired for the first 5 fractions and then once weekly. X-ray volume images were co-registered with the planning computed tomography scan and clinical target volume coverage assessed in three dimensions (3D). Interfraction bladder volume change was described by quantifying changes in bladder volume with time. Bony setup errors were compared from both XVI and EPI. Results: The bladder boundary was clearly visible on coronal XVI views in nearly all images, allowing accurate 3D treatment verification. In 93.5% of imaged fractions, the clinical target volume was within the planning target volume. Most subjects displayed consistent bladder volumes, but 25% displayed changes that could be predicted from the first three XVIs. Bony setup errors were similar whether calculated from XVI or EPI. Conclusions: Coronal XVI can be used to verify 3D bladder radiotherapy delivery. Image-guided interventions to reduce geographic miss and normal tissue toxicity are feasible with this technology.},
doi = {10.1016/J.IJROBP.2005.0},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 4,
volume = 64,
place = {United States},
year = {Wed Mar 15 00:00:00 EST 2006},
month = {Wed Mar 15 00:00:00 EST 2006}
}