The time frame of Epstein-Barr virus latent membrane protein-1 gene to disappear in nasopharyngeal swabs after initiation of primary radiotherapy is an independently significant prognostic factor predicting local control for patients with nasopharyngeal carcinoma

doi:10.1016/J.IJROBP.2005.0

Title: The time frame of Epstein-Barr virus latent membrane protein-1 gene to disappear in nasopharyngeal swabs after initiation of primary radiotherapy is an independently significant prognostic factor predicting local control for patients with nasopharyngeal carcinoma

Full Record
Other Related Research

Abstract

Purpose: The presence of Epstein-Barr virus latent membrane protein-1 (LMP-1) gene in nasopharyngeal swabs indicates the presence of nasopharyngeal carcinoma (NPC) mucosal tumor cells. This study was undertaken to investigate whether the time taken for LMP-1 to disappear after initiation of primary radiotherapy (RT) was inversely associated with NPC local control. Methods and Materials: During July 1999 and October 2002, there were 127 nondisseminated NPC patients receiving serial examinations of nasopharyngeal swabbing with detection of LMP-1 during the RT course. The time for LMP-1 regression was defined as the number of days after initiation of RT for LMP-1 results to turn negative. The primary outcome was local control, which was represented by freedom from local recurrence. Results: The time for LMP-1 regression showed a statistically significant influence on NPC local control both univariately (p < 0.0001) and multivariately (p = 0.004). In multivariate analysis, the administration of chemotherapy conferred a significantly more favorable local control (p = 0.03). Advanced T status ({>=} T2b), overall treatment time of external photon radiotherapy longer than 55 days, and older age showed trends toward being poor prognosticators. The time for LMP-1 regression was very heterogeneous. According to the quartiles of the time for LMP-1more »« less

Authors:

Lin, S.-Y. ^[1]; Chang, K.-P. ^[2]; Graduate Institute of Clinical Medical Sciences, Chang Gung University, Linkou, Taiwan ^[3]; Hsieh, M.-S. ^[4]; Ueng, S.-H. ^[5]; Hao, S.-P. ^[2]; Tseng, C.-K. ^[1]; Pai, P.-C. ^[1]; Chang, F.-T. ^[1]; Tsai, M.-H. ^[2]; Tsang, N.-M. ^[6]

Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou, Taiwan (China)
Department of Otolaryngology, Chang Gung Memorial Hospital, Linkou, Taiwan (China)
(China)
Department of Family Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan (China)
Department of Anatomic Pathology, Chang Gung Memorial Hospital, Linkou, Taiwan (China)
Department of Radiation Oncology, Chang Gung Memorial Hospital, Linkou, Taiwan (China). E-mail: rt3126@adm.cgmh.org.tw

Publication Date:: Thu Dec 01 00:00:00 EST 2005

OSTI Identifier:: 20788224

Resource Type:: Journal Article

Resource Relation:: Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 63; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2005.05.051; PII: S0360-3016(05)00963-6; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; CHEMOTHERAPY; CONTROL; GENES; MEMBRANE PROTEINS; ONCOGENIC VIRUSES; PATIENTS; RADIOTHERAPY; TUMOR CELLS

Citation Formats


                    Lin, S.-Y., Chang, K.-P., Graduate Institute of Clinical Medical Sciences, Chang Gung University, Linkou, Taiwan, Hsieh, M.-S., Ueng, S.-H., Hao, S.-P., Tseng, C.-K., Pai, P.-C., Chang, F.-T., Tsai, M.-H., and Tsang, N.-M. The time frame of Epstein-Barr virus latent membrane protein-1 gene to disappear in nasopharyngeal swabs after initiation of primary radiotherapy is an independently significant prognostic factor predicting local control for patients with nasopharyngeal carcinoma.  United States: N. p., 2005. 
        Web.  doi:10.1016/J.IJROBP.2005.0.

Copy to clipboard


                    Lin, S.-Y., Chang, K.-P., Graduate Institute of Clinical Medical Sciences, Chang Gung University, Linkou, Taiwan, Hsieh, M.-S., Ueng, S.-H., Hao, S.-P., Tseng, C.-K., Pai, P.-C., Chang, F.-T., Tsai, M.-H., & Tsang, N.-M. The time frame of Epstein-Barr virus latent membrane protein-1 gene to disappear in nasopharyngeal swabs after initiation of primary radiotherapy is an independently significant prognostic factor predicting local control for patients with nasopharyngeal carcinoma.  United States.  doi:10.1016/J.IJROBP.2005.0.

