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Title: Clinical investigation survival prediction in high-grade gliomas by MRI perfusion before and during early stage of RT

Abstract

Purpose: To determine whether cerebral blood volume (CBV) and cerebral blood flow can predict the response of high-grade gliomas to radiotherapy (RT) by taking into account spatial heterogeneity and temporal changes in perfusion. Methods and Materials: Twenty-three patients with high-grade gliomas underwent conformal RT, with magnetic resonance imaging perfusion before and at Weeks 1-2 and 3-4 during RT. Tumor perfusion was classified as high, medium, or low. The prognostic values of pre-RT perfusion and the changes during RT for early prediction of tumor response to RT were evaluated. Results: The fractional high-CBV tumor volume before RT and the fluid-attenuated inversion recovery imaging tumor volume were identified as predictors for survival (p = 0.01). Changes in tumor CBV during the early treatment course also predicted for survival. Better survival was predicted by a decrease in the fractional low-CBV tumor volume at Week 1 of RT vs. before RT, a decrease in the fractional high-CBV tumor volume at Week 3 vs. Week 1 of RT, and a smaller pre-RT fluid-attenuated inversion recovery imaging tumor volume (p = 0.01). Conclusion: Early temporal changes during RT in heterogeneous regions of high and low perfusion in gliomas might predict for different physiologic responses to RT.more » This might also open the opportunity to identify tumor subvolumes that are radioresistant and might benefit from intensified RT.« less

Authors:
 [1];  [2];  [2];  [3];  [2];  [4];  [4];  [2]
  1. Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States) and Department of Radiology, University of Michigan, Ann Arbor, MI (United States). E-mail: yuecao@med.umich.edu
  2. Department of Radiation Oncology, University of Michigan, Ann Arbor, MI (United States)
  3. Department of Neurology, University of Michigan, Ann Arbor, MI (United States)
  4. Department of Radiology, University of Michigan, Ann Arbor, MI (United States)
Publication Date:
OSTI Identifier:
20793359
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 64; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2005.09.001; PII: S0360-3016(05)02592-7; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD; BLOOD FLOW; FORECASTING; GLIOMAS; NMR IMAGING; PATIENTS; RADIOTHERAPY

Citation Formats

Cao Yue, Tsien, Christina I., Nagesh, Vijaya, Junck, Larry, Haken, Randall ten, Ross, Brian D., Chenevert, Thomas L., and Lawrence, Theodore S.. Clinical investigation survival prediction in high-grade gliomas by MRI perfusion before and during early stage of RT. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.0.
Cao Yue, Tsien, Christina I., Nagesh, Vijaya, Junck, Larry, Haken, Randall ten, Ross, Brian D., Chenevert, Thomas L., & Lawrence, Theodore S.. Clinical investigation survival prediction in high-grade gliomas by MRI perfusion before and during early stage of RT. United States. doi:10.1016/J.IJROBP.2005.0.
Cao Yue, Tsien, Christina I., Nagesh, Vijaya, Junck, Larry, Haken, Randall ten, Ross, Brian D., Chenevert, Thomas L., and Lawrence, Theodore S.. Wed . "Clinical investigation survival prediction in high-grade gliomas by MRI perfusion before and during early stage of RT". United States. doi:10.1016/J.IJROBP.2005.0.
@article{osti_20793359,
title = {Clinical investigation survival prediction in high-grade gliomas by MRI perfusion before and during early stage of RT},
author = {Cao Yue and Tsien, Christina I. and Nagesh, Vijaya and Junck, Larry and Haken, Randall ten and Ross, Brian D. and Chenevert, Thomas L. and Lawrence, Theodore S.},
abstractNote = {Purpose: To determine whether cerebral blood volume (CBV) and cerebral blood flow can predict the response of high-grade gliomas to radiotherapy (RT) by taking into account spatial heterogeneity and temporal changes in perfusion. Methods and Materials: Twenty-three patients with high-grade gliomas underwent conformal RT, with magnetic resonance imaging perfusion before and at Weeks 1-2 and 3-4 during RT. Tumor perfusion was classified as high, medium, or low. The prognostic values of pre-RT perfusion and the changes during RT for early prediction of tumor response to RT were evaluated. Results: The fractional high-CBV tumor volume before RT and the fluid-attenuated inversion recovery imaging tumor volume were identified as predictors for survival (p = 0.01). Changes in tumor CBV during the early treatment course also predicted for survival. Better survival was predicted by a decrease in the fractional low-CBV tumor volume at Week 1 of RT vs. before RT, a decrease in the fractional high-CBV tumor volume at Week 3 vs. Week 1 of RT, and a smaller pre-RT fluid-attenuated inversion recovery imaging tumor volume (p = 0.01). Conclusion: Early temporal changes during RT in heterogeneous regions of high and low perfusion in gliomas might predict for different physiologic responses to RT. This might also open the opportunity to identify tumor subvolumes that are radioresistant and might benefit from intensified RT.},
doi = {10.1016/J.IJROBP.2005.0},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 3,
volume = 64,
place = {United States},
year = {Wed Mar 01 00:00:00 EST 2006},
month = {Wed Mar 01 00:00:00 EST 2006}
}