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Title: Eleven-year follow-up results in the delay of breast irradiation after conservative breast surgery in node-negative breast cancer patients

Abstract

Purpose: This retrospective review was conducted to determine if delay in the start of radiotherapy after conservative breast surgery had any detrimental effect on local recurrence or disease-free survival in node-negative breast cancer patients. Methods and Materials: A total of 568 patients with T1 and T2, N0 breast cancer were treated with breast-conserving surgery and breast irradiation, without adjuvant systemic therapy, between January 1, 1985 and December 31, 1992 at the London Regional Cancer Centre. The time intervals from definitive breast surgery to breast irradiation used for analysis were 0 to 8 weeks (201 patients), greater than 8 to 12 weeks (235 patients), greater than 12 to 16 weeks (91 patients), and greater than 16 weeks (41 patients). Kaplan-Meier estimates of time to local-recurrence and disease-free survival rates were calculated. Results: Median follow-up was 11.2 years. Patients in all 4 time intervals were similar in terms of age and pathologic features. No statistically significant difference was seen between the 4 groups in local recurrence or disease-free survival with surgery radiotherapy interval (p = 0.521 and p = 0.222, respectively). The overall local-recurrence rate at 5 and 10 years was 4.6% and 11.3%, respectively. The overall disease-free survival at 5 andmore » 10 years was 79.6% and 67.0%, respectively. Conclusion: This retrospective study suggests that delay in the start of breast irradiation of up to 16 weeks from definitive surgery does not increase the risk of recurrence in node-negative breast cancer patients. The certainty of these results is limited by the retrospective nature of this analysis.« less

Authors:
 [1];  [2];  [3];  [2];  [4];  [2]
  1. Department of Radiation Oncology, London Regional Cancer Centre, London, Ontario (Canada). E-mail: olga.vujovic@lhsc.on.ca
  2. Department of Radiation Oncology, London Regional Cancer Centre, London, Ontario (Canada)
  3. Department of Medical Oncology, London Regional Cancer Centre, London, Ontario (Canada)
  4. Clinical Research Unit, London Regional Cancer Centre, London, Ontario (Canada)
Publication Date:
OSTI Identifier:
20793342
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 64; Journal Issue: 3; Other Information: DOI: 10.1016/j.ijrobp.2005.08.004; PII: S0360-3016(05)02363-1; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; IRRADIATION; MAMMARY GLANDS; PATIENTS; RADIOTHERAPY; REVIEWS; SURGERY

Citation Formats

Vujovic, Olga, Yu, Edward, Cherian, Anil, Dar, A. Rashid, Stitt, Larry, and Perera, Francisco. Eleven-year follow-up results in the delay of breast irradiation after conservative breast surgery in node-negative breast cancer patients. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.0.
Vujovic, Olga, Yu, Edward, Cherian, Anil, Dar, A. Rashid, Stitt, Larry, & Perera, Francisco. Eleven-year follow-up results in the delay of breast irradiation after conservative breast surgery in node-negative breast cancer patients. United States. doi:10.1016/J.IJROBP.2005.0.
Vujovic, Olga, Yu, Edward, Cherian, Anil, Dar, A. Rashid, Stitt, Larry, and Perera, Francisco. Wed . "Eleven-year follow-up results in the delay of breast irradiation after conservative breast surgery in node-negative breast cancer patients". United States. doi:10.1016/J.IJROBP.2005.0.
@article{osti_20793342,
title = {Eleven-year follow-up results in the delay of breast irradiation after conservative breast surgery in node-negative breast cancer patients},
author = {Vujovic, Olga and Yu, Edward and Cherian, Anil and Dar, A. Rashid and Stitt, Larry and Perera, Francisco},
abstractNote = {Purpose: This retrospective review was conducted to determine if delay in the start of radiotherapy after conservative breast surgery had any detrimental effect on local recurrence or disease-free survival in node-negative breast cancer patients. Methods and Materials: A total of 568 patients with T1 and T2, N0 breast cancer were treated with breast-conserving surgery and breast irradiation, without adjuvant systemic therapy, between January 1, 1985 and December 31, 1992 at the London Regional Cancer Centre. The time intervals from definitive breast surgery to breast irradiation used for analysis were 0 to 8 weeks (201 patients), greater than 8 to 12 weeks (235 patients), greater than 12 to 16 weeks (91 patients), and greater than 16 weeks (41 patients). Kaplan-Meier estimates of time to local-recurrence and disease-free survival rates were calculated. Results: Median follow-up was 11.2 years. Patients in all 4 time intervals were similar in terms of age and pathologic features. No statistically significant difference was seen between the 4 groups in local recurrence or disease-free survival with surgery radiotherapy interval (p = 0.521 and p = 0.222, respectively). The overall local-recurrence rate at 5 and 10 years was 4.6% and 11.3%, respectively. The overall disease-free survival at 5 and 10 years was 79.6% and 67.0%, respectively. Conclusion: This retrospective study suggests that delay in the start of breast irradiation of up to 16 weeks from definitive surgery does not increase the risk of recurrence in node-negative breast cancer patients. The certainty of these results is limited by the retrospective nature of this analysis.},
doi = {10.1016/J.IJROBP.2005.0},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 3,
volume = 64,
place = {United States},
year = {Wed Mar 01 00:00:00 EST 2006},
month = {Wed Mar 01 00:00:00 EST 2006}
}