Copy to clipboard


                    Lin, S.-Y., Chang, K.-P., Graduate Institute of Clinical Medical Sciences, Chang Gung University, Linkou, Taiwan, Hsieh, M.-S., Ueng, S.-H., Hao, S.-P., Tseng, C.-K., Pai, P.-C., Chang, F.-T., Tsai, M.-H., and Tsang, N.-M. Thu .  
        "The time frame of Epstein-Barr virus latent membrane protein-1 gene to disappear in nasopharyngeal swabs after initiation of primary radiotherapy is an independently significant prognostic factor predicting local control for patients with nasopharyngeal carcinoma".  United States.  
        doi:10.1016/J.IJROBP.2005.0.

Copy to clipboard


                    
@article{osti_20788224,

  title        = {The time frame of Epstein-Barr virus latent membrane protein-1 gene to disappear in nasopharyngeal swabs after initiation of primary radiotherapy is an independently significant prognostic factor predicting local control for patients with nasopharyngeal carcinoma},

  author       = {Lin, S.-Y. and Chang, K.-P. and Graduate Institute of Clinical Medical Sciences, Chang Gung University, Linkou, Taiwan and Hsieh, M.-S. and Ueng, S.-H. and Hao, S.-P. and Tseng, C.-K. and Pai, P.-C. and Chang, F.-T. and Tsai, M.-H. and Tsang, N.-M.},

  abstractNote = {Purpose: The presence of Epstein-Barr virus latent membrane protein-1 (LMP-1) gene in nasopharyngeal swabs indicates the presence of nasopharyngeal carcinoma (NPC) mucosal tumor cells. This study was undertaken to investigate whether the time taken for LMP-1 to disappear after initiation of primary radiotherapy (RT) was inversely associated with NPC local control. Methods and Materials: During July 1999 and October 2002, there were 127 nondisseminated NPC patients receiving serial examinations of nasopharyngeal swabbing with detection of LMP-1 during the RT course. The time for LMP-1 regression was defined as the number of days after initiation of RT for LMP-1 results to turn negative. The primary outcome was local control, which was represented by freedom from local recurrence. Results: The time for LMP-1 regression showed a statistically significant influence on NPC local control both univariately (p < 0.0001) and multivariately (p = 0.004). In multivariate analysis, the administration of chemotherapy conferred a significantly more favorable local control (p = 0.03). Advanced T status ({>=} T2b), overall treatment time of external photon radiotherapy longer than 55 days, and older age showed trends toward being poor prognosticators. The time for LMP-1 regression was very heterogeneous. According to the quartiles of the time for LMP-1 regression, we defined the pattern of LMP-1 regression as late regression if it required 40 days or more. Kaplan-Meier plots indicated that the patients with late regression had a significantly worse local control than those with intermediate or early regression (p 0.0129). Conclusion: Among the potential prognostic factors examined in this study, the time for LMP-1 regression was the most independently significant factor that was inversely associated with NPC local control.},

  doi          = {10.1016/J.IJROBP.2005.0},

  journal      = {International Journal of Radiation Oncology, Biology and Physics},

  number       = 5,

  volume       = 63,

  place        = {United States},

  year         = {Thu Dec 01 00:00:00 EST 2005},

  month        = {Thu Dec 01 00:00:00 EST 2005}

}

Copy to clipboard

Journal Article:

DOI: 10.1016/J.IJROBP.2005.0

Other availability

Find in Google Scholar

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

Long-Term Prognostic Effects of Plasma Epstein-Barr Virus DNA by Minor Groove Binder-Probe Real-Time Quantitative PCR on Nasopharyngeal Carcinoma Patients Receiving Concurrent Chemoradiotherapy

Journal Article Lin, J.-C. ; Wang, W.-Y. ; Liang, W.-M. ; ... - International Journal of Radiation Oncology, Biology and Physics

Purpose: To evaluate the long-term prognostic impact of plasma Epstein-Barr virus (EBV) DNA concentration measured by real-time quantitative polymerase chain reaction (RTQ-PCR) in nasopharyngeal carcinoma (NPC) patients receiving concurrent chemoradiotherapy (CCRT). Methods and Materials: Epstein-Barr virus DNA was retrospectively measured from stock plasma of 152 biopsy-proven NPC patients with Stage II-IV (M0) disease with a RTQ-PCR using the minor groove binder-probe. All patients received CCRT with a median follow-up of 78 months. We divided patients into three subgroups: (1) low pretreatment EBV DNA (<1,500 copies/mL) and undetectable posttreatment EBV DNA (pre-L/post-U) (2) high pretreatment EBV DNA ({>=}1,500 copies/mL) and undetectablemore »« less
DOI: 10.1016/j.ijrobp.2007.02.012
Demonstration of the serum antibody to Epstein-Barr virus specific DNA polymerased (EBV-DP) from patients with nasopharyngeal carcinoma (NPC)

