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Title: Optimization of dose distribution for HDR brachytherapy of the prostate using Attraction-Repulsion Model

Abstract

Purpose: To optimize dose distribution for high-dose-rate brachytherapy for prostate cancer, we have developed a new algorithm named Attraction-Repulsion Model (ARM). In this study, we compared the ARM with geometric optimization (GO). Methods and Materials: The ARM was used to optimize the dose distribution by finding the best dwell time combination. ARM requires grids inside the clinical target volume (CTV) and critical organs. These grids generate attraction or repulsion based on specific dose constraints. After calculations were performed repeatedly until the attraction and repulsion forces reached equilibrium, the optimal dwell time distribution was established. We compared the ARM with GO for 10 patients using dose-volume histograms. Results: The CTV ranged from 23 to 48 cc, and the CTV V150 ranged from 52% to 79%, and 23% to 44% for GO and ARM, respectively. This indicates that the dose homogeneity indices, as well as the conformal indices, were higher for ARM than for GO. The urethra V150 was 0-99% and 0-1% for GO and ARM, respectively. Conclusion: The ARM proved to be superior to GO in minimizing the dose to normal structures and in improving dose homogeneity for the target while reducing the dose to normal tissues.

Authors:
 [1];  [1];  [1];  [1];  [2];  [2];  [2]
  1. Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka (Japan)
  2. Department of Radiation Oncology, University of California San Francisco, San Francisco, CA (United States)
Publication Date:
OSTI Identifier:
20793327
Resource Type:
Journal Article
Journal Name:
International Journal of Radiation Oncology, Biology and Physics
Additional Journal Information:
Journal Volume: 64; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2005.09.008; PII: S0360-3016(05)02599-X; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); Journal ID: ISSN 0360-3016
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ALGORITHMS; BRACHYTHERAPY; CARCINOMAS; CRITICAL ORGANS; DOSE RATES; OPTIMIZATION; PATIENTS; PROSTATE; RADIATION DOSE DISTRIBUTIONS; RADIATION DOSES; URINARY TRACT

Citation Formats

Sumida, Iori, Shiomi, Hiroya, Yoshioka, Yasuo, Inoue, Takehiro, Lessard, Etienne, Hsu, I -C.J., and Pouliot, Jean. Optimization of dose distribution for HDR brachytherapy of the prostate using Attraction-Repulsion Model. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.0.
Sumida, Iori, Shiomi, Hiroya, Yoshioka, Yasuo, Inoue, Takehiro, Lessard, Etienne, Hsu, I -C.J., & Pouliot, Jean. Optimization of dose distribution for HDR brachytherapy of the prostate using Attraction-Repulsion Model. United States. https://doi.org/10.1016/J.IJROBP.2005.0
Sumida, Iori, Shiomi, Hiroya, Yoshioka, Yasuo, Inoue, Takehiro, Lessard, Etienne, Hsu, I -C.J., and Pouliot, Jean. 2006. "Optimization of dose distribution for HDR brachytherapy of the prostate using Attraction-Repulsion Model". United States. https://doi.org/10.1016/J.IJROBP.2005.0.
@article{osti_20793327,
title = {Optimization of dose distribution for HDR brachytherapy of the prostate using Attraction-Repulsion Model},
author = {Sumida, Iori and Shiomi, Hiroya and Yoshioka, Yasuo and Inoue, Takehiro and Lessard, Etienne and Hsu, I -C.J. and Pouliot, Jean},
abstractNote = {Purpose: To optimize dose distribution for high-dose-rate brachytherapy for prostate cancer, we have developed a new algorithm named Attraction-Repulsion Model (ARM). In this study, we compared the ARM with geometric optimization (GO). Methods and Materials: The ARM was used to optimize the dose distribution by finding the best dwell time combination. ARM requires grids inside the clinical target volume (CTV) and critical organs. These grids generate attraction or repulsion based on specific dose constraints. After calculations were performed repeatedly until the attraction and repulsion forces reached equilibrium, the optimal dwell time distribution was established. We compared the ARM with GO for 10 patients using dose-volume histograms. Results: The CTV ranged from 23 to 48 cc, and the CTV V150 ranged from 52% to 79%, and 23% to 44% for GO and ARM, respectively. This indicates that the dose homogeneity indices, as well as the conformal indices, were higher for ARM than for GO. The urethra V150 was 0-99% and 0-1% for GO and ARM, respectively. Conclusion: The ARM proved to be superior to GO in minimizing the dose to normal structures and in improving dose homogeneity for the target while reducing the dose to normal tissues.},
doi = {10.1016/J.IJROBP.2005.0},
url = {https://www.osti.gov/biblio/20793327}, journal = {International Journal of Radiation Oncology, Biology and Physics},
issn = {0360-3016},
number = 2,
volume = 64,
place = {United States},
year = {Wed Feb 01 00:00:00 EST 2006},
month = {Wed Feb 01 00:00:00 EST 2006}
}