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Title: The time frame of Epstein-Barr virus latent membrane protein-1 gene to disappear in nasopharyngeal swabs after initiation of primary radiotherapy is an independently significant prognostic factor predicting local control for patients with nasopharyngeal carcinoma

Abstract

Purpose: The presence of Epstein-Barr virus latent membrane protein-1 (LMP-1) gene in nasopharyngeal swabs indicates the presence of nasopharyngeal carcinoma (NPC) mucosal tumor cells. This study was undertaken to investigate whether the time taken for LMP-1 to disappear after initiation of primary radiotherapy (RT) was inversely associated with NPC local control. Methods and Materials: During July 1999 and October 2002, there were 127 nondisseminated NPC patients receiving serial examinations of nasopharyngeal swabbing with detection of LMP-1 during the RT course. The time for LMP-1 regression was defined as the number of days after initiation of RT for LMP-1 results to turn negative. The primary outcome was local control, which was represented by freedom from local recurrence. Results: The time for LMP-1 regression showed a statistically significant influence on NPC local control both univariately (p < 0.0001) and multivariately (p = 0.004). In multivariate analysis, the administration of chemotherapy conferred a significantly more favorable local control (p = 0.03). Advanced T status ({>=} T2b), overall treatment time of external photon radiotherapy longer than 55 days, and older age showed trends toward being poor prognosticators. The time for LMP-1 regression was very heterogeneous. According to the quartiles of the time for LMP-1more » regression, we defined the pattern of LMP-1 regression as late regression if it required 40 days or more. Kaplan-Meier plots indicated that the patients with late regression had a significantly worse local control than those with intermediate or early regression (p 0.0129). Conclusion: Among the potential prognostic factors examined in this study, the time for LMP-1 regression was the most independently significant factor that was inversely associated with NPC local control.« less

Authors:
 [1];  [2];  [3];  [4];  [5];  [2];  [1];  [1];  [1];  [2];  [6]
  1. Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou, Taiwan (China)
  2. Department of Otolaryngology, Chang Gung Memorial Hospital, Linkou, Taiwan (China)
  3. (China)
  4. Department of Family Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan (China)
  5. Department of Anatomic Pathology, Chang Gung Memorial Hospital, Linkou, Taiwan (China)
  6. Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou, Taiwan (China). E-mail: rt3126@adm.cgmh.org.tw
Publication Date:
OSTI Identifier:
20788224
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 63; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2005.05.051; PII: S0360-3016(05)00963-6; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; CHEMOTHERAPY; CONTROL; GENES; MEMBRANE PROTEINS; ONCOGENIC VIRUSES; PATIENTS; RADIOTHERAPY; TUMOR CELLS

Citation Formats

Lin, S.-Y., Chang, K.-P., Graduate Institute of Clinical Medical Sciences, Chang Gung University, Linkou, Taiwan, Hsieh, M.-S., Ueng, S.-H., Hao, S.-P., Tseng, C.-K., Pai, P.-C., Chang, F.-T., Tsai, M.-H., and Tsang, N.-M. The time frame of Epstein-Barr virus latent membrane protein-1 gene to disappear in nasopharyngeal swabs after initiation of primary radiotherapy is an independently significant prognostic factor predicting local control for patients with nasopharyngeal carcinoma. United States: N. p., 2005. Web. doi:10.1016/J.IJROBP.2005.0.
Lin, S.-Y., Chang, K.-P., Graduate Institute of Clinical Medical Sciences, Chang Gung University, Linkou, Taiwan, Hsieh, M.-S., Ueng, S.-H., Hao, S.-P., Tseng, C.-K., Pai, P.-C., Chang, F.-T., Tsai, M.-H., & Tsang, N.-M. The time frame of Epstein-Barr virus latent membrane protein-1 gene to disappear in nasopharyngeal swabs after initiation of primary radiotherapy is an independently significant prognostic factor predicting local control for patients with nasopharyngeal carcinoma. United States. doi:10.1016/J.IJROBP.2005.0.
Lin, S.-Y., Chang, K.-P., Graduate Institute of Clinical Medical Sciences, Chang Gung University, Linkou, Taiwan, Hsieh, M.-S., Ueng, S.-H., Hao, S.-P., Tseng, C.-K., Pai, P.-C., Chang, F.-T., Tsai, M.-H., and Tsang, N.-M. Thu . "The time frame of Epstein-Barr virus latent membrane protein-1 gene to disappear in nasopharyngeal swabs after initiation of primary radiotherapy is an independently significant prognostic factor predicting local control for patients with nasopharyngeal carcinoma". United States. doi:10.1016/J.IJROBP.2005.0.
@article{osti_20788224,
title = {The time frame of Epstein-Barr virus latent membrane protein-1 gene to disappear in nasopharyngeal swabs after initiation of primary radiotherapy is an independently significant prognostic factor predicting local control for patients with nasopharyngeal carcinoma},
author = {Lin, S.-Y. and Chang, K.-P. and Graduate Institute of Clinical Medical Sciences, Chang Gung University, Linkou, Taiwan and Hsieh, M.-S. and Ueng, S.-H. and Hao, S.-P. and Tseng, C.-K. and Pai, P.-C. and Chang, F.-T. and Tsai, M.-H. and Tsang, N.-M.},
abstractNote = {Purpose: The presence of Epstein-Barr virus latent membrane protein-1 (LMP-1) gene in nasopharyngeal swabs indicates the presence of nasopharyngeal carcinoma (NPC) mucosal tumor cells. This study was undertaken to investigate whether the time taken for LMP-1 to disappear after initiation of primary radiotherapy (RT) was inversely associated with NPC local control. Methods and Materials: During July 1999 and October 2002, there were 127 nondisseminated NPC patients receiving serial examinations of nasopharyngeal swabbing with detection of LMP-1 during the RT course. The time for LMP-1 regression was defined as the number of days after initiation of RT for LMP-1 results to turn negative. The primary outcome was local control, which was represented by freedom from local recurrence. Results: The time for LMP-1 regression showed a statistically significant influence on NPC local control both univariately (p < 0.0001) and multivariately (p = 0.004). In multivariate analysis, the administration of chemotherapy conferred a significantly more favorable local control (p = 0.03). Advanced T status ({>=} T2b), overall treatment time of external photon radiotherapy longer than 55 days, and older age showed trends toward being poor prognosticators. The time for LMP-1 regression was very heterogeneous. According to the quartiles of the time for LMP-1 regression, we defined the pattern of LMP-1 regression as late regression if it required 40 days or more. Kaplan-Meier plots indicated that the patients with late regression had a significantly worse local control than those with intermediate or early regression (p 0.0129). Conclusion: Among the potential prognostic factors examined in this study, the time for LMP-1 regression was the most independently significant factor that was inversely associated with NPC local control.},
doi = {10.1016/J.IJROBP.2005.0},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 63,
place = {United States},
year = {Thu Dec 01 00:00:00 EST 2005},
month = {Thu Dec 01 00:00:00 EST 2005}
}