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Title: Tumor vascularity evaluated by transrectal color Doppler US in predicting therapy outcome for low-lying rectal cancer

Abstract

Purpose: To evaluate the impact on T downstaging of the vasculature supplying blood flow to rectal cancer evaluated by color Doppler ultrasound. Methods and Materials: Color Doppler images were graded in 29 T3-staged rectal carcinoma patients sonographically just before chemoradiation. Any arterial vessels detected in rectal masses were assigned one of two grades: vascularity was considered as grade 1 for vessels feeding the periphery and as grade 2 for vessels coursing in all rectal masses within its peripheral and central portions. The pulsatility indices (PI = peak systolic velocity - end-diastolic velocity/time-averaged maximum velocity) were calculated in the central and peripheral portions. Results: The pathologic observations showed a change in stage in 15 of the 23 patients graded 2, positive predictive value 65.2% (p = 0.047), and in one of the six rectal cancers graded 1 (negative predictive value, 83.3%). The minimal peripheral PI values in rectal cancer graded 2 were higher in nonresponding (2.2 {+-} 1.3) than in responding lesions (1.6 {+-} 0.7) p = 0.01. Conclusion: Vascularity graded 2 associated with low peripheral PI values are indicators of therapy outcome. Vascularity graded 1 and high peripheral PI values in graded 2 have negative predictive value.

Authors:
 [1];  [2];  [3];  [2];  [2];  [4];  [2]
  1. Department of Radiology, Universita Cattolica, Policlinico 'Agostino Gemelli', Largo Agostino Gemelli, Rome (Italy). E-mail: a.leonemd@tiscalinet.it
  2. Department of Radiology, Universita Cattolica, Policlinico 'Agostino Gemelli', Largo Agostino Gemelli, Rome (Italy)
  3. Department of Surgery, Universita Cattolica, Policlinico 'Agostino Gemelli', Largo Agostino Gemelli, Rome (Italy)
  4. Department of Pathology, Universita Cattolica, Policlinico 'Agostino Gemelli', Largo Agostino Gemelli, Rome (Italy)
Publication Date:
OSTI Identifier:
20788219
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; Journal Volume: 63; Journal Issue: 5; Other Information: DOI: 10.1016/j.ijrobp.2005.04.050; PII: S0360-3016(05)00826-6; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA)
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD FLOW; CARCINOMAS; IMAGES; PATIENTS; RADIOLOGY; RADIOTHERAPY; RECTUM

Citation Formats

Barbaro, Brunella, Valentini, Vincenzo, Coco, Claudio, Mancini, Anna Paola, Gambacorta, Maria Antonietta, Vecchio, Fabio Maria, and Bonomo, Lorenzo. Tumor vascularity evaluated by transrectal color Doppler US in predicting therapy outcome for low-lying rectal cancer. United States: N. p., 2005. Web. doi:10.1016/J.IJROBP.2005.0.
Barbaro, Brunella, Valentini, Vincenzo, Coco, Claudio, Mancini, Anna Paola, Gambacorta, Maria Antonietta, Vecchio, Fabio Maria, & Bonomo, Lorenzo. Tumor vascularity evaluated by transrectal color Doppler US in predicting therapy outcome for low-lying rectal cancer. United States. doi:10.1016/J.IJROBP.2005.0.
Barbaro, Brunella, Valentini, Vincenzo, Coco, Claudio, Mancini, Anna Paola, Gambacorta, Maria Antonietta, Vecchio, Fabio Maria, and Bonomo, Lorenzo. Thu . "Tumor vascularity evaluated by transrectal color Doppler US in predicting therapy outcome for low-lying rectal cancer". United States. doi:10.1016/J.IJROBP.2005.0.
@article{osti_20788219,
title = {Tumor vascularity evaluated by transrectal color Doppler US in predicting therapy outcome for low-lying rectal cancer},
author = {Barbaro, Brunella and Valentini, Vincenzo and Coco, Claudio and Mancini, Anna Paola and Gambacorta, Maria Antonietta and Vecchio, Fabio Maria and Bonomo, Lorenzo},
abstractNote = {Purpose: To evaluate the impact on T downstaging of the vasculature supplying blood flow to rectal cancer evaluated by color Doppler ultrasound. Methods and Materials: Color Doppler images were graded in 29 T3-staged rectal carcinoma patients sonographically just before chemoradiation. Any arterial vessels detected in rectal masses were assigned one of two grades: vascularity was considered as grade 1 for vessels feeding the periphery and as grade 2 for vessels coursing in all rectal masses within its peripheral and central portions. The pulsatility indices (PI = peak systolic velocity - end-diastolic velocity/time-averaged maximum velocity) were calculated in the central and peripheral portions. Results: The pathologic observations showed a change in stage in 15 of the 23 patients graded 2, positive predictive value 65.2% (p = 0.047), and in one of the six rectal cancers graded 1 (negative predictive value, 83.3%). The minimal peripheral PI values in rectal cancer graded 2 were higher in nonresponding (2.2 {+-} 1.3) than in responding lesions (1.6 {+-} 0.7) p = 0.01. Conclusion: Vascularity graded 2 associated with low peripheral PI values are indicators of therapy outcome. Vascularity graded 1 and high peripheral PI values in graded 2 have negative predictive value.},
doi = {10.1016/J.IJROBP.2005.0},
journal = {International Journal of Radiation Oncology, Biology and Physics},
number = 5,
volume = 63,
place = {United States},
year = {Thu Dec 01 00:00:00 EST 2005},
month = {Thu Dec 01 00:00:00 EST 2005}
}