skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Radioprotective effect of amifostine on parotid gland functioning is region dependent

Abstract

Purpose: To investigation the protective ability of amifostine during partial irradiation of the rat parotid gland. Methods and Materials: Single-dose X-ray irradiation was performed by use of collimators with conformal radiation portals for either the 100% volume (15 Gy) or the 50% cranial/caudal partial parotid gland volumes (30 Gy). Amifostine was administered intraperitoneally at a dose of 250 mg per kg body weight, 25 minutes before irradiation. Saliva flow rates, gland weights, and the tissues of the individual lobes were investigated up to 1 year after treatment. Results: A clear protective effect of amifostine was found against loss of saliva flow, the altered appearance of gross morphology, loss of gland weight, and histopathologic changes for the 100% volume gland irradiations and for the 50% volume cranial irradiations but not for the 50% volume caudal irradiations. Conclusions: The protective ability of amifostine is strongly dependent on the irradiated glandular region and observed for later damage only. The major effect of the drug seems to be the prevention of volume effects caused by secondary damage that occurs in shielded parts of the gland. The results of the present study show that understanding of the anatomy and physiology of organs that are tomore » be spared is necessary to ensure optimal preservation of function.« less

Authors:
 [1];  [2];  [3];  [2];  [4]
  1. Department of Radiation and Stress Cell Biology, University Medical Center Groningen and University of Groningen, Groningen (Netherlands). E-mail: a.w.t.konings@med.umcg.nl
  2. Department of Radiation and Stress Cell Biology, University Medical Center Groningen and University of Groningen, Groningen (Netherlands)
  3. Department of Oral and Maxillofacial Surgery, University Medical Center Groningen and University of Groningen, Groningen (Netherlands)
  4. (Netherlands)
Publication Date:
OSTI Identifier:
20788257
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 63; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2005.08.018; PII: S0360-3016(05)02385-0; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; ANATOMY; CARCINOMAS; COLLIMATORS; DAMAGE; DRUGS; GLANDS; HEAD; IRRADIATION; MORPHOLOGY; NECK; PHYSIOLOGY; RADIATION PROTECTION; RADIOPROTECTIVE SUBSTANCES; RATS; SALIVA

Citation Formats

Konings, Antonius W.T., Faber, Hette, Vissink, Arjan, Coppes, Rob P., and Department of Radiation Oncology, University Medical Center Groningen and University of Groningen, Groningen. Radioprotective effect of amifostine on parotid gland functioning is region dependent. United States: N. p., 2005. Web. doi:10.1016/J.IJROBP.2005.0.
Konings, Antonius W.T., Faber, Hette, Vissink, Arjan, Coppes, Rob P., & Department of Radiation Oncology, University Medical Center Groningen and University of Groningen, Groningen. Radioprotective effect of amifostine on parotid gland functioning is region dependent. United States. doi:10.1016/J.IJROBP.2005.0.
Konings, Antonius W.T., Faber, Hette, Vissink, Arjan, Coppes, Rob P., and Department of Radiation Oncology, University Medical Center Groningen and University of Groningen, Groningen. Thu . "Radioprotective effect of amifostine on parotid gland functioning is region dependent". United States. doi:10.1016/J.IJROBP.2005.0.
@article{osti_20788257,
title = {Radioprotective effect of amifostine on parotid gland functioning is region dependent},
author = {Konings, Antonius W.T. and Faber, Hette and Vissink, Arjan and Coppes, Rob P. and Department of Radiation Oncology, University Medical Center Groningen and University of Groningen, Groningen},
abstractNote = {Purpose: To investigation the protective ability of amifostine during partial irradiation of the rat parotid gland. Methods and Materials: Single-dose X-ray irradiation was performed by use of collimators with conformal radiation portals for either the 100% volume (15 Gy) or the 50% cranial/caudal partial parotid gland volumes (30 Gy). Amifostine was administered intraperitoneally at a dose of 250 mg per kg body weight, 25 minutes before irradiation. Saliva flow rates, gland weights, and the tissues of the individual lobes were investigated up to 1 year after treatment. Results: A clear protective effect of amifostine was found against loss of saliva flow, the altered appearance of gross morphology, loss of gland weight, and histopathologic changes for the 100% volume gland irradiations and for the 50% volume cranial irradiations but not for the 50% volume caudal irradiations. Conclusions: The protective ability of amifostine is strongly dependent on the irradiated glandular region and observed for later damage only. The major effect of the drug seems to be the prevention of volume effects caused by secondary damage that occurs in shielded parts of the gland. The results of the present study show that understanding of the anatomy and physiology of organs that are to be spared is necessary to ensure optimal preservation of function.},
doi = {10.1016/J.IJROBP.2005.0},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 63,
place = {United States},
year = {Thu Dec 01 00:00:00 EST 2005},
month = {Thu Dec 01 00:00:00 EST 2005}
}