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Title: Spinal cord gliomas: A multi-institutional retrospective analysis

Abstract

Purpose: To determine the impact of postoperative radiation therapy (POXRT) on outcome in spinal cord gliomas. Patients and Methods: Data from 242 patients were collected retrospectively from six institutions using a standardized data sheet. Pathology specimens, when available, were centrally reviewed. Results: A total of 183 patients were analyzed: 82 received surgery alone as initial treatment, whereas 101 had surgery and POXRT. Demographic, diagnostic, and treatment factors were analyzed for impact on progression-free (PFS) and overall survival (OS). PFS in ependymoma patients was 74%, 60%, and 35% at 5, 10, 15 years, respectively, and was significantly influenced by treatment type, race, age, tumor grade, and type of surgery on univariate analysis, with age being the only significant factor on multivariate analysis (MVA) (p = 0.01). OS of ependymoma patients was 91%, 84%, and 75% at 5, 10, and 15 years, respectively, and was significantly influenced by both complete resection (p = 0.04) and age (p = 0.03) on MVA. In astrocytomas, PFS was 42%, 29%, and 15% at 5, 10, and 15 years, and was significantly influenced by POXRT in low- and intermediate-grade tumors on MVA (p = 0.02). OS at 5, 10, and 15 years was 59%, 53%, andmore » 32%, respectively, and was significantly influenced by grade on MVA (p < 0.01). Conclusion: Postoperative radiation therapy reduced disease progression in low- and moderate-grade astrocytomas. In ependymomas, complete resection significantly influenced OS.« less

Authors:
 [1];  [2];  [3];  [4];  [5];  [6];  [7];  [8];  [3];  [9];  [10];  [5];  [2]
  1. Department of Radiation Oncology, University of Miami, Miami, FL (United States). E-mail: mwahab@med.miami.edu
  2. Department of Radiation Oncology, University of Miami, Miami, FL (United States)
  3. Department of Radiation Oncology, Wake Forest University School of Medicine, Wake Forest, NC (United States)
  4. Department of Radiation Oncology, Hokkaido University, Hokkaido (Japan)
  5. Department of Radiation Oncology, Arizona Oncology Services at St Joseph's Hospital and Medical Center, and Cyberknife Center, Barrow Neurologic Institute, Phoenix, AZ (United States)
  6. Department of Pathology, Anadolu Health Care System, Kocaeli (Turkey)
  7. University of Miami/Sylvester Comprehensive Cancer Center, Division of Biostatistics, Miami, FL (United States)
  8. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN (United States)
  9. Department of Radiation Oncology, Wayne State University, Detroit, MI (United States)
  10. Department of Radiation Oncology, Thomas Jefferson University, Philadelphia, PA (United States)
Publication Date:
OSTI Identifier:
20793384
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 64; Journal Issue: 4; Other Information: DOI: 10.1016/j.ijrobp.2005.09.038; PII: S0360-3016(05)02708-2; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ASTROCYTOMAS; MULTIVARIATE ANALYSIS; PATHOLOGY; PATIENTS; RADIOTHERAPY; SPINAL CORD; SURGERY

Citation Formats

Abdel-Wahab, May, Etuk, Blessing, Palermo, James, Shirato, Hiroki, Kresl, John, Yapicier, Ozlem, Walker, Gail, Scheithauer, Bernd W., Shaw, Edward, Lee, Charles, Curran, Walter, Thomas, Terry, and Markoe, Arnold. Spinal cord gliomas: A multi-institutional retrospective analysis. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.0.
Abdel-Wahab, May, Etuk, Blessing, Palermo, James, Shirato, Hiroki, Kresl, John, Yapicier, Ozlem, Walker, Gail, Scheithauer, Bernd W., Shaw, Edward, Lee, Charles, Curran, Walter, Thomas, Terry, & Markoe, Arnold. Spinal cord gliomas: A multi-institutional retrospective analysis. United States. doi:10.1016/J.IJROBP.2005.0.
Abdel-Wahab, May, Etuk, Blessing, Palermo, James, Shirato, Hiroki, Kresl, John, Yapicier, Ozlem, Walker, Gail, Scheithauer, Bernd W., Shaw, Edward, Lee, Charles, Curran, Walter, Thomas, Terry, and Markoe, Arnold. Wed . "Spinal cord gliomas: A multi-institutional retrospective analysis". United States. doi:10.1016/J.IJROBP.2005.0.
@article{osti_20793384,
title = {Spinal cord gliomas: A multi-institutional retrospective analysis},
author = {Abdel-Wahab, May and Etuk, Blessing and Palermo, James and Shirato, Hiroki and Kresl, John and Yapicier, Ozlem and Walker, Gail and Scheithauer, Bernd W. and Shaw, Edward and Lee, Charles and Curran, Walter and Thomas, Terry and Markoe, Arnold},
abstractNote = {Purpose: To determine the impact of postoperative radiation therapy (POXRT) on outcome in spinal cord gliomas. Patients and Methods: Data from 242 patients were collected retrospectively from six institutions using a standardized data sheet. Pathology specimens, when available, were centrally reviewed. Results: A total of 183 patients were analyzed: 82 received surgery alone as initial treatment, whereas 101 had surgery and POXRT. Demographic, diagnostic, and treatment factors were analyzed for impact on progression-free (PFS) and overall survival (OS). PFS in ependymoma patients was 74%, 60%, and 35% at 5, 10, 15 years, respectively, and was significantly influenced by treatment type, race, age, tumor grade, and type of surgery on univariate analysis, with age being the only significant factor on multivariate analysis (MVA) (p = 0.01). OS of ependymoma patients was 91%, 84%, and 75% at 5, 10, and 15 years, respectively, and was significantly influenced by both complete resection (p = 0.04) and age (p = 0.03) on MVA. In astrocytomas, PFS was 42%, 29%, and 15% at 5, 10, and 15 years, and was significantly influenced by POXRT in low- and intermediate-grade tumors on MVA (p = 0.02). OS at 5, 10, and 15 years was 59%, 53%, and 32%, respectively, and was significantly influenced by grade on MVA (p < 0.01). Conclusion: Postoperative radiation therapy reduced disease progression in low- and moderate-grade astrocytomas. In ependymomas, complete resection significantly influenced OS.},
doi = {10.1016/J.IJROBP.2005.0},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 4,
volume = 64,
place = {United States},
year = {Wed Mar 15 00:00:00 EST 2006},
month = {Wed Mar 15 00:00:00 EST 2006}
}