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Title: Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy

Abstract

Purpose: Heavy-atom-enhanced synchrotron stereotactic radiotherapy (SSR) is a treatment that involves selective accumulation of high-Z elements in tumors followed by stereotactic irradiation with X-rays from a synchrotron source. The purpose of this study was to determine whether the efficacy of iodine-enhanced SSR could be further improved in the F98 rodent glioma model, by using a concomitant injection of an iodinated contrast agent and a transient blood-brain barrier opener (mannitol) during irradiation. Methods and Materials: Fourteen days after intracerebral inoculations of F98 cells, the rats were irradiated with 50-keV X-rays while receiving an infusion of hyperosmotic mannitol with iodine, either intravenously or via the carotid (9 to 15 rats per group, 117 rats total). Results: For doses {<=}15 Gy, the intracarotid infusion of mannitol and iodine improved the rats' survival compared with intravenous injection or irradiation alone. The percentage-increased life spans (ILS) were 91%, 116%, and 169% without iodine, after infusion of iodine and mannitol intravenously, and intracarotid, respectively (15 Gy). At 25 Gy, the rats irradiated without iodine had the longest survival (ILS = 607%), but no additional benefit was obtained with iodine and mannitol. Conclusions: Iodine-enhanced SSR is significantly improved with concomitant intracarotid infusion of iodine and mannitol formore » radiation doses {<=}15 Gy.« less

Authors:
 [1];  [2];  [2];  [1];  [2];  [2];  [1];  [2];  [2];  [1];  [2];  [2];  [3];  [1];  [2];  [2];  [1];  [2];  [2];  [1] more »;  [2];  [2];  [2];  [4] « less
  1. INSERM U647, Grenoble (France)
  2. (France)
  3. Centre Hospitalier Bellevue, Departement de pathologie, Saint Etienne (France)
  4. INSERM U647, Grenoble (France) and Universite Joseph Fourier, Grenoble (France) and European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble (France). E-mail: h.elleaume@esrf.fr
Publication Date:
OSTI Identifier:
20793322
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 64; Journal Issue: 2; Other Information: DOI: 10.1016/j.ijrobp.2005.09.004; PII: S0360-3016(05)02595-2; Copyright (c) 2006 Elsevier Science B.V., Amsterdam, Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD-BRAIN BARRIER; BRAIN; CONTRAST MEDIA; GLIOMAS; INFUSION; INTRAVENOUS INJECTION; IODINE; IRRADIATION; LIFE SPAN; RADIATION DOSES; RADIOTHERAPY; RATS; SYNCHROTRON RADIATION; SYNCHROTRON RADIATION SOURCES; SYNCHROTRONS; X RADIATION

Citation Formats

Adam, Jean-Francois, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, Joubert, Aurelie, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, Biston, Marie-Claude, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, Charvet, Anne-Marie, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, Peoc'h, Michel, Le Bas, Jean-Francois, Universite Joseph Fourier, Grenoble, CHRU Grenoble, Hopital Michallon, Unite IRM, Grenoble, Balosso, Jacques, Universite Joseph Fourier, Grenoble, CHRU Grenoble, Hopital Michallon, Departement de Cancerologie et d'Hematologie, Grenoble, Esteve, Francois, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, CHRU Grenoble, Hopital Michallon, Unite IRM, Grenoble, and Elleaume, Helene. Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy. United States: N. p., 2006. Web. doi:10.1016/J.IJROBP.2005.0.
Adam, Jean-Francois, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, Joubert, Aurelie, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, Biston, Marie-Claude, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, Charvet, Anne-Marie, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, Peoc'h, Michel, Le Bas, Jean-Francois, Universite Joseph Fourier, Grenoble, CHRU Grenoble, Hopital Michallon, Unite IRM, Grenoble, Balosso, Jacques, Universite Joseph Fourier, Grenoble, CHRU Grenoble, Hopital Michallon, Departement de Cancerologie et d'Hematologie, Grenoble, Esteve, Francois, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, CHRU Grenoble, Hopital Michallon, Unite IRM, Grenoble, & Elleaume, Helene. Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy. United States. doi:10.1016/J.IJROBP.2005.0.
Adam, Jean-Francois, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, Joubert, Aurelie, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, Biston, Marie-Claude, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, Charvet, Anne-Marie, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, Peoc'h, Michel, Le Bas, Jean-Francois, Universite Joseph Fourier, Grenoble, CHRU Grenoble, Hopital Michallon, Unite IRM, Grenoble, Balosso, Jacques, Universite Joseph Fourier, Grenoble, CHRU Grenoble, Hopital Michallon, Departement de Cancerologie et d'Hematologie, Grenoble, Esteve, Francois, Universite Joseph Fourier, Grenoble, European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble, CHRU Grenoble, Hopital Michallon, Unite IRM, Grenoble, and Elleaume, Helene. Wed . "Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy". United States. doi:10.1016/J.IJROBP.2005.0.
@article{osti_20793322,
title = {Prolonged survival of Fischer rats bearing F98 glioma after iodine-enhanced synchrotron stereotactic radiotherapy},
author = {Adam, Jean-Francois and Universite Joseph Fourier, Grenoble and European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble and Joubert, Aurelie and Universite Joseph Fourier, Grenoble and European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble and Biston, Marie-Claude and Universite Joseph Fourier, Grenoble and European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble and Charvet, Anne-Marie and Universite Joseph Fourier, Grenoble and European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble and Peoc'h, Michel and Le Bas, Jean-Francois and Universite Joseph Fourier, Grenoble and CHRU Grenoble, Hopital Michallon, Unite IRM, Grenoble and Balosso, Jacques and Universite Joseph Fourier, Grenoble and CHRU Grenoble, Hopital Michallon, Departement de Cancerologie et d'Hematologie, Grenoble and Esteve, Francois and Universite Joseph Fourier, Grenoble and European Synchrotron Radiation Facility, Medical Beamline ID17, Grenoble and CHRU Grenoble, Hopital Michallon, Unite IRM, Grenoble and Elleaume, Helene},
abstractNote = {Purpose: Heavy-atom-enhanced synchrotron stereotactic radiotherapy (SSR) is a treatment that involves selective accumulation of high-Z elements in tumors followed by stereotactic irradiation with X-rays from a synchrotron source. The purpose of this study was to determine whether the efficacy of iodine-enhanced SSR could be further improved in the F98 rodent glioma model, by using a concomitant injection of an iodinated contrast agent and a transient blood-brain barrier opener (mannitol) during irradiation. Methods and Materials: Fourteen days after intracerebral inoculations of F98 cells, the rats were irradiated with 50-keV X-rays while receiving an infusion of hyperosmotic mannitol with iodine, either intravenously or via the carotid (9 to 15 rats per group, 117 rats total). Results: For doses {<=}15 Gy, the intracarotid infusion of mannitol and iodine improved the rats' survival compared with intravenous injection or irradiation alone. The percentage-increased life spans (ILS) were 91%, 116%, and 169% without iodine, after infusion of iodine and mannitol intravenously, and intracarotid, respectively (15 Gy). At 25 Gy, the rats irradiated without iodine had the longest survival (ILS = 607%), but no additional benefit was obtained with iodine and mannitol. Conclusions: Iodine-enhanced SSR is significantly improved with concomitant intracarotid infusion of iodine and mannitol for radiation doses {<=}15 Gy.},
doi = {10.1016/J.IJROBP.2005.0},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 2,
volume = 64,
place = {United States},
year = {Wed Feb 01 00:00:00 EST 2006},
month = {Wed Feb 01 00:00:00 EST 2006}
}