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Title: Integral radiation dose to normal structures with conformal external beam radiation

Abstract

Background: This study was designed to evaluate the integral dose (ID) received by normal tissue from intensity-modulated radiotherapy (IMRT) for prostate cancer. Methods and Materials: Twenty-five radiation treatment plans including IMRT using a conventional linac with both 6 MV (6MV-IMRT) and 20 MV (20MV-IMRT), as well as three-dimensional conformal radiotherapy (3DCRT) using 6 MV (6MV-3DCRT) and 20 MV (20MV-3DCRT) and IMRT using tomotherapy (6MV) (Tomo-IMRT), were created for 5 patients with localized prostate cancer. The ID (mean dose x tissue volume) received by normal tissue (NTID) was calculated from dose-volume histograms. Results: The 6MV-IMRT resulted in 5.0% lower NTID than 6MV-3DCRT; 20 MV beam plans resulted in 7.7%-11.2% lower NTID than 6MV-3DCRT. Tomo-IMRT NTID was comparable to 6MV-IMRT. Compared with 6MV-3DCRT, 6MV-IMRT reduced IDs to the rectal wall and penile bulb by 6.1% and 2.7%, respectively. Tomo-IMRT further reduced these IDs by 11.9% and 16.5%, respectively. The 20 MV did not reduce IDs to those structures. Conclusions: The difference in NTID between 3DCRT and IMRT is small. The 20 MV plans somewhat reduced NTID compared with 6 MV plans. The advantage of tomotherapy over conventional IMRT and 3DCRT for localized prostate cancer was demonstrated in regard to dose sparing ofmore » rectal wall and penile bulb while slightly decreasing NTID as compared with 6MV-3DCRT.« less

Authors:
 [1];  [2];  [3];  [4];  [4];  [2];  [4];  [3];  [4];  [3];  [3];  [3];  [4];  [3];  [3]
  1. Department of Human Oncology, University of Wisconsin, Madison, WI (United States) and Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo (Japan). E-mail: hao@radi.med.hokudai.ac.jp
  2. Department of Medical Physics, University of Wisconsin, Madison, WI (United States)
  3. Department of Human Oncology, University of Wisconsin, Madison, WI (United States)
  4. (United States)
Publication Date:
OSTI Identifier:
20793371
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 64; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2005.11.005; PII: S0360-3016(05)02946-9; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BEAMS; CARCINOMAS; COMPUTERIZED TOMOGRAPHY; INTEGRAL DOSES; LINEAR ACCELERATORS; PATIENTS; PROSTATE; RADIOTHERAPY

Citation Formats

Aoyama, Hidefumi, Westerly, David Clark, Mackie, Thomas Rockwell, Department of Medical Physics, University of Wisconsin, Madison, WI, TomoTherapy Inc., Madison, WI, Olivera, Gustavo H., TomoTherapy Inc., Madison, WI, Bentzen, Soren M., Department of Medical Physics, University of Wisconsin, Madison, WI, Patel, Rakesh R., Jaradat, Hazim, Tome, Wolfgang A., Department of Medical Physics, University of Wisconsin, Madison, WI, Ritter, Mark A., and Mehta, Minesh P. Integral radiation dose to normal structures with conformal external beam radiation. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.1.
Aoyama, Hidefumi, Westerly, David Clark, Mackie, Thomas Rockwell, Department of Medical Physics, University of Wisconsin, Madison, WI, TomoTherapy Inc., Madison, WI, Olivera, Gustavo H., TomoTherapy Inc., Madison, WI, Bentzen, Soren M., Department of Medical Physics, University of Wisconsin, Madison, WI, Patel, Rakesh R., Jaradat, Hazim, Tome, Wolfgang A., Department of Medical Physics, University of Wisconsin, Madison, WI, Ritter, Mark A., & Mehta, Minesh P. Integral radiation dose to normal structures with conformal external beam radiation. United States. doi:10.1016/J.IJROBP.2005.1.
Aoyama, Hidefumi, Westerly, David Clark, Mackie, Thomas Rockwell, Department of Medical Physics, University of Wisconsin, Madison, WI, TomoTherapy Inc., Madison, WI, Olivera, Gustavo H., TomoTherapy Inc., Madison, WI, Bentzen, Soren M., Department of Medical Physics, University of Wisconsin, Madison, WI, Patel, Rakesh R., Jaradat, Hazim, Tome, Wolfgang A., Department of Medical Physics, University of Wisconsin, Madison, WI, Ritter, Mark A., and Mehta, Minesh P. Wed . "Integral radiation dose to normal structures with conformal external beam radiation". United States. doi:10.1016/J.IJROBP.2005.1.
@article{osti_20793371,
title = {Integral radiation dose to normal structures with conformal external beam radiation},
author = {Aoyama, Hidefumi and Westerly, David Clark and Mackie, Thomas Rockwell and Department of Medical Physics, University of Wisconsin, Madison, WI and TomoTherapy Inc., Madison, WI and Olivera, Gustavo H. and TomoTherapy Inc., Madison, WI and Bentzen, Soren M. and Department of Medical Physics, University of Wisconsin, Madison, WI and Patel, Rakesh R. and Jaradat, Hazim and Tome, Wolfgang A. and Department of Medical Physics, University of Wisconsin, Madison, WI and Ritter, Mark A. and Mehta, Minesh P.},
abstractNote = {Background: This study was designed to evaluate the integral dose (ID) received by normal tissue from intensity-modulated radiotherapy (IMRT) for prostate cancer. Methods and Materials: Twenty-five radiation treatment plans including IMRT using a conventional linac with both 6 MV (6MV-IMRT) and 20 MV (20MV-IMRT), as well as three-dimensional conformal radiotherapy (3DCRT) using 6 MV (6MV-3DCRT) and 20 MV (20MV-3DCRT) and IMRT using tomotherapy (6MV) (Tomo-IMRT), were created for 5 patients with localized prostate cancer. The ID (mean dose x tissue volume) received by normal tissue (NTID) was calculated from dose-volume histograms. Results: The 6MV-IMRT resulted in 5.0% lower NTID than 6MV-3DCRT; 20 MV beam plans resulted in 7.7%-11.2% lower NTID than 6MV-3DCRT. Tomo-IMRT NTID was comparable to 6MV-IMRT. Compared with 6MV-3DCRT, 6MV-IMRT reduced IDs to the rectal wall and penile bulb by 6.1% and 2.7%, respectively. Tomo-IMRT further reduced these IDs by 11.9% and 16.5%, respectively. The 20 MV did not reduce IDs to those structures. Conclusions: The difference in NTID between 3DCRT and IMRT is small. The 20 MV plans somewhat reduced NTID compared with 6 MV plans. The advantage of tomotherapy over conventional IMRT and 3DCRT for localized prostate cancer was demonstrated in regard to dose sparing of rectal wall and penile bulb while slightly decreasing NTID as compared with 6MV-3DCRT.},
doi = {10.1016/J.IJROBP.2005.1},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 3,
volume = 64,
place = {United States},
year = {Wed Mar 01 00:00:00 EST 2006},
month = {Wed Mar 01 00:00:00 EST 2006}
}