Conference Tan, R.S. ; Li, J.S. ; Grill, S. ; ... - Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

Raji cells, an EBV genome carrying and nonproducer cell line, treated with tetradecanoyl-phorbol-13-acetate (TPA) and n-butyrate could induce a special DNA polymerase which has properties that are similar to the EBV-DP induced by TPA in P/sub 3/HR-I cells, an EBV producer cell line. Since EBV was found to have a strong association with NPC, and antibodies against EBV proteins or enzymes were found in high levels in sera from these patients, the possible presence of serum antibody against EBV-DP was examined. The serum titer of antibody to EBV-DP was found to have 190 +/- 84 units/ml serum (mean +/- S.D.)more »« less
Metronomic Adjuvant Chemotherapy Improves Treatment Outcome in Nasopharyngeal Carcinoma Patients With Postradiation Persistently Detectable Plasma Epstein-Barr Virus Deoxyribonucleic Acid

Journal Article Twu, Chih-Wen ; Department of Otorhinolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan ; Wang, Wen-Yi ; ... - International Journal of Radiation Oncology, Biology and Physics

Purpose: To investigate the effects of adjuvant chemotherapy in nasopharyngeal carcinoma (NPC) patients with persistently detectable plasma Epstein-Barr virus DNA (pEBV DNA) after curative radiation therapy plus induction/concurrent chemotherapy. Methods and Materials: The study population consisted of 625 NPC patients with available pEBV DNA levels before and after treatment. Eighty-five patients with persistently detectable pEBV DNA after 1 week of completing radiation therapy were eligible for this retrospective study. Of the 85 patients, 33 were administered adjuvant chemotherapy consisting of oral tegafur-uracil (2 capsules twice daily) for 12 months with (n=4) or without (n=29) preceding intravenous chemotherapy of mitomycin-C, epirubicin, and cisplatin.more »« less
DOI: 10.1016/J.IJROBP.2014.01.052
Clinical Utility of Epstein-Barr Virus DNA Testing in the Treatment of Nasopharyngeal Carcinoma Patients

Journal Article Kim, Kelly Y., E-mail: kimke@mail.nih.gov ; Le, Quynh-Thu ; Yom, Sue S. ; ... - International Journal of Radiation Oncology, Biology and Physics

Epstein-Barr virus (EBV) DNA analysis has been shown to be useful for early detection, prognostication, and monitoring of treatment response of nasopharyngeal carcinoma (NPC), and the recent literature provides growing evidence of the clinical utility of EBV DNA testing, particularly to inform treatment decisions for NPC patients. Despite the fact that NPC is a rare disease, the NRG Oncology cooperative group has successfully activated a phase 2/3 randomized clinical trial for NPC with international partners and in that process has discovered that the development of a harmonized EBV DNA test is absolutely critical for integration into clinical trials and for futuremore »« less
DOI: 10.1016/J.IJROBP.2017.03.018
High-Sensitivity C-Reactive Protein Complements Plasma Epstein-Barr Virus Deoxyribonucleic Acid Prognostication in Nasopharyngeal Carcinoma: A Large-Scale Retrospective and Prospective Cohort Study

Journal Article Tang, Lin-Quan ; Department of Nasopharyngeal Carcinoma, Sun Yat-sen University, Guangzhou ; Li, Chao-Feng ; ... - International Journal of Radiation Oncology, Biology and Physics

Purpose: To evaluate the effects of combining the assessment of circulating high-sensitivity C-reactive protein (hs-CRP) with that of Epstein-Barr virus DNA (EBV DNA) in the pretherapy prognostication of nasopharyngeal carcinoma (NPC). Patients and Methods: Three independent cohorts of NPC patients (training set of n=3113, internal validation set of n=1556, and prospective validation set of n=1668) were studied. Determinants of disease-free survival, distant metastasis–free survival, and overall survival were assessed by multivariate analysis. Hazard ratios and survival probabilities of the patient groups, segregated by clinical stage (T1-2N0-1M0, T3-4N0-1M0, T1-2N2-3M0, and T3-4N2-3M0) and EBV DNA load (low or high) alone, and alsomore »« less
DOI: 10.1016/J.IJROBP.2014.10.005

Similar Records