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Title: Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation

Abstract

Purpose: Several accelerated partial-breast irradiation (APBI) techniques are being investigated in patients with early-stage breast cancer. We present our initial experience using three-dimensional conformal radiation therapy (3D-CRT). Methods and Materials: Sixty-one patients with tumors of 2 cm or less and negative axillary nodes were treated with 3D-CRT accelerated partial-breast irradiation (APBI) between August 2003 and March 2005. The prescribed radiation dose was 32 Gy in 4-Gy fractions given twice daily. Efforts were made to minimize the number of beams required to achieve adequate planning target volume (PTV) coverage. Results: A combination of photons and electrons was used in 85% of patients. A three-field technique that consisted of opposed, conformal tangential photons and enface electrons was employed in 43 patients (70%). Nine patients (15%) were treated with a four-field arrangement, which consisted of three photon fields and enface electrons. Mean PTV volumes that received 100%, 95%, and 90% of the prescribed dose were 93% {+-} 7%, 97% {+-} 4%, and 98% {+-} 2%, respectively. Dose inhomogeneity exceeded 10% in only 7 patients (11%). Mean doses to the ipsilateral lung and heart were 1.8 Gy and 0.8 Gy, respectively. Conclusions: Simple 3D-CRT techniques of APBI can achieve appropriate PTV coverage while offeringmore » significant normal-tissue sparing. Therefore, this noninvasive approach may increase the availability of APBI to patients with early-stage breast cancer.« less

Authors:
 [1];  [2];  [2];  [2];  [3];  [3];  [3];  [3];  [4];  [5];  [6];  [2]
  1. Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States). E-mail: ataghian@partners.org
  2. Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA (United States)
  3. Department of Surgical Oncology, Massachusetts General Hospital, Boston, MA (United States)
  4. Department of Breast Pathology, Massachusetts General Hospital, Boston, MA (United States)
  5. Department of Radiation Oncology, Boston Medical Center, Boston, MA (United States)
  6. Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA (United States)
Publication Date:
OSTI Identifier:
20793387
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 64; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2005.09.042; PII: S0360-3016(05)02722-7; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ELECTRONS; HEART; IRRADIATION; LUNGS; MAMMARY GLANDS; NEOPLASMS; PATIENTS; PHOTONS; RADIATION DOSES; RADIOTHERAPY

Citation Formats

Taghian, Alphonse G., Kozak, Kevin R., Doppke, Karen P., Katz, Angela, Smith, Barbara L., Gadd, Michele, Specht, Michelle, Hughes, Kevin, Braaten, Kristina, Kachnic, Lisa A., Recht, Abram, and Powell, Simon N.. Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.0.
Taghian, Alphonse G., Kozak, Kevin R., Doppke, Karen P., Katz, Angela, Smith, Barbara L., Gadd, Michele, Specht, Michelle, Hughes, Kevin, Braaten, Kristina, Kachnic, Lisa A., Recht, Abram, & Powell, Simon N.. Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation. United States. doi:10.1016/J.IJROBP.2005.0.
Taghian, Alphonse G., Kozak, Kevin R., Doppke, Karen P., Katz, Angela, Smith, Barbara L., Gadd, Michele, Specht, Michelle, Hughes, Kevin, Braaten, Kristina, Kachnic, Lisa A., Recht, Abram, and Powell, Simon N.. Wed . "Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation". United States. doi:10.1016/J.IJROBP.2005.0.
@article{osti_20793387,
title = {Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation},
author = {Taghian, Alphonse G. and Kozak, Kevin R. and Doppke, Karen P. and Katz, Angela and Smith, Barbara L. and Gadd, Michele and Specht, Michelle and Hughes, Kevin and Braaten, Kristina and Kachnic, Lisa A. and Recht, Abram and Powell, Simon N.},
abstractNote = {Purpose: Several accelerated partial-breast irradiation (APBI) techniques are being investigated in patients with early-stage breast cancer. We present our initial experience using three-dimensional conformal radiation therapy (3D-CRT). Methods and Materials: Sixty-one patients with tumors of 2 cm or less and negative axillary nodes were treated with 3D-CRT accelerated partial-breast irradiation (APBI) between August 2003 and March 2005. The prescribed radiation dose was 32 Gy in 4-Gy fractions given twice daily. Efforts were made to minimize the number of beams required to achieve adequate planning target volume (PTV) coverage. Results: A combination of photons and electrons was used in 85% of patients. A three-field technique that consisted of opposed, conformal tangential photons and enface electrons was employed in 43 patients (70%). Nine patients (15%) were treated with a four-field arrangement, which consisted of three photon fields and enface electrons. Mean PTV volumes that received 100%, 95%, and 90% of the prescribed dose were 93% {+-} 7%, 97% {+-} 4%, and 98% {+-} 2%, respectively. Dose inhomogeneity exceeded 10% in only 7 patients (11%). Mean doses to the ipsilateral lung and heart were 1.8 Gy and 0.8 Gy, respectively. Conclusions: Simple 3D-CRT techniques of APBI can achieve appropriate PTV coverage while offering significant normal-tissue sparing. Therefore, this noninvasive approach may increase the availability of APBI to patients with early-stage breast cancer.},
doi = {10.1016/J.IJROBP.2005.0},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 4,
volume = 64,
place = {United States},
year = {Wed Mar 15 00:00:00 EST 2006},
month = {Wed Mar 15 00:00:00 EST 2006}
}