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Title: Electrochemistry of heme-thiolate proteins

Abstract

Heme-thiolate proteins (HTPs) play critical biological roles by catalyzing challenging chemical reactions. The ability of HTPs to selectively oxidize inert substrates under mild conditions has led to much research aimed at the development of useful in vitro oxidation technology. Very complex electron transfer machinery is required to support HTP chemistry, and electrochemical methods provide many of the needed components. The challenge is to find a system that has good electrode-enzyme electronic coupling that, in turn, would drive catalytic turnover at relatively high rates. Several systems reviewed herein have shown promise in experimental work on components that could be part of a molecular machine for the selective oxidation of organic substrates.

Authors:
 [1];  [2]
  1. Department of Chemistry, Occidental College, Los Angeles, CA 90041 (United States)
  2. Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125 (United States). E-mail: hbgray@caltech.edu
Publication Date:
OSTI Identifier:
20793207
Resource Type:
Journal Article
Resource Relation:
Journal Name: Biochemical and Biophysical Research Communications; Journal Volume: 338; Journal Issue: 1; Other Information: DOI: 10.1016/j.bbrc.2005.08.087; PII: S0006-291X(05)01793-6; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; COUPLING; ELECTROCHEMISTRY; ELECTRODES; ELECTRON TRANSFER; ENZYMES; HEME; IN VITRO; OXIDATION; SUBSTRATES

Citation Formats

Udit, Andrew K., and Gray, Harry B.. Electrochemistry of heme-thiolate proteins. United States: N. p., 2005. Web. doi:10.1016/J.BBRC.2005.0.
Udit, Andrew K., & Gray, Harry B.. Electrochemistry of heme-thiolate proteins. United States. doi:10.1016/J.BBRC.2005.0.
Udit, Andrew K., and Gray, Harry B.. Fri . "Electrochemistry of heme-thiolate proteins". United States. doi:10.1016/J.BBRC.2005.0.
@article{osti_20793207,
title = {Electrochemistry of heme-thiolate proteins},
author = {Udit, Andrew K. and Gray, Harry B.},
abstractNote = {Heme-thiolate proteins (HTPs) play critical biological roles by catalyzing challenging chemical reactions. The ability of HTPs to selectively oxidize inert substrates under mild conditions has led to much research aimed at the development of useful in vitro oxidation technology. Very complex electron transfer machinery is required to support HTP chemistry, and electrochemical methods provide many of the needed components. The challenge is to find a system that has good electrode-enzyme electronic coupling that, in turn, would drive catalytic turnover at relatively high rates. Several systems reviewed herein have shown promise in experimental work on components that could be part of a molecular machine for the selective oxidation of organic substrates.},
doi = {10.1016/J.BBRC.2005.0},
journal = {Biochemical and Biophysical Research Communications},
number = 1,
volume = 338,
place = {United States},
year = {Fri Dec 09 00:00:00 EST 2005},
month = {Fri Dec 09 00:00:00 EST 2005}
}